Basal cell-signet-ring squamous cell carcinoma of the eyelid.

A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.

[1]  D. Sarma,et al.  Collision tumor of apocrine carcinoma and squamous carcinoma occurring in the ear. , 2004, American Journal of Otolaryngology.

[2]  P. Shepherd,et al.  Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin , 2000, Histopathology.

[3]  M. Maloney.  What is basosquamous carcinoma? , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[4]  Robert C. G. Martin,et al.  Basosquamous carcinoma , 2000, Cancer.

[5]  B. Bastian,et al.  Signet-ring cell formation in cutaneous neoplasms. , 1999, Journal of the American Academy of Dermatology.

[6]  J. Sinard.  Immunohistochemical distinction of ocular sebaceous carcinoma from basal cell and squamous cell carcinoma. , 1999, Archives of ophthalmology.

[7]  T. Bocklage,et al.  Signet‐ring squamous cell carcinoma: a case report , 1998, Journal of cutaneous pathology.

[8]  M. Maloney,et al.  The Immunohistochemical Characteristics of the Basosquamous Cell Carcinoma , 1997, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[9]  R. Kersten,et al.  Accuracy of clinical diagnosis of cutaneous eyelid lesions. , 1997, Ophthalmology.

[10]  G. Piérard,et al.  Collision of primary malignant neoplasms on the skin: the connection between malignant melanoma and basal cell carcinoma. , 1997, Dermatology.

[11]  R. Rapini,et al.  Cutaneous Collision Tumors: An Analysis of 69 Cases and Review of the Literature , 1994, The American Journal of dermatopathology.

[12]  C. Shields.  Basal Cell Carcinoma of the Eyelids , 1993, International ophthalmology clinics.

[13]  S. Cramer,et al.  Signet-ring squamous cell carcinoma. , 1989, American journal of clinical pathology.

[14]  W. Green,et al.  Squamous cell carcinoma of the eyelids. , 1987, Ophthalmology.