Developmental Program of Epileptogenesis in the Brain of EL Mice

Summary:  Purpose: We recently observed inducible nitric oxide synthetase (iNOS) expression and decreased Cu, Zn‐superoxide dismutase (Cu, Zn‐SOD) activities in the hippocampus of epileptic mutant EL mice at the age of 30 weeks. In addition, the immediate early gene (IEG) c‐fos is unusually expressed in the interictal period, suggesting activation of protein cascades associated with the epileptogenesis. Furthermore, DNA fragmentation has been detected preferentially in the hippocampus CA1 and the parietal cortex of EL mouse brain. It remains to be seen, however, how these abnormalities are related to the DNA fragmentation, and whether neuronal cell loss is involved. The present study was designed to address these issues.

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