Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis

[1]  D. Abraham,et al.  Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. , 2001, The Journal of clinical investigation.

[2]  S. Sa,et al.  The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts , 2001, Molecular pathology : MP.

[3]  T. Rabelink,et al.  In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[4]  R. Goldschmeding,et al.  Identification of human ccn2 (connective tissue growth factor) promoter polymorphisms , 2001, Molecular pathology : MP.

[5]  T. Nakaki,et al.  Static Pressure Regulates Connective Tissue Growth Factor Expression in Human Mesangial Cells* 210 , 2001, The Journal of Biological Chemistry.

[6]  S. Sa,et al.  CTGF and SMADs, Maintenance of Scleroderma Phenotype Is Independent of SMAD Signaling* , 2001, The Journal of Biological Chemistry.

[7]  B. Perbal.  NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues , 2001, Molecular pathology : MP.

[8]  L. Lau,et al.  The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts* , 2001, The Journal of Biological Chemistry.

[9]  T. Sugimoto,et al.  Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. , 2001, Biochemical and biophysical research communications.

[10]  Gary R. Grotendorst,et al.  Connective Tissue Growth Factor Expression in Pediatric Myofibroblastic Tumors , 2001, Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.

[11]  Gary R. Grotendorst,et al.  CCN proteins are distinct from, and should not be considered members of, the insulin-like growth factor-binding protein superfamily. , 2000, The Journal of clinical endocrinology and metabolism.

[12]  L. Aiello,et al.  Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells* , 2000, The Journal of Biological Chemistry.

[13]  B. Williams,et al.  Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation* , 2000, The Journal of Biological Chemistry.

[14]  S. Kondo,et al.  Characterization of a mouse ctgf 3'-UTR segment that mediates repressive regulation of gene expression. , 2000, Biochemical and biophysical research communications.

[15]  R. Chambers,et al.  Thrombin Is a Potent Inducer of Connective Tissue Growth Factor Production via Proteolytic Activation of Protease-activated Receptor-1* , 2000, The Journal of Biological Chemistry.

[16]  J. Schwab,et al.  Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction , 2000, Neuropathology and applied neurobiology.

[17]  D. Brigstock,et al.  Connective tissue growth factor: what's in a name? , 2000, Molecular genetics and metabolism.

[18]  D. Durant,et al.  Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. , 2000, American journal of physiology. Endocrinology and metabolism.

[19]  D. Pennington,et al.  Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. , 2000, Experimental cell research.

[20]  H. Wex,et al.  CTGF (IGFBP-rP2) is specifically expressed in malignant lymphoblasts of patients with acute lymphoblastic leukaemia (ALL) , 2000, British Journal of Cancer.

[21]  J. Flammer,et al.  Connective Tissue Growth Factor in Retrocorneal Membranes and Corneal Scars , 2000, Ophthalmologica.

[22]  M. Takigawa,et al.  Effects of CTGF/Hcs24, a hypertrophic chondrocyte‐specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro , 2000, Journal of cellular physiology.

[23]  H. Friess,et al.  Connective tissue growth factor in human liver cirrhosis. , 2000, Liver.

[24]  S. Sa,et al.  Tumor Necrosis Factor α Suppresses the Induction of Connective Tissue Growth Factor by Transforming Growth Factor-β in Normal and Scleroderma Fibroblasts* , 2000, The Journal of Biological Chemistry.

[25]  T. Nakaki,et al.  Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells. , 2000, European journal of pharmacology.

[26]  L. Thal,et al.  Blood Levels of Alpha-1-Antichymotrypsin and Risk Factors for Alzheimer’s Disease: Effects of Gender and Apolipoprotein E Genotype , 2000, Dementia and Geriatric Cognitive Disorders.

[27]  Gary R. Grotendorst,et al.  CTGF modulates cell cycle progression in cAMP‐arrested NRK fibroblasts , 2000, Journal of cellular physiology.

[28]  T. Nakanishi,et al.  Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. , 2000, The Journal of rheumatology.

[29]  M. Takigawa,et al.  Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture1. , 2000, Endocrinology.

[30]  J. Yee,et al.  Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. , 2000, Journal of the American Society of Nephrology : JASN.

[31]  T. Lüscher,et al.  Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7* , 1999, The Journal of Biological Chemistry.

[32]  R. Goldstein,et al.  Regulation of connective tissue growth factor expression by prostaglandin E(2). , 1999, The American journal of physiology.

[33]  M. Spiteri,et al.  Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. , 1999, American journal of respiratory cell and molecular biology.

[34]  T. Lüscher,et al.  Overexpression of connective tissue growth factor gene induces apoptosis in human aortic smooth muscle cells. , 1999, Circulation.

[35]  V. Petkov,et al.  A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. , 1999, The New England journal of medicine.

[36]  M. Takigawa,et al.  Role and interaction of connective tissue growth factor with transforming growth factor‐β in persistent fibrosis: A mouse fibrosis model , 1999, Journal of cellular physiology.

[37]  Gary R. Grotendorst,et al.  Connective tissue growth factor mediates transforming growth factor b-induced collagen synthesis : down-regulation by cAMP , 1999 .

[38]  S. Merajver,et al.  A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[39]  L. Lau,et al.  Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin αIIbβ3 * , 1999, The Journal of Biological Chemistry.

[40]  T. Matsumura,et al.  Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. , 1999, Journal of biochemistry.

[41]  M. Takigawa,et al.  Involvement of cis‐acting repressive element(s) in the 3′‐untranslated region of human connective tissue growth factor gene , 1999, FEBS letters.

[42]  L. Lau,et al.  The CCN family of angiogenic regulators: the integrin connection. , 1999, Experimental cell research.

[43]  L. Lau,et al.  Fisp12/Mouse Connective Tissue Growth Factor Mediates Endothelial Cell Adhesion and Migration through Integrin αvβ3, Promotes Endothelial Cell Survival, and Induces Angiogenesis In Vivo , 1999, Molecular and Cellular Biology.

[44]  D. Brigstock.  The Connective Tissue Growth Factor/cysteine- Rich 61/nephroblastoma Overexpressed (ccn) Family* , 2022 .

[45]  F. Martin,et al.  Suppression Subtractive Hybridization Identifies High Glucose Levels as a Stimulus for Expression of Connective Tissue Growth Factor and Other Genes in Human Mesangial Cells* , 1999, The Journal of Biological Chemistry.

[46]  H. Hameister,et al.  Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells , 1999, Oncogene.

[47]  D. Brigstock,et al.  Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. , 1999, Growth factors.

[48]  M. Uzumcu,et al.  Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings. , 1998, Biology of reproduction.

[49]  Gary R. Grotendorst,et al.  Inhibition of TGF‐β‐stimulated CTGF gene expression and anchorage‐independent growth by cAMP identifies a CTGF‐dependent restriction point in the cell cycle , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  Gary R. Grotendorst,et al.  Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease? , 1998, The international journal of biochemistry & cell biology.

[51]  M. Brauchle,et al.  Dexamethasone Is a Novel Potent Inducer of Connective Tissue Growth Factor Expression , 1998, The Journal of Biological Chemistry.

[52]  E. Wilson,et al.  Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells. , 1998, The Journal of clinical endocrinology and metabolism.

[53]  M. Takigawa,et al.  Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8). , 1998, Biochemical and biophysical research communications.

[54]  R. Ziegler,et al.  Molecular cloning of genes differentially regulated by TNF-alpha in bovine aortic endothelial cells, fibroblasts and smooth muscle cells. , 1998, Cardiovascular research.

[55]  R. Bende,et al.  Expression of connective tissue growth factor in human renal fibrosis. , 1998, Kidney international.

[56]  K. Takehara,et al.  Differential expression of connective tissue growth factor gene in cutaneous fibrohistiocytic and vascular tumors , 1998, Journal of cutaneous pathology.

[57]  T. Lüscher,et al.  Connective tissue growth factor. Friend or foe? , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[58]  W. März,et al.  Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. , 1997, Circulation.

[59]  Gary R. Grotendorst,et al.  Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. , 1996, The Journal of investigative dermatology.

[60]  Gary R. Grotendorst,et al.  Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. , 1996, The Journal of investigative dermatology.

[61]  Gary R. Grotendorst,et al.  A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[62]  Gary R. Grotendorst,et al.  Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. , 1995, The Journal of investigative dermatology.

[63]  H. Ihn,et al.  Growth regulation in scleroderma fibroblasts: increased response to transforming growth factor-beta 1. , 1995, The Journal of investigative dermatology.

[64]  P. Bork.  The modular architecture of a new family of growth regulators related to connective tissue growth factor , 1993, FEBS letters.

[65]  Gary R. Grotendorst,et al.  Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. , 1993, Molecular biology of the cell.

[66]  Gary R. Grotendorst,et al.  Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10 , 1991, The Journal of cell biology.