Assessment of ENDPs in Animal Models of Disease

[1]  M. Peitsch,et al.  Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke , 2020, Toxicological sciences : an official journal of the Society of Toxicology.

[2]  M. Peitsch,et al.  Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice , 2020, Toxicological sciences : an official journal of the Society of Toxicology.

[3]  S. Braman,et al.  Recent Advances in the Management of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. , 2020, The Medical clinics of North America.

[4]  N. Câmara,et al.  Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model , 2020, PloS one.

[5]  Q. Cui,et al.  Ciprofibrate attenuates airway remodeling in cigarette smoke-exposed rats , 2020, Respiratory Physiology & Neurobiology.

[6]  M. Peitsch,et al.  A 6-month systems toxicology inhalation study in ApoE-/- mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke. , 2020, American journal of physiology. Heart and circulatory physiology.

[7]  M. Peitsch,et al.  Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke. , 2019, Chemico-biological interactions.

[8]  Zhihui He,et al.  Animal models of emphysema , 2019, Chinese medical journal.

[9]  P. Babál,et al.  E-Cigarettes and Cancer Risk , 2019, Cancer Prevention Research.

[10]  J. Paramio,et al.  Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes , 2019, Proceedings of the National Academy of Sciences.

[11]  A. Moreira,et al.  Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice , 2019, Proceedings of the National Academy of Sciences.

[12]  D. Corry,et al.  Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. , 2019, The Journal of clinical investigation.

[13]  I. Rahman,et al.  Dysregulated repair and inflammatory responses by e‐cigarette‐derived inhaled nicotine and humectant propylene glycol in a sex‐dependent manner in mouse lung , 2019, FASEB bioAdvances.

[14]  G. Jeschke,et al.  Comparison of Free Radical Levels in the Aerosol from Conventional Cigarettes, Electronic Cigarettes, and Heat-Not-Burn Tobacco Products , 2019, Chemical research in toxicology.

[15]  C. Rudin,et al.  Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data , 2019, Nature Reviews Cancer.

[16]  Deepak L. Bhatt,et al.  Arterial Inflammation: The Heat Before the Storm. , 2019, Journal of the American College of Cardiology.

[17]  Dave Singh,et al.  The pathology of small airways disease in COPD: historical aspects and future directions , 2019, Respiratory Research.

[18]  M. Peitsch,et al.  Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products , 2019, Internal and Emergency Medicine.

[19]  M. Peitsch,et al.  A six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[20]  I. Laher,et al.  Smoking and Endothelial Dysfunction. , 2019, Current vascular pharmacology.

[21]  M. Peitsch,et al.  Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols , 2018, Inhalation toxicology.

[22]  McGarry Houghton,et al.  Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer , 2018, Annals of the American Thoracic Society.

[23]  Rémi H. J. Dulize,et al.  In vitro systems toxicology-based assessment of the potential modified risk tobacco product CHTP 1.2 for vascular inflammation- and cytotoxicity-associated mechanisms promoting adhesion of monocytic cells to human coronary arterial endothelial cells. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  Esra A. Akbay,et al.  Autochthonous murine models for the study of smoker and never-smoker associated lung cancers. , 2018, Translational lung cancer research.

[25]  D. Droemann,et al.  E-cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: A randomized, double-blinded pilot study , 2018, Vascular medicine.

[26]  P. Libby,et al.  Atherosclerosis and inflammation: overview and updates. , 2018, Clinical science.

[27]  A. Luch,et al.  Levels of selected analytes in the emissions of “heat not burn” tobacco products that are relevant to assess human health risks , 2018, Archives of Toxicology.

[28]  F. Deleyiannis,et al.  The effects of electronic cigarette vapour on the lung: direct comparison to tobacco smoke , 2018, European Respiratory Journal.

[29]  P. Klinkhachorn,et al.  Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice. , 2018, Journal of applied physiology.

[30]  J. Lekakis,et al.  Electronic Cigarette Smoking Increases Arterial Stiffness and Oxidative Stress to a Lesser Extent Than a Single Conventional Cigarette: An Acute and Chronic Study. , 2018, Circulation.

[31]  L. Roth,et al.  Animal models of atherosclerosis. , 2017, European journal of pharmacology.

[32]  Li Yu,et al.  Smoking cessation affects the natural history of COPD , 2017, International journal of chronic obstructive pulmonary disease.

[33]  M. Peitsch,et al.  Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[34]  Barbara M. Bakker,et al.  Male apoE*3‐Leiden.CETP mice on high‐fat high‐cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men , 2017, Physiological Reports.

[35]  W. E. Stephens Comparing the cancer potencies of emissions from vapourised nicotine products including e-cigarettes with those of tobacco smoke , 2017, Tobacco Control.

[36]  V. Muzykantov,et al.  Targeting vascular (endothelial) dysfunction , 2017, British journal of pharmacology.

[37]  B. Zhou,et al.  Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes , 2017, Molecular medicine reports.

[38]  X. Saelens,et al.  Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration. , 2017, Journal of visualized experiments : JoVE.

[39]  K. Garcia,et al.  Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer , 2017, Nature.

[40]  M. Peitsch,et al.  Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[41]  M. Martins,et al.  A murine model of elastase- and cigarette smoke-induced emphysema , 2017, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.

[42]  Francesco Faita,et al.  Ultrasound-based Pulse Wave Velocity Evaluation in Mice. , 2017, Journal of visualized experiments : JoVE.

[43]  Kristofer C. Berrett,et al.  MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. , 2017, Cancer cell.

[44]  A. Pitt,et al.  Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds. , 2017, Free radical biology & medicine.

[45]  Julia Hoeng,et al.  Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke. , 2016, Regulatory toxicology and pharmacology : RTP.

[46]  M. Peitsch,et al.  Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program. , 2016, Regulatory toxicology and pharmacology : RTP.

[47]  P. Vanscheeuwijck,et al.  Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol. , 2016, Regulatory toxicology and pharmacology : RTP.

[48]  J. Schaller,et al.  Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol. , 2016, Regulatory toxicology and pharmacology : RTP.

[49]  Julia Hoeng,et al.  Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke. , 2016, Regulatory toxicology and pharmacology : RTP.

[50]  A. Berns,et al.  SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin , 2016, Cancer cell.

[51]  F. Violi,et al.  Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function. , 2016, Chest.

[52]  M. Campos,et al.  Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner , 2016, Thorax.

[53]  M. Peitsch,et al.  Quantitative proteomics analysis using 2D-PAGE to investigate the effects of cigarette smoke and aerosol of a prototypic modified risk tobacco product on the lung proteome in C57BL/6 mice. , 2016, Journal of proteomics.

[54]  C. Vlachopoulos,et al.  Electronic Cigarette Smoking Increases Aortic Stiffness and Blood Pressure in Young Smokers. , 2016, Journal of the American College of Cardiology.

[55]  K. Pinkerton,et al.  Temporal and Spatial Expression of Transforming Growth Factor-β after Airway Remodeling to Tobacco Smoke in Rats. , 2016, American journal of respiratory cell and molecular biology.

[56]  Ashraf Elamin,et al.  An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/− Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[57]  M. Peitsch,et al.  The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction , 2016, Journal of Translational Medicine.

[58]  M. Stratton,et al.  Mutational signatures associated with tobacco smoking in human cancer , 2016, Science.

[59]  G. Getz,et al.  ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis , 2016, Journal of Lipid Research.

[60]  J. Minna,et al.  From Mice to Men and Back: An Assessment of Preclinical Model Systems for the Study of Lung Cancers , 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[61]  Manuel C. Peitsch,et al.  Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice , 2016, Scientific Data.

[62]  M. Peitsch,et al.  Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells. , 2016, Toxicology.

[63]  P. Lilly,et al.  Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats , 2016, Inhalation toxicology.

[64]  G. O'Connor,et al.  The Health Effects of Electronic Cigarettes. , 2016, The New England journal of medicine.

[65]  I. Adcock,et al.  The relationship between COPD and lung cancer , 2015, Lung cancer.

[66]  D. Granger,et al.  Reperfusion injury and reactive oxygen species: The evolution of a concept☆ , 2015, Redox biology.

[67]  M. Peitsch,et al.  Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[68]  M. Ochs,et al.  A review of recent developments and applications of morphometry/stereology in lung research. , 2015, American journal of physiology. Lung cellular and molecular physiology.

[69]  Martin Vingron,et al.  Comprehensive genomic profiles of small cell lung cancer , 2015, Nature.

[70]  S. Bozinovski,et al.  Preclinical murine models of Chronic Obstructive Pulmonary Disease. , 2015, European journal of pharmacology.

[71]  A. Berns,et al.  Origins, genetic landscape, and emerging therapies of small cell lung cancer , 2015, Genes & development.

[72]  Ashraf Elamin,et al.  A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. , 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[73]  M. Peitsch,et al.  Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains , 2015, Inflammation Research.

[74]  D. Morris,et al.  Preclinical Murine Models for Lung Cancer: Clinical Trial Applications , 2015, BioMed research international.

[75]  Jennifer Park,et al.  Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems , 2015, Database J. Biol. Databases Curation.

[76]  K. Farsalinos,et al.  Nicotine Levels and Presence of Selected Tobacco-Derived Toxins in Tobacco Flavoured Electronic Cigarette Refill Liquids , 2015, International journal of environmental research and public health.

[77]  G. Peces-Barba,et al.  Modelos animales de enfermedad pulmonar obstructiva crónica , 2015 .

[78]  B. Celli,et al.  Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. , 2015, American journal of respiratory and critical care medicine.

[79]  V. Fuster,et al.  Induction of Sustained Hypercholesterolemia by Single Adeno-Associated Virus–Mediated Gene Transfer of Mutant hPCSK9 , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[80]  J. Etter,et al.  Electronic cigarettes: review of use, content, safety, effects on smokers and potential for harm and benefit. , 2014, Addiction.

[81]  Thomas M. Keane,et al.  The mutational landscapes of genetic and chemical models of Kras-driven lung cancer , 2014, Nature.

[82]  J. Jukema,et al.  Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin , 2014, European heart journal.

[83]  Gerald A Long,et al.  Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air. , 2014, Regulatory toxicology and pharmacology : RTP.

[84]  Yian Wang,et al.  Dietary Diindolylmethane Suppresses Inflammation-Driven Lung Squamous Cell Carcinoma in Mice , 2014, Cancer Prevention Research.

[85]  F. Faita,et al.  Non-invasive assessment of pulse wave velocity in mice by means of ultrasound images. , 2014, Atherosclerosis.

[86]  A. Papavassiliou,et al.  Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches. , 2014, Current medicinal chemistry.

[87]  Andrzej Sobczak,et al.  Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. , 2014, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[88]  Yun Lu,et al.  The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2 , 2014, Genes & development.

[89]  Steven J. M. Jones,et al.  Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.

[90]  Carine Poussin,et al.  A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability , 2014, Journal of Translational Medicine.

[91]  Kristofer C. Berrett,et al.  Sox2 Cooperates with Lkb1 Loss in a Mouse Model of Squamous Cell Lung Cancer , 2014, Cell reports.

[92]  M. Peitsch,et al.  Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model , 2014, Interdisciplinary toxicology.

[93]  P. Hansbro,et al.  Animal models of chronic obstructive pulmonary disease , 2014, Expert opinion on drug discovery.

[94]  Shohei Koyama,et al.  Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. , 2014, Cancer cell.

[95]  J. Mikkelsen,et al.  Induction of Atherosclerosis in Mice and Hamsters Without Germline Genetic Engineering , 2014, Circulation research.

[96]  A. McKenna,et al.  Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing , 2014, Cell.

[97]  M. Ochs,et al.  Alterations of mouse lung tissue dimensions during processing for morphometry: a comparison of methods. , 2014, American journal of physiology. Lung cellular and molecular physiology.

[98]  Julia Hoeng,et al.  Case study: the role of mechanistic network models in systems toxicology. , 2014, Drug discovery today.

[99]  S. Bozinovski,et al.  Recent advances in pre-clinical mouse models of COPD , 2013, Clinical science.

[100]  M. Ochs Estimating structural alterations in animal models of lung emphysema. Is there a gold standard? , 2014, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[101]  M. Peitsch,et al.  Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation. , 2013, Toxicology.

[102]  Jianxin Diao,et al.  Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice by upregulating visfatin expression , 2013, Cell Stress and Chaperones.

[103]  A. von Eckardstein,et al.  A Three-Dimensional Engineered Artery Model for In Vitro Atherosclerosis Research , 2013, PloS one.

[104]  M. Ochs,et al.  Quantitative microscopy of the lung: a problem-based approach. Part 2: stereological parameters and study designs in various diseases of the respiratory tract. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[105]  M. Peitsch,et al.  Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation. , 2013, Atherosclerosis.

[106]  Matthias Ochs,et al.  Quantitative microscopy of the lung: a problem-based approach. Part 1: basic principles of lung stereology. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[107]  Christine E. Becker,et al.  CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation , 2013, Nature Immunology.

[108]  A. Condliffe,et al.  The neutrophil in chronic obstructive pulmonary disease. , 2013, American journal of respiratory cell and molecular biology.

[109]  Travis J Cohoon,et al.  The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. , 2013, Cancer cell.

[110]  A. Berns,et al.  Mouse models for lung cancer , 2013, Molecular oncology.

[111]  W. Travis,et al.  New pathologic classification of lung cancer: relevance for clinical practice and clinical trials. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[112]  S. Gebel,et al.  Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse. , 2013, Toxicology.

[113]  S. Gebel,et al.  Lung Inflammatory Effects, Tumorigenesis, and Emphysema Development in a Long-Term Inhalation Study with Cigarette Mainstream Smoke in Mice , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[114]  Stephen S Hecht,et al.  Lung carcinogenesis by tobacco smoke , 2012, International journal of cancer.

[115]  M. Peitsch,et al.  Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice. , 2012, Atherosclerosis.

[116]  P. Chuang,et al.  Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis , 2012, Proceedings of the National Academy of Sciences.

[117]  H. Morgenstern,et al.  Systematic Reviews and Meta-and Pooled Analyses Previous Lung Diseases and Lung Cancer Risk : A Pooled Analysis From the International Lung Cancer Consortium , 2012 .

[118]  A. Daugherty,et al.  Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke. , 2012, Toxicology.

[119]  Li Ding,et al.  Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers , 2012, Cell.

[120]  Robert Gentleman,et al.  Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer , 2012, Nature Genetics.

[121]  K. Cibulskis,et al.  Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer , 2012, Nature Genetics.

[122]  Julia Hoeng,et al.  A network-based approach to quantifying the impact of biologically active substances. , 2012, Drug discovery today.

[123]  Yun Lu,et al.  Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma , 2012, Proceedings of the National Academy of Sciences.

[124]  Thiago M. C. Pereira,et al.  Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging , 2011, Lipids in Health and Disease.

[125]  Dan Xu,et al.  Role of extracellular signal-regulated kinase 1/2 in cigarette smoke-induced mucus hypersecretion in a rat model. , 2011, Chinese medical journal.

[126]  P. Libby,et al.  Progress and challenges in translating the biology of atherosclerosis , 2011, Nature.

[127]  M. Véniant,et al.  A Volumetric Method for Quantifying Atherosclerosis in Mice by Using MicroCT: Comparison to En Face , 2011, PloS one.

[128]  T. Laino,et al.  A revisited picture of the mechanism of glycerol dehydration. , 2011, The journal of physical chemistry. A.

[129]  P. Devillier,et al.  Update on the roles of distal airways in COPD , 2011, European Respiratory Review.

[130]  Ian M. Adcock,et al.  Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights , 2011, Respiration.

[131]  A. Churg,et al.  Animal models of cigarette smoke-induced chronic obstructive pulmonary disease , 2010, Expert review of respiratory medicine.

[132]  S. Han,et al.  Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism. , 2010, Thrombosis research.

[133]  C. Coggins A further review of inhalation studies with cigarette smoke and lung cancer in experimental animals, including transgenic mice , 2010, Inhalation toxicology.

[134]  N. Žarković,et al.  Pathological aspects of lipid peroxidation , 2010, Free radical research.

[135]  H. Haussmann,et al.  Murine lung tumor response after exposure to cigarette mainstream smoke or its particulate and gas/vapor phase fractions. , 2010, Toxicology.

[136]  S. Tiberti,et al.  Oxidative stress and endothelial dysfunction: say NO to cigarette smoking! , 2010, Current pharmaceutical design.

[137]  A. Kraneveld,et al.  Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation , 2010, Respiratory research.

[138]  A. Daugherty,et al.  Dietary coenzyme Q10 does not protect against cigarette smoke-augmented atherosclerosis in apoE-deficient mice. , 2010, Free radical biology & medicine.

[139]  A. Sweet-Cordero,et al.  Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. , 2010, Cancer research.

[140]  Jilly F. Evans,et al.  Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung , 2010, Journal of Pharmacology and Experimental Therapeutics.

[141]  E. Weibel,et al.  American Thoracic Society Documents An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure , 2010 .

[142]  Matthias Ochs,et al.  Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach. , 2010, Journal of applied physiology.

[143]  M. Karin,et al.  Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. , 2010, Cancer cell.

[144]  E. Birney,et al.  A small cell lung cancer genome reports complex tobacco exposure signatures , 2009, Nature.

[145]  M. Decramer,et al.  Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. , 2010, American journal of respiratory cell and molecular biology.

[146]  M. Pino,et al.  Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract , 2009, Toxicologic pathology.

[147]  Kazuki Nakamura,et al.  Biochemical evidence of atherosclerosis progression mediated by increased oxidative stress in apolipoprotein E-deficient spontaneously hyperlipidemic mice exposed to chronic cigarette smoke. , 2009, Journal of pharmacological sciences.

[148]  S. Lebrun,et al.  Progression of atherosclerosis in the Apo E-/- model: 12-month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet. , 2009, Atherosclerosis.

[149]  M. Bosland,et al.  Strain-dependent differences in susceptibility to lung cancer in inbred mice exposed to mainstream cigarette smoke. , 2009, Cancer letters.

[150]  Shyam Biswal,et al.  Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[151]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[152]  D. Mozaffarian,et al.  Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2009, Circulation.

[153]  K. Moore,et al.  Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[154]  R. Laniado-Laborín Smoking and Chronic Obstructive Pulmonary Disease (COPD). Parallel Epidemics of the 21st Century , 2009, International journal of environmental research and public health.

[155]  R. Silverstein,et al.  CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. , 2008, The Journal of clinical investigation.

[156]  K. Yoshiura,et al.  Sequential and quantitative analysis of a murine model of elastase-induced emphysema. , 2008, Biological & pharmaceutical bulletin.

[157]  Jian-Ping Jin,et al.  Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI. , 2008, American journal of physiology. Heart and circulatory physiology.

[158]  A. Gazdar,et al.  Lung cancer in never smokers — a different disease , 2007, Nature Reviews Cancer.

[159]  S. De Flora,et al.  Potent carcinogenicity of cigarette smoke in mice exposed early in life. , 2007, Carcinogenesis.

[160]  L. Lerman,et al.  Smoking Is Associated With Epicardial Coronary Endothelial Dysfunction and Elevated White Blood Cell Count in Patients With Chest Pain and Early Coronary Artery Disease , 2007, Circulation.

[161]  S. Vatner,et al.  Inhibition of p38α MAPK rescues cardiomyopathy induced by overexpressed β2-adrenergic receptor, but not β1-adrenergic receptor , 2007 .

[162]  B. Wong Inhalation Exposure Systems: Design, Methods and Operation , 2007, Toxicologic pathology.

[163]  S. Shapiro,et al.  Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease , 2006, European Respiratory Journal.

[164]  A. Churg,et al.  Animal models of cigarette smoke-induced chronic obstructive lung disease. , 2007, Contributions to microbiology.

[165]  D. Leibfritz,et al.  Free radicals and antioxidants in normal physiological functions and human disease. , 2007, The international journal of biochemistry & cell biology.

[166]  H. Struijker‐Boudier,et al.  Expert consensus document on arterial stiffness: methodological issues and clinical applications. , 2006, European heart journal.

[167]  C. Mathers,et al.  Projections of Global Mortality and Burden of Disease from 2002 to 2030 , 2006, PLoS medicine.

[168]  G. Joos,et al.  Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice1 , 2006, The Journal of Immunology.

[169]  I. Rahman,et al.  Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. , 2006, American journal of physiology. Lung cellular and molecular physiology.

[170]  J. Vestbo,et al.  COPD: the dangerous underestimate of 15% , 2006, The Lancet.

[171]  G. Getz,et al.  Diet and Murine Atherosclerosis , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[172]  E. Onrat,et al.  Acute smoking-induced alterations in Doppler echocardiographic measurements in chronic smokers. , 2006, Texas Heart Institute journal.

[173]  J. Mauderly,et al.  Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways. , 2005, Carcinogenesis.

[174]  J. Friedland,et al.  Matrix metalloproteinases in destructive pulmonary pathology , 2005, Thorax.

[175]  H. Drexler,et al.  Evaluation of Tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with Pulsed Doppler Tei index. , 2005, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[176]  H. Witschi The complexities of an apparently simple lung tumor model: The A/J mouse. , 2005, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[177]  T. Dragani,et al.  Pas1 haplotype-dependent genetic predisposition to lung tumorigenesis in rodents: a meta-analysis. , 2005, Carcinogenesis.

[178]  G. Helm,et al.  Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility. , 2005, Biochemical and biophysical research communications.

[179]  A. Berns,et al.  Mouse models for human lung cancer. , 2005, Genes & development.

[180]  J. Austin,et al.  Influence of Type of Cigarette on Peripheral versus Central Lung Cancer , 2005, Cancer Epidemiology Biomarkers & Prevention.

[181]  S. Fineschi,et al.  Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants , 2005, European Respiratory Journal.

[182]  H. Haussmann,et al.  Mechanisms Involved in A/J Mouse Lung Tumorigenesis Induced by Inhalation of an Environmental Tobacco Smoke Surrogate , 2005, Inhalation toxicology.

[183]  S. Neubauer,et al.  Quantification and 3D Reconstruction of Atherosclerotic Plaque Components in Apolipoprotein E Knockout Mice Using Ex Vivo High-Resolution MRI , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[184]  E. Onrat,et al.  Effect of smoking on endothelial function and wall thickness of brachial artery. , 2004, Circulation journal : official journal of the Japanese Circulation Society.

[185]  M. Cosio,et al.  The development of emphysema in cigarette smoke-exposed mice is strain dependent. , 2004, American journal of respiratory and critical care medicine.

[186]  J. Mauderly,et al.  Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[187]  P. Ayres,et al.  Lung tumorigenicity in A/J and rasH2 transgenic mice following mainstream tobacco smoke inhalation. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[188]  N. Maeda,et al.  Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor. , 2004, Biochimica et biophysica acta.

[189]  R. Cardiff,et al.  Classification of Proliferative Pulmonary Lesions of the Mouse , 2004, Cancer Research.

[190]  J. Defesche Low-density lipoprotein receptor--its structure, function, and mutations. , 2004, Seminars in vascular medicine.

[191]  K. Pinkerton,et al.  Lung Tumor Response in Strain a Mice Exposed to Tobacco Smoke: Some Dose-Effect Relationships , 2004, Inhalation toxicology.

[192]  Gunnar Klein,et al.  Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in mice. , 2003, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[193]  J. Phillips,et al.  Rosiglitazone Reduces the Accelerated Neointima Formation After Arterial Injury in a Mouse Injury Model of Type 2 Diabetes , 2003, Circulation.

[194]  A. Berns,et al.  Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. , 2003, Cancer cell.

[195]  David Sahn,et al.  Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function. , 2003, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[196]  R. Sandhir,et al.  Effect of α-Tocopherol on the Cardiac Antioxidant Defense System and Atherogenic Lipids in Cigarette Smoke-Inhaling Mice , 2003, Inhalation toxicology.

[197]  Azra Mahmud,et al.  Effect of Smoking on Arterial Stiffness and Pulse Pressure Amplification , 2003, Hypertension.

[198]  A. Churg,et al.  Animal models of cigarette smoke-induced COPD. , 2002, Chest.

[199]  R. Watson,et al.  Side-Stream Cigarette Smoke Induces Dose–Response in Systemic Inflammatory Cytokine Production and Oxidative Stress , 2002, Experimental biology and medicine.

[200]  Andrew N. Carr,et al.  Evaluation of left ventricular diastolic function from spectral and color M-mode Doppler in genetically altered mice. , 2002, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[201]  M. S. Miller,et al.  A mouse lung tumor model of tobacco smoke carcinogenesis. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[202]  S. Gebel,et al.  Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[203]  R. Leboeuf,et al.  LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. , 2002, American journal of physiology. Endocrinology and metabolism.

[204]  G. Bensi,et al.  Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes , 2001, Oncogene.

[205]  P. Jeffery Remodeling in asthma and chronic obstructive lung disease. , 2001, American journal of respiratory and critical care medicine.

[206]  S. Khuder,et al.  Effect of smoking cessation on major histologic types of lung cancer. , 2001, Chest.

[207]  Joseph L. Goldstein,et al.  The Cholesterol Quartet , 2001, Science.

[208]  L. Fabbri,et al.  Cellular and structural bases of chronic obstructive pulmonary disease. , 2001, American journal of respiratory and critical care medicine.

[209]  A. Daugherty,et al.  Sidestream cigarette smoke accelerates atherogenesis in apolipoprotein E-/- mice. , 2001, Atherosclerosis.

[210]  W. Hsueh,et al.  Troglitazone Inhibits Formation of Early Atherosclerotic Lesions in Diabetic and Nondiabetic Low Density Lipoprotein Receptor–Deficient Mice , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[211]  S. Khuder,et al.  Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. , 2001, Lung cancer.

[212]  A. Geick,et al.  Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c- myc and epidermal growth factor in alveolar type II pneumocytes , 2001, British Journal of Cancer.

[213]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[214]  R. A. Miller,et al.  Respiratory System and Mesothelium , 2001 .

[215]  H. Wollersheim,et al.  Intima-media thickness of peripheral arteries in asymptomatic cigarette smokers. , 2000, Atherosclerosis.

[216]  T. Papadopoulos,et al.  Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[217]  T. Arai,et al.  Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[218]  F. Hahn,et al.  Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 rats. , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[219]  G. Hansson,et al.  Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice. , 1999, Atherosclerosis.

[220]  J. Lasky,et al.  Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor. , 1999, The American journal of pathology.

[221]  D. Harrison,et al.  Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. , 1999, Circulation.

[222]  P. Poredos,et al.  Smoking is Associated with Dose-Related Increase of Intima-Media Thickness and Endothelial Dysfunction , 1999, Angiology.

[223]  P. Ayres,et al.  The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) , 1999, Toxicological sciences : an official journal of the Society of Toxicology.

[224]  P. Parekh,et al.  Reversal of diet-induced obesity and diabetes in C57BL/6J mice. , 1998, Metabolism: clinical and experimental.

[225]  G. Snider,et al.  Remodeling of alveolar walls after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization. , 1998, American journal of respiratory and critical care medicine.

[226]  Stephen G. Young,et al.  A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet , 1998, Nature Medicine.

[227]  S. Srivastava,et al.  Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis. , 1998, Cancer letters.

[228]  C. Coggins A Review of Chronic Inhalation Studies with Mainstream Cigarett Smoke in Rats and Mice , 1998, Toxicologic pathology.

[229]  D. L. Wilson,et al.  C57BL/6 mice fed high fat diets as models for diabetes-accelerated atherosclerosis. , 1998, Atherosclerosis.

[230]  R. Bucala,et al.  Tobacco smoke is a source of toxic reactive glycation products. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[231]  R. Maronpot,et al.  The carcinogenic potential of the gas phase of environmental tobacco smoke. , 1997, Carcinogenesis.

[232]  J. Whitsett,et al.  Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha. , 1997, The American journal of pathology.

[233]  P. Saldiva,et al.  Pulmonary emphysema induced by passive smoking: an experimental study in rats. , 1997, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[234]  J. Breslow,et al.  The emergence of mouse models of atherosclerosis and their relevance to clinical research , 1997, Journal of internal medicine.

[235]  R. Maronpot,et al.  The carcinogenicity of environmental tobacco smoke. , 1997, Carcinogenesis.

[236]  S. Magdaleno,et al.  Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[237]  H. Just,et al.  Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. , 1996, Circulation.

[238]  S. Torp,et al.  Long-term effects of inhaled nicotine. , 1996, Life sciences.

[239]  S. Belinsky,et al.  Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse. , 1996, Cancer letters.

[240]  Y. Takeshima,et al.  Effects of K‐ras Gene Mutations in the Development of Lung Lesions Induced by 4‐(N‐ Methyl‐N‐nitrosamino)‐1‐(3‐pyridyl)‐1‐butanone in A/J Mice , 1996, Japanese journal of cancer research : Gann.

[241]  E M Rubin,et al.  Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. , 1995, Journal of lipid research.

[242]  A. Zeiher,et al.  Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. , 1995, Circulation.

[243]  M. D. de Santi,et al.  Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population. , 1995, Laboratory investigation; a journal of technical methods and pathology.

[244]  J. Escolar,et al.  Emphysema as a result of involuntary exposure to tobacco smoke: morphometrical study of the rat. , 1995, Experimental lung research.

[245]  S. Hecht,et al.  Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. , 1994, Carcinogenesis.

[246]  B. Wieringa,et al.  Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. , 1994, Atherosclerosis.

[247]  D K Burns,et al.  Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. , 1994, The Journal of clinical investigation.

[248]  J. Whitsett,et al.  Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. , 1994, The Journal of clinical investigation.

[249]  R. Ross,et al.  ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[250]  Z. Ronai,et al.  G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. , 1993, Carcinogenesis.

[251]  J. Naggert,et al.  Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice. , 1993, Journal of lipid research.

[252]  M. D. de Santi,et al.  The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[253]  J. K. Lloyd,et al.  Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis , 1992, The Lancet.

[254]  E. Rubin,et al.  Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.

[255]  J. Whitsett,et al.  Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. , 1992, Cancer research.

[256]  M. You,et al.  Mutagenesis of the K-ras protooncogene in mouse lung tumors induced by N-ethyl-N-nitrosourea or N-nitrosodiethylamine. , 1992, Carcinogenesis.

[257]  Jun-yan Hong,et al.  Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea. , 1992, Cancer research.

[258]  B. Greenspan,et al.  2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats , 1992 .

[259]  S. Rehm,et al.  Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. , 1991, The American journal of pathology.

[260]  A. Churg,et al.  Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig. , 1990, The American review of respiratory disease.

[261]  B. Paigen,et al.  Synthetic low and high fat diets for the study of atherosclerosis in the mouse. , 1990, Journal of lipid research.

[262]  Marshall W. Anderson,et al.  Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[263]  C. Coggins,et al.  Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats. , 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[264]  L. Stevenson,et al.  Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells. , 1988, The Journal of clinical investigation.

[265]  M. Feinglos,et al.  Diet-Induced Type II Diabetes in C57BL/6J Mice , 1988, Diabetes.

[266]  R. Williams,et al.  Quantitative assessment of atherosclerotic lesions in mice. , 1987, Atherosclerosis.

[267]  G. Snider,et al.  Animal models of emphysema. , 1986, The American review of respiratory disease.

[268]  R. Maronpot,et al.  Strain A mouse pulmonary tumor test results for chemicals previously tested in the National Cancer Institute carcinogenicity tests. , 1986, Journal of the National Cancer Institute.

[269]  B. Paigen,et al.  Variation in susceptibility to atherosclerosis among inbred strains of mice. , 1985, Atherosclerosis.

[270]  J. Minna,et al.  Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties. , 1985, Cancer research.

[271]  R. E. Kouri,et al.  Lung cancer model system using 3-methylcholanthrene in inbred strains of mice. , 1981, Cancer research.

[272]  T. Ogura,et al.  Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. , 1980, Cancer research.

[273]  D. Conning,et al.  Effect of glycerol on local and systemic carcinogenicity of topically applied tobacco condensate. , 1978, British Journal of Cancer.

[274]  T. Ogura,et al.  Induction of squamous cell carcinoma in the lung of C57BL/6 mice by intratracheal instillation of benzo[a]pyrene with charcoal powder. , 1977, Gan.

[275]  G. Stoner,et al.  Lung tumors in mice: application to carcinogenesis bioassay. , 1975, Advances in cancer research.

[276]  F. Stenbäck,et al.  Lack of toxicity and carcinogenicity of some commonly used cutaneous agents , 1974 .

[277]  A. Lansdown,et al.  Long-term toxicity of propylene glycol in rats. , 1972, Food and cosmetics toxicology.

[278]  J. Fawell,et al.  A simple apparatus for the inflation fixation of lungs at constant pressure , 1971, Laboratory animals.

[279]  P. Nettesheim,et al.  Induction of squamous cell carcinoma in the respiratory tract of mice. , 1971, Journal of the National Cancer Institute.

[280]  C. G. Loosli,et al.  Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration. , 1947, The Journal of pharmacology and experimental therapeutics.

[281]  A. A. Nelson,et al.  OBSERVATIONS ON THE CHRONIC TOXICITIES OF PROPYLENE GLYCOL, ETHYLENE GLYCOL, DIETHYLENE GLYCOL, ETHYLENE GLYCOL MONO-ETHYL-ETHER, AND DIETHYLENE GLYCOL MONO-ETHYL-ETHER , 1942 .