A soft deformable tissue-equivalent phantom for diffuse optical tomography

A recipe is presented for the manufacture of highly compressible phantoms for diffuse optical tomography. The recipe is based on polyvinyl alcohol (PVA) slime, a viscoelastic fluid which readily deforms under moderate pressure. Scattering particles and absorbing compounds can be added to provide a uniform material with stable and reproducible optical properties. A linear relationship between the concentration of scattering particles (either titanium dioxide or microspheres) and the transport scatter coefficient is demonstrated. Phantoms of an arbitrary size and shape may be produced by containing the slime within a thin latex shell, and a stability over a period of at least 3 months has been established. The deformable phantoms may be used to test and calibrate optical tomography systems designed for use on patients with irregular or variable geometries.

[1]  S R Arridge,et al.  Recent advances in diffuse optical imaging , 2005, Physics in medicine and biology.

[2]  R Marchesini,et al.  A phantom with tissue‐like optical properties in the visible and near infrared for use in photomedicine , 2001, Lasers in surgery and medicine.

[3]  Ram Mohan Vasu,et al.  Design, fabrication, and characterization of a tissue-equivalent phantom for optical elastography. , 2005, Journal of biomedical optics.

[4]  J C Hebden,et al.  Evaluating the spatial resolution performance of a time-resolved optical imaging system. , 1992, Medical physics.

[5]  Megha Singh,et al.  OPTICAL TISSUE-EQUIVALENT PHANTOMS FOR MEDICAL IMAGING , 2002 .

[6]  Fabrizio Martelli,et al.  Measurements of optical properties of high-density media. , 2003, Applied optics.

[7]  D. Delpy,et al.  An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging. , 1995, Physics in medicine and biology.

[8]  J C Hebden,et al.  Tissue phantom for optical diagnostics based on a suspension of microspheres with a fractal size distribution. , 2005, Journal of biomedical optics.

[9]  H. Rinneberg,et al.  Preparation of solid phantoms with defined scattering and absorption properties for optical tomography. , 1996, Physics in medicine and biology.

[10]  Wiendelt Steenbergen,et al.  Poly(vinyl alcohol) gels for use as tissue phantoms in photoacoustic mammography. , 2003, Physics in medicine and biology.

[11]  Yasuo Kuga,et al.  Attenuation constant of a coherent field in a dense distribution of particles , 1982 .

[12]  D. Delpy,et al.  A 32-channel time-resolved instrument for medical optical tomography , 2000 .

[13]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[14]  M. Huang,et al.  Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases. , 2003, Neoplasia.

[15]  Victor Chernomordik,et al.  Experimental evaluation of an anisotropic scattering model of a slab geometry. , 2004, Optics letters.

[16]  M. Ferrari,et al.  Principles, techniques, and limitations of near infrared spectroscopy. , 2004, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[17]  K. T. Moesta,et al.  Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients , 2005, Physics in medicine and biology.

[18]  Brian W Pogue,et al.  Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom. , 2003, Journal of biomedical optics.

[19]  E. Miller,et al.  Tomographic optical breast imaging guided by three-dimensional mammography. , 2003, Applied optics.

[20]  D. Delpy,et al.  A design for a stable and reproducible phantom for use in near infra-red imaging and spectroscopy , 1993 .

[21]  S L Jacques,et al.  Optical properties of intralipid: A phantom medium for light propagation studies , 1992, Lasers in surgery and medicine.

[22]  B. Pogue,et al.  Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities , 2003 .

[23]  S. Svanberg,et al.  Time-gated viewing studies on tissuelike phantoms. , 1996, Applied optics.

[24]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[25]  S. Shalev,et al.  Development of a tissue-equivalent phantom for diaphanography. , 1986, Medical physics.

[26]  Quan Zhang,et al.  Coregistered tomographic x-ray and optical breast imaging: initial results. , 2005, Journal of biomedical optics.

[27]  P. Barber.  Absorption and scattering of light by small particles , 1984 .

[28]  Alexander A Oraevsky,et al.  Optical and acoustic properties at 1064 nm of polyvinyl chloride-plastisol for use as a tissue phantom in biomedical optoacoustics , 2005, Physics in medicine and biology.

[29]  Alessandro Torricelli,et al.  Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions , 2005, Physics in medicine and biology.

[30]  Simon R. Arridge,et al.  Elsevier Editorial System(tm) for NeuroImage Manuscript Draft Manuscript Number: Title: THREE DIMENSIONAL OPTICAL IMAGING OF BLOOD VOLUME AND OXYGENATION IN THE NEONATAL BRAIN , 2005 .

[31]  Steven L. Jacques,et al.  The Potential Of Time-Resolved Reflectance Measurements For The Noninvasive Determination Of Tissue Optical Properties , 1989, Photonics West - Lasers and Applications in Science and Engineering.

[32]  R Cubeddu,et al.  A solid tissue phantom for photon migration studies. , 1997, Physics in medicine and biology.

[33]  V. Ntziachristos,et al.  Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Stephen J. Lomnes,et al.  Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons. , 2006, Journal of biomedical optics.

[35]  S. Arridge,et al.  INSTITUTE OF PHYSICS PUBLISHING PHYSICS IN MEDICINE AND BIOLOGY , 2003 .

[36]  S Zhong,et al.  Instrumentation and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography. , 2000, Applied optics.