Asthma research in China: A five‐year review

Asthma is one of the most common chronic diseases worldwide with increasing morbidity. China has the largest asthmatic population and is one of the countries with the highest asthma mortality. Fortunately, asthma research in China, both clinical and scientific, has developed markedly over the past few years. This has resulted in significant increases in our understanding of Chinese asthma prevalence, risk factors, control status, pathogenesis, and new prevention or treatment strategies. In this review, the major achievements of asthma research in China from 2008 to 2012 are summarized.

[1]  C. Bai,et al.  Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice , 2010, Journal of cellular and molecular medicine.

[2]  J. Bai,et al.  Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. , 2009, Tissue antigens.

[3]  Jing Gao,et al.  Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap , 2013, European Respiratory Journal.

[4]  A. Litonjua,et al.  Vitamin D Deficiency Is Associated with Decreased Lung Function in Chinese Adults with Asthma , 2010, Respiration.

[5]  Y. Li,et al.  Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population. , 2009, Tissue antigens.

[6]  G. Wong,et al.  Very low prevalence of asthma and allergies in schoolchildren from rural Beijing, China , 2009, Pediatric pulmonology.

[7]  L. Hua,et al.  Association of Five Single Nucleotide Polymorphism loci with Asthma in Children of Chinese Han Nationality , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[8]  Y. Lee,et al.  Gender Differences and Effect of Air Pollution on Asthma in Children with and without Allergic Predisposition: Northeast Chinese Children Health Study , 2011, PloS one.

[9]  N. Zhong,et al.  Prevalence of respiratory and atopic disorders in Chinese schoolchildren , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[10]  Chronic exposure to sulfur dioxide enhances airway hyperresponsiveness only in ovalbumin-sensitized rats. , 2012, Toxicology letters.

[11]  Xueping Zhou,et al.  DC‐derived TSLP promotes Th2 polarization in LPS‐primed allergic airway inflammation , 2012, European journal of immunology.

[12]  Ying-ying Lin,et al.  A Recombinant DNA Plasmid Encoding the Human Interleukin-5 Breaks Immunological Tolerance and Inhibits Airway Inflammation in a Murine Model of Asthma , 2007, International Archives of Allergy and Immunology.

[13]  Zhuge Xi,et al.  Adverse Effect of Nano-Silicon Dioxide on Lung Function of Rats with or without Ovalbumin Immunization , 2011, PloS one.

[14]  B. Li,et al.  IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma1 , 2008, The Journal of Immunology.

[15]  Youming Zhang,et al.  Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population , 2011, BMC Medical Genetics.

[16]  Yongge Liu,et al.  Induction of CD4+CD25+Foxp3+IL-10+ T Cells in HDM-Allergic Asthmatic Children with or without SIT , 2010, International Archives of Allergy and Immunology.

[17]  Y. Gong,et al.  Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study , 2009, BMC Medical Genetics.

[18]  Jian Wang,et al.  Mastic alleviates allergic inflammation in asthmatic model mice by inhibiting recruitment of eosinophils. , 2011, American journal of respiratory cell and molecular biology.

[19]  Yu Wang,et al.  The CKLF1‐C19 peptide attenuates allergic lung inflammation by inhibiting CCR3‐ and CCR4‐mediated chemotaxis in a mouse model of asthma , 2011, Allergy.

[20]  Hui-jun Liu,et al.  Downregulation of Integrin β4 Decreases the Ability of Airway Epithelial Cells to Present Antigens , 2012, PloS one.

[21]  H. Li,et al.  Two polymorphisms in the TIM‐4 gene are associated with asthma in a Chinese Han population , 2011, International journal of immunogenetics.

[22]  Dongmei Wang,et al.  Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice. , 2010, Journal of medicinal chemistry.

[23]  Y. Shi,et al.  A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR‐immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells , 2011, Clinical and experimental immunology.

[24]  Chaoqian Li,et al.  Therapeutic effects of inhaled inactivated Mycobacterium phlei in adult patients with moderate persistent asthma. , 2012, Immunotherapy.

[25]  X. Y. Li,et al.  Adenovirus‐mediated delivery of soluble ST2 attenuates ovalbumin‐induced allergic asthma in mice , 2012, Clinical and experimental immunology.

[26]  Li Yang,et al.  HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage. , 2012, Human immunology.

[27]  Huahao Shen,et al.  Inhibition of allergen-induced airway remodeling by neonatal bacillus Calmette-Guerin vaccination is associated with interferon-gamma-producing T cells but not regulatory T cells in mice. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[28]  Lu Yan-ming,et al.  The Effect of Specific Immunotherapy on Natural Killer T cells in Peripheral Blood of House Dust Mite-Sensitized Children with Asthma , 2012, Clinical & developmental immunology.

[29]  Junfeng Zhang,et al.  Locally instilled tumor necrosis factor‐α antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs , 2012, The journal of gene medicine.

[30]  Xiansheng Liu,et al.  Recombinant Adeno-Associated Virus Vector-Mediated Delivery of Antisense Interleukin-5 Gene Attenuates Airway Remodeling in Allergic Rats , 2010, International Archives of Allergy and Immunology.

[31]  M. Fukuda,et al.  Faculty Opinions recommendation of ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). , 2011 .

[32]  Z. Lei,et al.  Original article: SCF and IL‐31 rather than IL‐17 and BAFF are potential indicators in patients with allergic asthma , 2007, Allergy.

[33]  Yan-Li Li,et al.  Thymic Stromal Lymphopoietin Promotes Lung Inflammation Through Activation of Dendritic Cells , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[34]  H. Shen,et al.  Treatment with anti‐CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34+ progenitor cells in an allergic mouse model , 2008, Allergy.

[35]  Z. Fang,et al.  YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E , 2010, European Respiratory Journal.

[36]  Xingbin Hu,et al.  Suppression of allergic airway inflammation in a mouse model by Der p2 recombined BCG , 2009, Immunology.

[37]  Laiyu Liu,et al.  A mobile phone short message service improves perceived control of asthma: a randomized controlled trial. , 2012, Telemedicine journal and e-health : the official journal of the American Telemedicine Association.

[38]  H. Shen,et al.  Neonatal vaccination with Bacillus Calmette‐Guérin elicits long‐term protection in mouse‐allergic responses , 2008, Allergy.

[39]  Xin Zhou,et al.  1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model by suppressing the expression of inducible nitric oxide synthase. , 2008, Allergy and asthma proceedings.

[40]  Jie Yang,et al.  Recombinant human elafin protects airway epithelium integrity during inflammation , 2010, Molecular Biology Reports.

[41]  Qi-Ji Liu,et al.  Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population , 2012, Experimental lung research.

[42]  J. Li,et al.  A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China , 2009, Allergy.

[43]  J. Zhao,et al.  Status of asthma control in children and the effect of parents' knowledge, attitude, and practice (KAP) in China: a multicenter study. , 2012, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[44]  Li-hua Hu,et al.  Association and Gene-Gene Interactions of Eight Common Single-Nucleotide Polymorphisms with Pediatric Asthma in Middle China , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[45]  W. Lai,et al.  ISO-1, a Macrophage Migration Inhibitory Factor Antagonist, Inhibits Airway Remodeling in a Murine Model of Chronic Asthma , 2010, Molecular medicine.

[46]  Chi-Feng Liu,et al.  Effects of Acupuncture-like Transcutaneous Electrical Nerve Stimulation on Children with Asthma , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[47]  Zhang Dan,et al.  Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients , 2011, Cell Stress and Chaperones.

[48]  R. Pauwels,et al.  GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[49]  D. Xia,et al.  The Overexpression of Heparin-Binding Epidermal Growth Factor Is Responsible for Th17-Induced Airway Remodeling in an Experimental Asthma Model , 2010, The Journal of Immunology.

[50]  W. Li,et al.  Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[51]  H. Tse,et al.  Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Allergic Airway Inflammation in Mice , 2012, Stem cells.

[52]  Hongqiang Cheng,et al.  Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  C. Liu,et al.  Glucocorticoids inhibit degranulation of mast cells in allergic asthma via nongenomic mechanism , 2008, Allergy.

[54]  Zhenyu Liang,et al.  Erratum to: Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients , 2011, Cell Stress and Chaperones.

[55]  G. Tang,et al.  Membrane water permeability related to antigen‐presenting function of dendritic cells , 2008, Clinical and experimental immunology.

[56]  Liyun Shi,et al.  Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. , 2008, Clinical immunology.

[57]  E. Liu,et al.  The Antiasthma Effect of Neonatal BCG Vaccination Does Not Depend on the Th17/Th1 but IL-17/IFN-γ Balance in a BALB/c Mouse Asthma Model , 2011, Journal of Clinical Immunology.

[58]  L. Wood,et al.  Soluble RAGE is deficient in neutrophilic asthma and COPD , 2011, European Respiratory Journal.

[59]  Hua-Hao Shen,et al.  Effect of Astragali-Cordyceps Mixtura on TGF-beta/Smad signal pathway in the lung of asthma airway remodeling. , 2009, Journal of Ethnopharmacology.

[60]  H. Upur,et al.  Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma , 2010, Evidence-based complementary and alternative medicine : eCAM.

[61]  G. Jin,et al.  Association between polymorphisms in IL17F and male asthma in a Chinese population. , 2012, Journal of investigational allergology & clinical immunology.

[62]  B. Chiang,et al.  Lentiviral-mediated interleukin-4 and interleukin-13 RNA interference decrease airway inflammation and hyperresponsiveness. , 2011, Human gene therapy.

[63]  Ming Yan,et al.  Correlation between serum H2S and pulmonary function in children with bronchial asthma. , 2012, Molecular medicine reports.

[64]  N. Zhong,et al.  Specific IgG4 Production during House Dust Mite Immunotherapy among Age, Gender and Allergic Disease Populations , 2012, International Archives of Allergy and Immunology.

[65]  Z. Qiu,et al.  Protein tyrosine phosphatase SHP2 regulates TGF‐β1 production in airway epithelia and asthmatic airway remodeling in mice , 2012, Allergy.

[66]  Miao-miao Wei,et al.  Different Effects of Farrerol on an OVA-Induced Allergic Asthma and LPS-induced Acute Lung Injury , 2012, PloS one.

[67]  Z. Qiu,et al.  Distant lymph nodes serve as pools of Th1 cells induced by neonatal BCG vaccination for the prevention of asthma in mice , 2013, Allergy.

[68]  Wen Li,et al.  Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition. , 2008, Journal of ethnopharmacology.

[69]  S. Geng,et al.  Protein/DNA vaccine‐induced antigen‐specific Treg confer protection against asthma , 2008, European journal of immunology.

[70]  C. Chen,et al.  Myosin Light Chain Kinase Is Necessary for Tonic Airway Smooth Muscle Contraction* , 2009, The Journal of Biological Chemistry.

[71]  Han Jian.  Observation on effect of acupuncture at Yuji (LU 10) on the pulmonary function of patients with bronchial asthma and immediate efficacy of relieving asthma , 2012 .

[72]  Jing Zhao,et al.  Self-reported prevalence of childhood allergic diseases in three cities of China: a multicenter study , 2010, BMC public health.

[73]  E. Liu,et al.  Therapeutic Effect of Intratracheal Administration of Murine IL-4 Receptor Antagonist on Asthmatic Airway Inflammation , 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

[74]  F. Jiang,et al.  Prevalence and risk factors of childhood allergic diseases in eight metropolitan cities in China: A multicenter study , 2011, BMC public health.

[75]  G. Jin,et al.  Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. , 2010, Journal of investigational allergology & clinical immunology.

[76]  Chang-zheng Wang,et al.  1,25-dihydroxyvitamin D₃ pretreatment enhances the efficacy of allergen immunotherapy in a mouse allergic asthma model. , 2010, Chinese medical journal.

[77]  Zhidong Lv,et al.  Astragalus Extract Attenuates Allergic Airway Inflammation and Inhibits Nuclear Factor &kgr;B Expression in Asthmatic Mice , 2013, The American journal of the medical sciences.

[78]  X. Wang,et al.  Potential therapy of Fc‐antigen combination‐encoding DNA vaccination in mouse allergic airway inflammation , 2008, Clinical and experimental immunology.

[79]  N. Zhong,et al.  Prior SO2 exposure promotes airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[80]  W. Gu,et al.  Fringe Controls Naïve CD4+T Cells Differentiation through Modulating Notch Signaling in Asthmatic Rat Models , 2012, PloS one.

[81]  D. Erle,et al.  Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[82]  Xiaofeng Jiang,et al.  Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children , 2009, Molecular Biology Reports.

[83]  E. Liu,et al.  The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis , 2010, Journal of Clinical Immunology.

[84]  Mingcai Li,et al.  Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. , 2009, Biochemical and biophysical research communications.