The Regulation of Physiological Changes During Mammalian Aging

Much evidence suggests that intrinsic molecular or cellular aging mechanisms need not be invoked to explain most age-related cellular changes and pathological conditions. Analysis of a widely scattered literature indicates that hormones and neural factors regulate a great number of cellular aging phenomena of mammals. It is proposed that age-related changes after maturation result from an extension of the neural and endocrine mechanisms that control earlier development and that produce a regulatory cascade of changing neural, endocrine, and target-tissue interactions.

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