Noncontact photoacoustic imaging by using a modified optical-fiber Michelson interferometer

We demonstrate a noncontact photoacoustic imaging (PAI) system in which an optical interferometer is used for ultrasound detection. The system is based on a modified optical-fiber Michelson interferometer that measures the surface displacement caused by photoacoustic pressure. A synchronization method is utilized to keep its high sensitivity to reduce the influence of ambient vibrations. The system is experimentally verified by imaging of a phantom. The experimental results indicate that the proposed system can be used for noncontact PAI with high resolution and high bandwidth.

[1]  Markus Haltmeier,et al.  Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector. , 2007, Applied optics.

[2]  Lihong V. Wang,et al.  Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging , 2006, Nature Biotechnology.

[3]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .

[4]  Lihong V. Wang,et al.  Second generation optical-resolution photoacoustic microscopy , 2011, BiOS.

[5]  Lihong V. Wang,et al.  Photoacoustic imaging in biomedicine , 2006 .

[6]  Stefan A. Carp,et al.  Optoacoustic imaging using interferometric measurement of surface displacement , 2004 .

[7]  Todd N. Erpelding,et al.  Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system , 2010, Biomedical optics express.

[8]  Jan Laufer,et al.  Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues. , 2008, Applied optics.

[9]  Lihong V. Wang Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[10]  Junjie Yao,et al.  Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. , 2011, Blood.

[11]  Sridhar Krishnaswamy,et al.  Heterodyne interferometer with two‐wave mixing in photorefractive crystals for ultrasound detection on rough surfaces , 1996 .

[12]  Lihong V. Wang,et al.  Prospects of photoacoustic tomography. , 2008, Medical physics.

[13]  Lihong V. Wang,et al.  Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries. , 2008, Optics letters.

[14]  Ruikang K. Wang,et al.  Noncontact photoacoustic imaging achieved by using a low-coherence interferometer as the acoustic detector. , 2011, Optics letters.

[15]  Thomas Berer,et al.  Remote photoacoustic imaging on solid material using a two-wave mixing interferometer. , 2010, Optics letters.