Surface-enhanced Raman spectroscopy of pterins

Raman spectroscopy is a useful technique in the identification and characterisation of compounds, but in terms of sensitivity its application is limited. With respect to this the discovery of the surface-enhanced Raman scattering (SERS) phenomenon has proved monumental, and much research has been carried out over the past 30 years developing the technique. Pterins are biological compounds that are found in nature in colour pigmentation and in mammalian metabolic pathways. Moreover, they have been identified in abnormal concentrations in cancer patients, suggesting potential applications in cancer diagnostics. SERS is an ideal technique to identify these compounds, and both nanoparticle suspensions and pulsed laser deposited nanoparticle substrates have been used to examine the spectra of xanthopterin, both in aqueous solution and in different pH environments.

[1]  Brendan Doggett,et al.  Pulsed laser deposition of nanostructured Ag films , 2006 .

[2]  Steven E. J. Bell,et al.  Quantitative Surface‐Enhanced Raman Spectroscopy , 2008 .

[3]  P. A. Atanasov,et al.  Femtosecond laser ablation of nickel in vacuum , 2007 .

[4]  Sanjeewa Gamagedara,et al.  Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[5]  R. Wadsworth,et al.  In situ detection of pterins by SERS. , 2009, The Analyst.

[6]  Bernhard Lendl,et al.  A New Method for Fast Preparation of Highly Surface-Enhanced Raman Scattering (SERS) Active Silver Colloids at Room Temperature by Reduction of Silver Nitrate with Hydroxylamine Hydrochloride , 2003 .

[7]  F. Rosei,et al.  Growth dynamics of pulsed laser deposited Pt nanoparticles on highly oriented pyrolitic graphite substrates , 2004 .

[8]  E. Oliveros,et al.  Fluorescence of pterin, 6-formylpterin, 6-carboxypterin and folic acid in aqueous solution: pH effects , 2002, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[9]  D. J. Bergman,et al.  Xanthopterin in the Oriental Hornet (Vespa orientalis): Light Absorbance Is Increased with Maturation of Yellow Pigment Granules , 2009, Photochemistry and photobiology.

[10]  S. Bell,et al.  Pterin detection using surface-enhanced Raman spectroscopy incorporating a straightforward silver colloid-based synthesis technique. , 2011, Journal of biomedical optics.