To foster the implementation of Industrial Symbiosis, several support tools have been developed to facilitate the dissemination of Industrial Symbiosis (IS) and the engagement of stakeholders; the establishment of exchanges between companies, the so-called synergies; and the assessment of impacts and benefits. Despite this, it has been found that stakeholders still do not have a clear envisioning of the required steps to the technical implementation of synergies and there are no facilitating tools, such as methodologies, frameworks, modelling tools, and databases, among others, that aid to technically support decision-making of synergy implementation. Thus, the goal of this paper is to present a dedicated framework that provides a set of guidelines and defines a technical viability analysis to support the implementation of potential synergies, which can be used and replicated by any IS practitioner. It comprehends a methodological approach to assess the compliance of a given synergy opportunity; its characterization concerning the definition of the necessary intermediary steps for the technical implementation; and an assessment of the technical feasibility of the synergy. The implementation of the framework allowed the successful technical validation of the studied synergy opportunities, providing a final technical viability assessment that can support decision-making of technology selection and synergy implementation.