DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway
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Z. Qin | Jun-chao Wu | Haidong Xu | H. She | Rong Han | Zhou Zhu | Ting-Jun Lu
[1] A. Cervantes,et al. NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer , 2018, Clinical Cancer Research.
[2] A. Cervantes,et al. RPS6 through the activation of NRF2 causes resistance to antiHER2 drugs in HER2 amplified gastric cancer (GC) models. , 2018, Annals of Oncology.
[3] David E. Williams,et al. Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane , 2018, Molecular biology of the cell.
[4] Z. Mao,et al. p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1 , 2018, The Journal of cell biology.
[5] T. Maffucci,et al. Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas , 2017, Cancers.
[6] David M. Sabatini,et al. mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.
[7] D. Sabatini,et al. mTOR Signaling in Growth, Metabolism, and Disease , 2017, Cell.
[8] M. Schweizer,et al. AR-Signaling in Human Malignancies: Prostate Cancer and Beyond , 2017, Cancers.
[9] A. Nishi,et al. PKA-Dependent Phosphorylation of Ribosomal Protein S6 Does Not Correlate with Translation Efficiency in Striatonigral and Striatopallidal Medium-Sized Spiny Neurons , 2015, Journal of Neuroscience.
[10] P. De Camilli,et al. Plasticity of PI4KIIIα interactions at the plasma membrane , 2015, EMBO reports.
[11] F. Carballo,et al. Resistance to Selumetinib (AZD6244) in Colorectal Cancer Cell Lines is Mediated by p70S6K and RPS6 Activation1 , 2014, Neoplasia.
[12] Z. Qin,et al. DRAM1 Regulates Autophagy Flux through Lysosomes , 2013, PloS one.
[13] Z. Qin,et al. The Pro-Survival Role of Autophagy Depends on Bcl-2 Under Nutrition Stress Conditions , 2013, PloS one.
[14] A. Maitra,et al. Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. , 2013, Cancer research.
[15] A. McEvoy,et al. The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells , 2013, Oncogene.
[16] M. Pollak. The insulin and insulin-like growth factor receptor family in neoplasia: an update , 2012, Nature Reviews Cancer.
[17] K. Ryan,et al. DRAM-1 encodes multiple isoforms that regulate autophagy , 2012, Autophagy.
[18] K. Mazan-Mamczarz,et al. Ribosomal protein S6 is highly expressed in non-Hodgkin lymphoma and associates with mRNA containing a 5′ terminal oligopyrimidine tract , 2011, Oncogene.
[19] R. Tibbetts,et al. Regulation of Ribosomal Protein S6 Phosphorylation by Casein Kinase 1 and Protein Phosphatase 1* , 2011, The Journal of Biological Chemistry.
[20] D. Klionsky,et al. Eaten alive: a history of macroautophagy , 2010, Nature Cell Biology.
[21] Kwok-Kin Wong,et al. Targeting the PI3K signaling pathway in cancer. , 2010, Current opinion in genetics & development.
[22] Sun-Mi Park,et al. Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death. , 2009, Biochemical and biophysical research communications.
[23] K. Ryan,et al. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy , 2009, Cell cycle.
[24] J. Guan,et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. , 2009, Molecular biology of the cell.
[25] L. Zhao,et al. Class I PI3K in oncogenic cellular transformation , 2008, Oncogene.
[26] Daniel J. Klionsky,et al. Autophagy fights disease through cellular self-digestion , 2008, Nature.
[27] J. Blenis,et al. RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation* , 2007, Journal of Biological Chemistry.
[28] M. Spinella,et al. The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins. , 2007, Biochimica et biophysica acta.
[29] Kevin M. Ryan,et al. DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis , 2006, Cell.
[30] Michael D. Schneider,et al. Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy , 2005, Cell.
[31] A. Levine,et al. The coordinate regulation of the p53 and mTOR pathways in cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[32] R. Baxter,et al. Cellular actions of the insulin-like growth factor binding proteins. , 2002, Endocrine reviews.
[33] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[34] Lewis C Cantley,et al. The phosphoinositide 3-kinase pathway. , 2002, Science.
[35] W. Lopaczynski,et al. Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. , 2000, Biochemical and biophysical research communications.
[36] Christine C. Hudson,et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. , 2000, Cancer research.
[37] P. Seglen,et al. Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, andN 6-Mercaptopurine Riboside , 1998, The Journal of Biological Chemistry.
[38] R. Roth,et al. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[39] A. Meijer,et al. Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*) , 1995, The Journal of Biological Chemistry.
[40] M. Siegmann,et al. Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[41] I. Wool,et al. The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated. , 1974, The Journal of biological chemistry.
[42] O. Meyuhas. Ribosomal Protein S6 Phosphorylation: Four Decades of Research. , 2015, International review of cell and molecular biology.
[43] O. Meyuhas. Physiological roles of ribosomal protein S6: one of its kind. , 2008, International review of cell and molecular biology.