Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles

[1]  L. Kubin.  Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms. , 2016, Comprehensive Physiology.

[2]  C. Saper,et al.  A Novel Population of Wake-Promoting GABAergic Neurons in the Ventral Lateral Hypothalamus , 2016, Current Biology.

[3]  V. Fenik.  Revisiting Antagonist Effects in Hypoglossal Nucleus: Brainstem Circuit for the State-Dependent Control of Hypoglossal Motoneurons: A Hypothesis , 2015, Front. Neurol..

[4]  Christelle Anaclet,et al.  Basal forebrain control of wakefulness and cortical rhythms , 2015, Nature Communications.

[5]  P. Major,et al.  Biomarkers associated with obstructive sleep apnea and morbidities: a scoping review. , 2015, Sleep medicine.

[6]  R. Stornetta,et al.  Optogenetic stimulation of adrenergic C1 neurons causes sleep state-dependent cardiorespiratory stimulation and arousal with sighs in rats. , 2014, American journal of respiratory and critical care medicine.

[7]  Jun Lu,et al.  GABAergic parafacial zone is a medullary slow–wave–sleep promoting center , 2014, Nature Neuroscience.

[8]  M. Goetting,et al.  [Upper airway stimulation in obstructive sleep apnea]. , 2014, Laryngo- rhino- otologie.

[9]  L. Kubin,et al.  Lingual Muscle Activity Across Sleep–Wake States in Rats with Surgically Altered Upper Airway , 2014, Front. Neurol..

[10]  Atul Malhotra,et al.  Adult obstructive sleep apnoea , 2014, The Lancet.

[11]  W. Colmers.  Faculty Opinions recommendation of An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. , 2014 .

[12]  C. Iber,et al.  Hypoglossal nerve stimulation improves obstructive sleep apnea: 12‐month outcomes , 2014, Journal of sleep research.

[13]  A. Oliven,et al.  Upper Airway Control and Function : Implications for Sleep-Disordered Breathing Electrical stimulation of the hypoglossal nerve : a potential therapy , 2014 .

[14]  C. Ludlow,et al.  Upper Airway Control and Function : Implications for Sleep-Disordered Breathing Activation of upper airway muscles during breathing and swallowing , 2014 .

[15]  P. van de Heyning,et al.  Upper-airway stimulation for obstructive sleep apnea. , 2014, The New England journal of medicine.

[16]  Rajesh Kumar,et al.  Heart Rate Responses to Autonomic Challenges in Obstructive Sleep Apnea , 2013, PloS one.

[17]  A. Malhotra,et al.  Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. , 2013, American journal of respiratory and critical care medicine.

[18]  R. Stornetta,et al.  C1 neurons: the body’s EMTs , 2013 .

[19]  T. Young,et al.  Increased prevalence of sleep-disordered breathing in adults. , 2013, American journal of epidemiology.

[20]  L. Kubin,et al.  Evidence That Adrenergic Ventrolateral Medullary Cells Are Activated whereas Precerebellar Lateral Reticular Nucleus Neurons Are Suppressed during REM Sleep , 2013, PloS one.

[21]  S. Hughes,et al.  Identification of the mechanism mediating genioglossus muscle suppression in REM sleep. , 2013, American journal of respiratory and critical care medicine.

[22]  R. Stornetta,et al.  Selective Optogenetic Activation of Rostral Ventrolateral Medullary Catecholaminergic Neurons Produces Cardiorespiratory Stimulation in Conscious Mice , 2013, The Journal of Neuroscience.

[23]  Ilana B. Witten,et al.  Glutamatergic Neurotransmission between the C1 Neurons and the Parasympathetic Preganglionic Neurons of the Dorsal Motor Nucleus of the Vagus , 2013, The Journal of Neuroscience.

[24]  V. Fenik,et al.  Quantitative analysis of the excitability of hypoglossal motoneurons during natural sleep in the rat , 2013, Journal of Neuroscience Methods.

[25]  S. Veasey.  Piecing Together Phenotypes of Brain Injury and Dysfunction in Obstructive Sleep Apnea , 2012, Front. Neur..

[26]  L. Kubin,et al.  Inhibition of A5 Neurons Facilitates the Occurrence of REM Sleep-Like Episodes in Urethane-Anesthetized Rats: A New Role for Noradrenergic A5 Neurons? , 2012, Front. Neur..

[27]  R. Stickgold,et al.  Increased Sleep Fragmentation Leads to Impaired Off-Line Consolidation of Motor Memories in Humans , 2012, PloS one.

[28]  L. Kubin,et al.  Quantitative differences among EMG activities of muscles innervated by subpopulations of hypoglossal and upper spinal motoneurons during non-REM sleep - REM sleep transitions: a window on neural processes in the sleeping brain. , 2011, Archives italiennes de biologie.

[29]  J. Kirkness,et al.  Effect of age and weight on upper airway function in a mouse model. , 2011, Journal of applied physiology.

[30]  Linh Vong,et al.  Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons , 2011, Neuron.

[31]  L. Kubin,et al.  Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. , 2010, American journal of respiratory and critical care medicine.

[32]  Julia K. M. Chan,et al.  Motor unit recruitment in human genioglossus muscle in response to hypercapnia. , 2010, Sleep.

[33]  Allan R. Jones,et al.  A robust and high-throughput Cre reporting and characterization system for the whole mouse brain , 2009, Nature Neuroscience.

[34]  R. Stornetta,et al.  Photostimulation of channelrhodopsin‐2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats , 2009, The Journal of physiology.

[35]  A. Malhotra,et al.  The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. , 2009, Chest.

[36]  Allan I Pack,et al.  Obstructive sleep apnea and cardiovascular disease: a perspective and future directions. , 2009, Progress in cardiovascular diseases.

[37]  A. Pack,et al.  Altered upper airway and soft tissue structures in the New Zealand Obese mouse. , 2009, American journal of respiratory and critical care medicine.

[38]  L. Kubin,et al.  Inhibition of pontine noradrenergic A7 cells reduces hypoglossal nerve activity in rats , 2008, Neuroscience.

[39]  H. Steenland,et al.  Endogenous Glutamatergic Control of Rhythmically Active Mammalian Respiratory Motoneurons In Vivo , 2008, The Journal of Neuroscience.

[40]  L. Kubin,et al.  Fos expression in pontomedullary catecholaminergic cells following rapid eye movement sleep-like episodes elicited by pontine carbachol in urethane-anesthetized rats , 2008, Neuroscience.

[41]  R. Gorman,et al.  Neural drive to human genioglossus in obstructive sleep apnoea , 2007, The Journal of physiology.

[42]  L. Kubin,et al.  Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract , 2007, Journal of Chemical Neuroanatomy.

[43]  M. Raizada,et al.  Efferent projections of rat rostroventrolateral medulla C1 catecholamine neurons: Implications for the central control of cardiovascular regulation , 2006, The Journal of comparative neurology.

[44]  H. Steenland,et al.  Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states. , 2006, American journal of respiratory and critical care medicine.

[45]  L. Kubin,et al.  Noradrenergic, serotonergic and GABAergic antagonists injected together into the XII nucleus abolish the REM sleep‐like depression of hypoglossal motoneuronal activity , 2005, Journal of sleep research.

[46]  L. Kubin,et al.  REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. , 2005, American journal of respiratory and critical care medicine.

[47]  R. Horner,et al.  Role of endogenous serotonin in modulating genioglossus muscle activity in awake and sleeping rats. , 2005, American journal of respiratory and critical care medicine.

[48]  D. Gozal,et al.  Intermittent Hypoxia during Development Induces Long-Term Alterations in Spatial Working Memory, Monoamines, and Dendritic Branching in Rat Frontal Cortex , 2005, Pediatric Research.

[49]  D. White,et al.  Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea. , 2004, American journal of respiratory and critical care medicine.

[50]  L. Kubin,et al.  Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XII nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity. , 2004, Archives italiennes de biologie.

[51]  P. Nolan,et al.  Role of inhibitory amino acids in control of hypoglossal motor outflow to genioglossus muscle in naturally sleeping rats , 2003, The Journal of physiology.

[52]  Y. Lai,et al.  Changes in Inhibitory Amino Acid Release Linked to Pontine-Induced Atonia: An In Vivo Microdialysis Study , 2003, The Journal of Neuroscience.

[53]  P. Nolan,et al.  Glycine at hypoglossal motor nucleus: genioglossus activity, CO(2) responses, and the additive effects of GABA. , 2002, Journal of applied physiology.

[54]  L. Kubin,et al.  A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol. , 2002, Journal of applied physiology.

[55]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[56]  M. Xi,et al.  Hypoglossal motoneurons are postsynaptically inhibited during carbachol-induced rapid eye movement sleep , 1999, Neuroscience.

[57]  M. Bellingham,et al.  Presynaptic depression of excitatory synaptic inputs to rat hypoglossal motoneurons by muscarinic M2 receptors. , 1996, Journal of neurophysiology.

[58]  J. Feldman,et al.  Differential innervation of protruder and retractor muscles of the tongue in rat , 1995, The Journal of comparative neurology.

[59]  R. Miselis,et al.  Dendritic architecture of hypoglossal motoneurons projecting to extrinsic tongue musculature in the rat , 1994, The Journal of comparative neurology.

[60]  R. Giering,et al.  Hypoglossal and phrenic nerve responses to carotid baroreceptor stimulation. , 1993, Journal of applied physiology.

[61]  S. Manaker.,et al.  Origin of serotoninergic afferents to the hypoglossal nucleus in the rat , 1993, The Journal of comparative neurology.

[62]  A. Pack,et al.  Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition , 1993, Brain Research.

[63]  J. Haycock,et al.  Sources of noradrenergic afferents to the hypoglossal nucleus in the rat , 1992, Brain Research Bulletin.

[64]  D. White,et al.  Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). , 1992, The Journal of clinical investigation.

[65]  M. Chase,et al.  The postsynaptic inhibitory control of lumbar motoneurons during the atonia of active sleep: effect of strychnine on motoneuron properties , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[66]  R. Harper,et al.  Respiratory-related activity in hypoglossal neurons across sleep-waking states in cats , 1991, Brain Research.

[67]  S A Shea,et al.  Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea. , 1989, The Quarterly journal of medicine.

[68]  M. Chase,et al.  Evidence that glycine mediates the postsynaptic potentials that inhibit lumbar motoneurons during the atonia of active sleep , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[69]  P. Suratt,et al.  Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects. , 1988, The American review of respiratory disease.

[70]  N. Vøllestad,et al.  Motor Unit Recruitment , 1987 .

[71]  D. Reis,et al.  Organization of central adrenergic pathways: I. Relationships of ventrolateral medullary projections to the hypothalamus and spinal cord , 1987, The Journal of comparative neurology.

[72]  P. Reiner.  Correlational analysis of central noradrenergic neuronal activity and sympathetic tone in behaving cats , 1986, Brain Research.

[73]  D. Reis,et al.  Sympathoinhibition by A1-noradrenergic neurons is mediated by neurons in the C1 area of the rostral medulla. , 1985, Journal of the autonomic nervous system.

[74]  F. Bloom,et al.  Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[75]  Remmers Je,et al.  Pathogenesis of upper airway occlusion during sleep , 1978 .

[76]  R. M. Harper,et al.  The human tongue during sleep: Electromyographic activity of the genioglossus muscle , 1976, Experimental Neurology.

[77]  M. Chase,et al.  Postsynaptic inhibition of hypoglossal motoneurons produces atonia of the genioglossal muscle during rapid eye movement sleep. , 2015, Sleep.

[78]  A. Jordan,et al.  Discharge properties of upper airway motor units during wakefulness and sleep. , 2014, Progress in brain research.

[79]  L. Kubin.  Sleep-wake control of the upper airway by noradrenergic neurons, with and without intermittent hypoxia. , 2014, Progress in brain research.

[80]  D. Seth,et al.  Invited Review EB 2012 . C 1 neurons : the body ’ s EMTs , 2013 .

[81]  J. Dempsey,et al.  Pathophysiology of sleep apnea. , 2010, Physiological reviews.

[82]  B. Jacobs,et al.  Structure and function of the brain serotonin system. , 1992, Physiological reviews.

[83]  J. Remmers,et al.  Pathogenesis of upper airway occlusion during sleep. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.