Effect of prolactin antiserum on growth and resorption of tadpole tail.

Rabbit antiserum to bullfrog prolactin(A/S) or normal rabbit serum(NRS) was administrated to premetamorphic bullfrog larvae. Collagen synthesis in the tail fin was not affected by A/S. However, the enhancement of collagen synthesis induced by pimozide treatment was completely blocked by A/S. Premetamorphic tadpoles kept in 3 x 10(-8) M thyroxine received A/S or NRS. A/S accelerated tail resorption. The results indicate that the endogenous prolactin is acting as an antimetamorphic hormone, although it is not certain that normally circulating level of prolactin contributes to promoting the growth of the tail fin in larval bullfrogs.

[1]  S. Kikuyama,et al.  Radioimmunoassay of prolactin in plasma of bullfrog tadpoles. , 1982, Endocrinologia japonica.

[2]  S. Kikuyama,et al.  In vitro studies on the regulation of prolactin secretion in the bullfrog pituitary gland. , 1982, General and comparative endocrinology.

[3]  S. Kikuyama,et al.  Purification and properties of bullfrog prolactin. , 1981, Endocrinologia japonica.

[4]  S. Kikuyama,et al.  Possible involvement of dopamine in the release of prolactin-like hormone from bullfrog pituitary gland. , 1980, General and comparative endocrinology.

[5]  S. Kikuyama,et al.  Growth-promoting and antimetamorphic hormone in pituitary glands of bullfrogs. , 1980, General and comparative endocrinology.

[6]  S. Kikuyama,et al.  INHIBITION OF THYROXINE‐INDUCED RESORPTION OF TADPOLE TAIL BY ADENOSINE 3′, 5′‐CYCLIC MONOPHOSPHATE , 1979, Development, growth & differentiation.

[7]  C. S. Nicoll,et al.  Effects of antisera to bullfrog prolactin and growth hormone on metamorphosis of Rana catesbeiana tadpoles. , 1977, General and comparative endocrinology.

[8]  H. Liang,et al.  The changes of growth activities in pituitaries of tadpoles at different metamorphic stages. , 1976, General and comparative endocrinology.

[9]  K. Yoshizato,et al.  Presence of growth-promoting factor in the frog pituitary gland. , 1972, General and comparative endocrinology.

[10]  K. Yoshizato,et al.  EFFECT OF PROLACTIN ON THE TADPOLE TAIL FIN. II. STIMULATORY EFFECT OF PROLACTIN ON THE SYNTHESIS OF ACID MUCOPOLYSACCHARIDE OF THE TADPOLE TAIL FIN. , 1970, Development, growth & differentiation.

[11]  K. Yoshizato,et al.  EFFECT OF PROLACTIN ON THE TADPOLE TAIL FIN. I. STIMULATORY EFFECT OF PROLACTIN ON THE COLLAGEN SYNTHESIS OF THE TADPOLE TAIL FIN , 1969, Development, growth & differentiation.

[12]  W. Etkin,et al.  Prolactin-like antithyroid action of pituitary grafts in tadpoles , 1969 .

[13]  W. Etkin,et al.  Thyroxine induced tail resorption in vitro as affected by anterior pituitary hormones. , 1968, The Journal of experimental zoology.

[14]  W. Etkin,et al.  Antagonism between prolactin and thyroid hormone in amphibian development. , 1967, The Journal of experimental zoology.

[15]  H. Bern,et al.  GROWTH-PROMOTING EFFECTS OF MAMMALIAN PROLACTIN AND GROWTH HORMONE IN TADPOLES OF RANA CATESBEIANA. , 1964, The Journal of experimental zoology.

[16]  W. Etkin,et al.  Excess growth in tadpoles after transplantation of the adenohypophysis. , 1960, Endocrinology.

[17]  R. D. Harkness,et al.  Extraction of Collagen from Tissues , 1955, Nature.