Event-Based Surveillance During EXPO Milan 2015: Rationale, Tools, Procedures, and Initial Results

More than 21 million participants attended EXPO Milan from May to October 2015, making it one of the largest protracted mass gathering events in Europe. Given the expected national and international population movement and health security issues associated with this event, Italy fully implemented, for the first time, an event-based surveillance (EBS) system focusing on naturally occurring infectious diseases and the monitoring of biological agents with potential for intentional release. The system started its pilot phase in March 2015 and was fully operational between April and November 2015. In order to set the specific objectives of the EBS system, and its complementary role to indicator-based surveillance, we defined a list of priority diseases and conditions. This list was designed on the basis of the probability and possible public health impact of infectious disease transmission, existing statutory surveillance systems in place, and any surveillance enhancements during the mass gathering event. This article reports the methodology used to design the EBS system for EXPO Milan and the results of 8 months of surveillance.

[1]  J. Schellekens,et al.  A large outbreak of Legionnaires' disease at a flower show, the Netherlands, 1999. , 2002, Emerging infectious diseases.

[2]  Steinberger Ralf,et al.  MedISys - Medical Information System , 2010 .

[3]  J S Brownstein,et al.  An overview of internet biosurveillance. , 2013, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[4]  Erik Van der Goot,et al.  Tracking Media Reports on the Shiga Toxin-Producing Escherichia coli O104: H4 Outbreak in Germany , 2011, eHealth.

[5]  C. Rizzo,et al.  An Early Warning System Based on Syndromic Surveillance to Detect Potential Health Emergencies among Migrants: Results of a Two-Year Experience in Italy , 2014, International journal of environmental research and public health.

[6]  K. Denecke,et al.  Social Media and Internet-Based Data in Global Systems for Public Health Surveillance: A Systematic Review , 2014, The Milbank quarterly.

[7]  BarkerMike,et al.  Interfacing a biosurveillance portal and an international network of institutional analysts to detect biological threats. , 2014 .

[8]  F. Ansaldi,et al.  Emergency department syndromic surveillance system for early detection of 5 syndromes: a pilot project in a reference teaching hospital in Genoa, Italy. , 2008, Journal of preventive medicine and hygiene.

[9]  A Mawudeku,et al.  Landscape of international event-based biosurveillance , 2010, Emerging health threats journal.

[10]  Son Doan,et al.  BioCaster: detecting public health rumors with a Web-based text mining system , 2008, Bioinform..

[11]  G. Rodier,et al.  Hot spots in a wired world: WHO surveillance of emerging and re-emerging infectious diseases. , 2001, The Lancet. Infectious diseases.

[12]  J. Schellekens,et al.  UvA-DARE ( Digital Academic Repository ) A large outbreak of Legionnaires ' disease at a flower show , the Netherlands , 1999 , 2001 .

[13]  David M. Hartley,et al.  Using social media and internet data for public health surveillance: the importance of talking. , 2014, The Milbank quarterly.

[14]  K. Ehresmann,et al.  An outbreak of measles at an international sporting event with airborne transmission in a domed stadium. , 1995, The Journal of infectious diseases.

[15]  P. Barboza,et al.  Interfacing a biosurveillance portal and an international network of institutional analysts to detect biological threats. , 2014, Biosecurity and bioterrorism : biodefense strategy, practice, and science.

[16]  E. Severi,et al.  Evaluation of the Health Protection Event-Based Surveillance for the London 2012 Olympic and Paralympic Games. , 2014, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[17]  D. Coulombier,et al.  Epidemic intelligence: a new framework for strengthening disease surveillance in Europe. , 2006, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[18]  J. Linge,et al.  Internet surveillance systems for early alerting of health threats. , 2009, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[19]  L. Madoff ProMED-mail: an early warning system for emerging diseases. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[20]  P. Pezzotti,et al.  Syndromic surveillance: sensitivity and positive predictive value of the case definitions , 2008, Epidemiology and Infection.

[21]  C. Martin 2015 , 2015, Les 25 ans de l’OMC: Une rétrospective en photos.

[22]  Nik Bessis,et al.  Advanced ICTs for Disaster Management and Threat Detection: Collaborative and Distributed Frameworks , 2010 .

[23]  A. Bella,et al.  Measles outbreak linked to an international dog show in Slovenia - primary cases and chains of transmission identified in Italy, November to December 2014. , 2015, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[24]  Herman D. Tolentino,et al.  Use of Unstructured Event-Based Reports for Global Infectious Disease Surveillance , 2009, Emerging infectious diseases.

[25]  William B. Lober,et al.  Roundtable on bioterrorism detection: information system-based surveillance. , 2002, Journal of the American Medical Informatics Association : JAMIA.

[26]  Elad Yom-Tov,et al.  Detecting Disease Outbreaks in Mass Gatherings Using Internet Data Monitoring , 2015 .

[27]  C. Rizzo,et al.  Syndromic surveillance of epidemic-prone diseases in response to an influx of migrants from North Africa to Italy, May to October 2011. , 2011, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[28]  J. Brownstein,et al.  Evaluation of Epidemic Intelligence Systems Integrated in the Early Alerting and Reporting Project for the Detection of A/H5N1 Influenza Events , 2013, PloS one.

[29]  K. Prosenc,et al.  An outbreak of measles associated with an international dog show in Slovenia, November 2014. , 2015, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[30]  M. Nicol,et al.  An outbreak of food poisoning among children attending an international sports event in Johannesburg. , 2001, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[31]  I. Nuttall International Health Regulations (2005): taking stock. , 2014, Bulletin of the World Health Organization.

[32]  P. Gautret,et al.  Outbreaks associated to large open air festivals, including music festivals, 1980 to 2012. , 2013, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[33]  S. Ostroff,et al.  Multistate measles outbreak associated with an international youth sporting event--Pennsylvania, Michigan, and Texas, August-September 2007. , 2008, MMWR. Morbidity and mortality weekly report.

[34]  J S Brownstein,et al.  HealthMap: the development of automated real-time internet surveillance for epidemic intelligence. , 2007, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[35]  R. Evans European Centre for Disease Prevention and Control. , 2014, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[36]  J. Linge,et al.  Enhanced epidemic intelligence using a web-based screening system during the 2010 FIFA World Cup in South Africa. , 2014, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[37]  A Economopoulou,et al.  Infectious diseases prioritisation for event-based surveillance at the European Union level for the 2012 Olympic and Paralympic Games. , 2014, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[38]  J. Kennedy Risk for meningococcal disease associated with the Hajj 2001. , 2001, MMWR. Morbidity and mortality weekly report.