Binding of 15N-labeled isoniazid to KatG and KatG(S315T): Use of two- spin [zz]-order relaxation rate for 15N-fe distance determination

Isoniazid has been used to treat tuberculosis for over 40 years, but its mechanism of action is not yet fully understood. It is known that a catalase/peroxidase KatG is required for isoniazid activ...