Effects of divided attention on temporal processing in patients with lesions of the cerebellum or frontal lobe.

Prefrontal cortex and cerebellum have both been implicated in temporal processing tasks although the exact contribution of each system remains unclear. To investigate this issue, control participants and patients with either prefrontal or cerebellar lesions were tested on temporal and nontemporal perceptual tasks under 2 levels of attentional load. Each trial involved a comparison between a standard tone and a subsequent comparison tone that varied in frequency, duration, or both. When participants had to make concurrent judgments on both dimensions, patients with frontal lobe lesions were significantly impaired on both tasks whereas the variability of cerebellar patients increased in the duration task only. This dissociation suggests that deficits on temporal processing tasks observed in frontal patients can be related to the attention demands of such tasks; cerebellar patients have a more specific problem related to timing.

[1]  R B Ivry,et al.  Dissociable contributions of the prefrontal and neocerebellar cortex to time perception. , 1998, Brain research. Cognitive brain research.

[2]  F. Macar,et al.  Effects of attention manipulation on judgments of duration and of intensity in the visual modality , 1997, Memory & cognition.

[3]  C. Gallistel,et al.  Toward a neurobiology of temporal cognition: advances and challenges , 1997, Current Opinion in Neurobiology.

[4]  R B Ivry,et al.  Preserved performance by cerebellar patients on tests of word generation, discrimination learning, and attention. , 1997, Learning & memory.

[5]  J. Townsend,et al.  Attention coordination and anticipatory control. , 1997, International review of neurobiology.

[6]  Scott W. Brown.  Attentional resources in timing: Interference effects in concurrent temporal and nontemporal working memory tasks , 1997, Perception & psychophysics.

[7]  Jennifer A. Mangels,et al.  Strategic processing and memory for temporal order in patients with frontal lobe lesions. , 1997, Neuropsychology.

[8]  R. Ivry.  The representation of temporal information in perception and motor control , 1996, Current Opinion in Neurobiology.

[9]  F. Macar,et al.  Can the level of prefrontal activity provide an index of performance in humans? , 1996, Neuroscience Letters.

[10]  M. Jüptner,et al.  The human cerebellum and temporal information processing--results from a PET experiment. , 1996, Neuroreport.

[11]  Richard B. Ivry,et al.  Cerebellar involvement in eyeblink classical conditioning in humans. , 1996 .

[12]  S. Grossberg,et al.  Metabotropic Glutamate Receptor Activation in Cerebellar Purkinje Cells as Substrate for Adaptive Timing of the Classically Conditioned Eye-Blink Response , 1996, The Journal of Neuroscience.

[13]  J. Mazziotta,et al.  Brain Activation Induced by Estimation of Duration: A PET Study , 1996, NeuroImage.

[14]  R. B. Ivry,et al.  Reduced Timing Variability in Patients with Unilateral Cerebellar Lesions during Bimanual Movements , 1996, Journal of Cognitive Neuroscience.

[15]  Françoise Macar,et al.  Prefrontal slow potential in temporal compared to nontemporal tasks. , 1996 .

[16]  Ernst Pöppel,et al.  Timing in perceptual and motor tasks after disturbances of the brain , 1996 .

[17]  W. Meck.  Neuropharmacology of timing and time perception. , 1996, Brain research. Cognitive brain research.

[18]  JORDAN GRAFMAN,et al.  Duration Processing after Frontal Lobe Lesions a , 1995, Annals of the New York Academy of Sciences.

[19]  M. Jüptner,et al.  Localization of a cerebellar timing process using PET , 1995, Neurology.

[20]  Mark Nawrot,et al.  Motion perception deficits from midline cerebellar lesions in human , 1995, Vision Research.

[21]  R. Ivry,et al.  Perception and production of temporal intervals across a range of durations: evidence for a common timing mechanism. , 1995, Journal of experimental psychology. Human perception and performance.

[22]  Arthur P. Shimamura,et al.  Memory and frontal lobe function. , 1995 .

[23]  Dean V. Buonomano,et al.  Neural Network Model of the Cerebellum: Temporal Discrimination and the Timing of Motor Responses , 1999, Neural Computation.

[24]  M. Hallett,et al.  Disturbances of kinaesthesia in patients with cerebellar disorders. , 1994, Brain : a journal of neurology.

[25]  F. Macar,et al.  Controlled attention sharing influences time estimation , 1994, Memory & cognition.

[26]  P. Strick,et al.  Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. , 1994, Science.

[27]  J Townsend,et al.  Impairment in shifting attention in autistic and cerebellar patients. , 1994, Behavioral neuroscience.

[28]  Robert T. Knight,et al.  Attention Regulation and Human Prefrontal Cortex , 1994 .

[29]  A. Thierry,et al.  Motor and Cognitive Functions of the Prefrontal Cortex , 1994, Research and Perspectives in Neurosciences.

[30]  N Birbaumer,et al.  Classical conditioning after cerebellar lesions in humans. , 1993, Behavioral neuroscience.

[31]  R Ivry,et al.  Cerebellar Involvement in the Explicit Representation of Temporal Information a , 1993, Annals of the New York Academy of Sciences.

[32]  N. Birbaumer,et al.  The cerebellum and cognitive functions in humans. , 1993, Behavioral neuroscience.

[33]  Curt von Euler,et al.  Temporal Information Processing in the Nervous System: Special Reference to Dyslexia and Dysphasia. Conference proceedings. New York City, New York, September 12-15, 1992. , 1993, Annals of the New York Academy of Sciences.

[34]  M. Mauk,et al.  Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[35]  E. Courchesne,et al.  A new role for the cerebellum in cognitive operations. , 1992, Behavioral neuroscience.

[36]  P. Goldman-Rakic.  Working memory and the mind. , 1992, Scientific American.

[37]  E. Courchesne,et al.  Contribution of the cerebellum to neuropsychological functioning: Evidence from a case of cerebellar degenerative disorder , 1992, Neuropsychologia.

[38]  G. Bruder,et al.  Lateral asymmetries of event-related potential slow waves. , 1992 .

[39]  Gabriel Leonard,et al.  Frontal-lobe contribution to recency judgements , 1991, Neuropsychologia.

[40]  T Elbert,et al.  The processing of temporal intervals reflected by CNV-like brain potentials. , 1991, Psychophysiology.

[41]  R. Ivry,et al.  Impaired Velocity Perception in Patients with Lesions of the Cerebellum , 1991, Journal of Cognitive Neuroscience.

[42]  M. Corbetta,et al.  Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[43]  J. Hore,et al.  Cerebellar dysmetria at the elbow, wrist, and fingers. , 1991, Journal of neurophysiology.

[44]  Arthur P. Shimamura,et al.  Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients , 1990, Neuropsychologia.

[45]  O. W. Henson,et al.  The descending auditory pathway and acousticomotor systems: connections with the inferior colliculus , 1990, Brain Research Reviews.

[46]  R. F. Thompson,et al.  Neural mechanisms of classical conditioning in mammals. , 1990, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[47]  S. Keele,et al.  Timing Functions of The Cerebellum , 1989, Journal of Cognitive Neuroscience.

[48]  A. Benton,et al.  The Multilingual Aphasia Examination: Use with children , 1989 .

[49]  Dan Zakay,et al.  Chapter 10 Subjective Time and Attentional Resource Allocation: An Integrated Model of Time Estimation , 1989 .

[50]  R. Church,et al.  Attention and the frontal cortex as examined by simultaneous temporal processing , 1988, Neuropsychologia.

[51]  R. F. Thompson,et al.  Initial localization of the acoustic conditioned stimulus projection system to the cerebellum essential for classical eyelid conditioning. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Madigan,et al.  Maximum-likelihood psychometric procedures in two-alternative forced-choice: Evaluation and recommendations , 1987, Perception & psychophysics.

[53]  R M Church,et al.  Properties of the Internal Clock a , 1984, Annals of the New York Academy of Sciences.

[54]  R M Church,et al.  Scalar Timing in Memory , 1984, Annals of the New York Academy of Sciences.

[55]  V. Braitenberg,et al.  Some Quantitative Aspects of Cerebellar Anatomy as a Guide to Speculation on Cerebellar Functions , 1984 .

[56]  D. Stuss,et al.  Neuropsychological studies of the frontal lobes. , 1984, Psychological bulletin.

[57]  D. Pandya,et al.  Association areas of the cerebral cortex , 1982, Trends in Neurosciences.

[58]  A Pentland,et al.  Maximum likelihood estimation: The best PEST , 1980, Perception & psychophysics.

[59]  W. Kintsch,et al.  Memory and cognition , 1977 .

[60]  L. Aitkin,et al.  Responses of single units in cerebellar vermis of the cat to monaural and binaural stimuli. , 1975, Journal of neurophysiology.

[61]  M. M. Taylor,et al.  PEST: Efficient Estimates on Probability Functions , 1967 .

[62]  V. Braitenberg.  Is the cerebellar cortex a biological clock in the millisecond range? , 1967, Progress in brain research.

[63]  M. Treisman.  Temporal discrimination and the indifference interval. Implications for a model of the "internal clock". , 1963, Psychological monographs.

[64]  D. A. Grant,et al.  A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem. , 1948, Journal of experimental psychology.