Primary human bone cultures from older patients do not respond at continuum levels of in vivo strain magnitudes.

[1]  A. Battmann,et al.  Endosteal human bone cells (EBC) show age-related activity in vitro. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[2]  C. Stanford,et al.  Significant role of adhesion properties of primary osteoblast-like cells in early adhesion events for chondroitin sulfate and dermatan sulfate surface molecules. , 1999, Journal of biomedical materials research.

[3]  T. Brown,et al.  Loading paradigms--intentional and unintentional--for cell culture mechanostimulus. , 1998, The American journal of the medical sciences.

[4]  M. Evans,et al.  Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro. , 1998, Bone.

[5]  R A Brand,et al.  A Cell Strain System for Small Homogeneous Strain Applications - Ein Zellstimulations-System zur Applikation kleiner homogener Dehnungen , 1997, Biomedizinische Technik. Biomedical engineering.

[6]  M. Hiriart,et al.  Experimental and Clinical Endocrinology and Diabetes , 1997 .

[7]  D. Burr,et al.  Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. , 1997, The American journal of physiology.

[8]  Y. Mikuni‐Takagaki,et al.  Distinct responses of different populations of bone cells to mechanical stress. , 1996, Endocrinology.

[9]  R. Brand,et al.  Cellular deformation reversibly depresses RT-PCR detectable levels of bone-related mRNA. , 1995, Journal of biomechanics.

[10]  R. Brand,et al.  Proliferative and phenotypic responses of bone‐like cells to mechanical deformation , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  L. Lanyon,et al.  Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[12]  C. Stanford,et al.  Bone Cell Expression on Titanium Surfaces is Altered by Sterilization Treatments , 1994, Journal of dental research.

[13]  R. Brand,et al.  How connective tissues temporally process mechanical stimuli. , 1994, Medical hypotheses.

[14]  J Y Rho,et al.  Mechanical loading thresholds for lamellar and woven bone formation , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  C Neidlinger-Wilke,et al.  Cyclic stretching of human osteoblasts affects proliferation and metabolism: A new experimental method and its application , 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  L. Lanyon,et al.  Early strain‐related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  C T Rubin,et al.  Characterizing bone strain distributions in vivo using three triple rosette strain gages. , 1992, Journal of biomechanics.

[18]  R A Brand,et al.  Autonomous informational stability in connective tissues. , 1992, Medical hypotheses.

[19]  S. Pollack,et al.  The proliferative and synthetic response of isolated calvarial bone cells of rats to cyclic biaxial mechanical strain. , 1991, The Journal of bone and joint surgery. American volume.

[20]  D. Jones,et al.  Biochemical signal transduction of mechanical strain in osteoblast-like cells. , 1991, Biomaterials.

[21]  John A. Kanis,et al.  Bone and Mineral Research , 1991 .

[22]  G. Stein,et al.  Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  A. Banes,et al.  Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. , 1988, Bone and mineral.

[24]  Frost Hm,et al.  The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. , 1987 .

[25]  L E Lanyon,et al.  Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling. , 1984, Journal of theoretical biology.

[26]  J. Lachin Introduction to sample size determination and power analysis for clinical trials. , 1981, Controlled clinical trials.

[27]  M. Singh,et al.  Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis. , 1970, The Journal of bone and joint surgery. American volume.

[28]  J. Wolff Das Gesetz der Transformation der Knochen , 1893 .

[29]  S. Cowin,et al.  Mechanotransduction in Bone , 1998 .

[30]  C T Rubin,et al.  Promotion of bony ingrowth by frequency-specific, low-amplitude mechanical strain. , 1994, Clinical orthopaedics and related research.

[31]  H. Frost,et al.  The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. , 1987, Bone and mineral.

[32]  P. Robey,et al.  Human bone cells in vitro. , 1985, Calcified tissue international.

[33]  T. Keller,et al.  In vivo strain gage implantation in rats. , 1982, Journal of biomechanics.

[34]  L E Lanyon,et al.  The relationship of functional stress and strain to the processes of bone remodelling. An experimental study on the sheep radius. , 1979, Journal of biomechanics.

[35]  A. Goodship,et al.  Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft. , 1975, Acta orthopaedica Scandinavica.

[36]  G V Cochran,et al.  Implantation of strain gages on bone in vivo. , 1972, Journal of biomechanics.