论文信息 - A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine.

A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine.

AbstractThe human lens contains a group of fluorescent compounds, derived from tryptophan, which act to absorb UV light in the 300–400 nm region of the spectrum.1 The major component is the glucoside of 3-hydroxykynurenine (3HK), 3-hydroxykynurenine glucoside (3HKG).2In the lens, 3HKG represents a unique pathway of tryptophan metabolism. Smaller amounts of kynurenine and 3HK have been detected in human lens extracts.3,4 . More recently, a new UV-filter compound derived from tryptophan, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside (AHBG), was identified, and constitutes the second most abundant UV-filter in the human lens.5

J. Aquilina

[1] J. Carver,et al. Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine. , 1999, Biochemistry.

[2] J. Carver,et al. A new UV‐filter compound in human lenses , 1994, FEBS letters.

[3] R. Truscott,et al. Ultraviolet filter compounds in human lenses: 3-hydroxykynurenine glucoside formation , 1994, Vision Research.

[4] R. Truscott,et al. UV filters in human lenses: tryptophan catabolism. , 1993, Experimental eye research.

[5] RUTH VAN HEYNINGEN,et al. Fluorescent Glucoside in the Human Lens , 1971, Nature.