Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

[1]  A. Venerosi,et al.  Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014 , 2020, Brain sciences.

[2]  I. Hertz-Picciotto,et al.  Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome , 2019, Translational Psychiatry.

[3]  M. Radkowski,et al.  Gut Microbiota in Neurological Disorders , 2019, Archivum Immunologiae et Therapiae Experimentalis.

[4]  J. Sebat,et al.  Getting to the Cores of Autism , 2019, Cell.

[5]  Bradley J. Ferguson,et al.  Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder , 2019, Front. Psychiatry.

[6]  P. Khaitovich,et al.  Metabolome signature of autism in the human prefrontal cortex , 2019, Communications Biology.

[7]  Young-Mo Kim,et al.  Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice , 2019, Cell.

[8]  G. Wang,et al.  Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis. , 2019, The Journal of nutritional biochemistry.

[9]  A. Litonjua,et al.  Metabolomics and Communication Skills Development in Children; Evidence from the Ages and Stages Questionnaire , 2019, Metabolites.

[10]  D. Amaral,et al.  Amino Acid Dysregulation Metabotypes: Potential Biomarkers for Diagnosis and Individualized Treatment for Subtypes of Autism Spectrum Disorder , 2019, Biological Psychiatry.

[11]  Mingbang Wang,et al.  Altered Urinary Amino Acids in Children With Autism Spectrum Disorders , 2019, Front. Cell. Neurosci..

[12]  Hala M. Sakhr,et al.  Possible Metabolic Alterations among Autistic Male Children: Clinical and Biochemical Approaches , 2019, Journal of Molecular Neuroscience.

[13]  G. Esposito,et al.  A systematic review of gut-immune-brain mechanisms in Autism Spectrum Disorder. , 2018, Developmental psychobiology.

[14]  X. Zou,et al.  Acyl-carnitine, C5DC, and C26 as potential biomarkers for diagnosis of autism spectrum disorder in children , 2018, Psychiatry Research.

[15]  T. R. Licht,et al.  Microbial tryptophan catabolites in health and disease , 2018, Nature Communications.

[16]  J. Mandel,et al.  Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder , 2018, Biological Psychiatry.

[17]  B. de Las Rivas,et al.  Ethylphenol Formation by Lactobacillus plantarum: Identification of the Enzyme Involved in the Reduction of Vinylphenols , 2018, Applied and Environmental Microbiology.

[18]  E. Hsiao,et al.  The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet , 2018, Cell.

[19]  K. Delucchi,et al.  Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli , 2018, Molecular Autism.

[20]  J. German,et al.  Dietary Considerations in Autism Spectrum Disorders: The Potential Role of Protein Digestion and Microbial Putrefaction in the Gut-Brain Axis , 2018, Front. Nutr..

[21]  P. Arguin,et al.  Malaria Surveillance — United States, 2015 , 2018, Morbidity and mortality weekly report. Surveillance summaries.

[22]  I. Hertz-Picciotto,et al.  Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms , 2018, Brain, Behavior, and Immunity.

[23]  J. Jodynis-Liebert,et al.  Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies , 2018, Nutrients.

[24]  Z. Warren,et al.  Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. , 2014, Morbidity and mortality weekly report. Surveillance summaries.

[25]  P. Vourc'h,et al.  Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population , 2018, Journal of pharmaceutical and biomedical analysis.

[26]  N. Pons,et al.  Indole, a Signaling Molecule Produced by the Gut Microbiota, Negatively Impacts Emotional Behaviors in Rats , 2018, Front. Neurosci..

[27]  Brittany D. Needham,et al.  Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder , 2018, Developmental neurobiology.

[28]  D. Hasselquist,et al.  No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird , 2018, Nature Communications.

[29]  Dae-Wook Kang,et al.  Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. , 2018, Anaerobe.

[30]  S. Schirmeier,et al.  Metabolite transport across the mammalian and insect brain diffusion barriers , 2017, Neurobiology of Disease.

[31]  T. Dinan,et al.  Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism , 2017, EBioMedicine.

[32]  E. Hsiao,et al.  The Microbiome and Host Behavior. , 2017, Annual review of neuroscience.

[33]  L. Atzori,et al.  The urinary 1H‐NMR metabolomics profile of an italian autistic children population and their unaffected siblings , 2017, Autism research : official journal of the International Society for Autism Research.

[34]  R. Levy,et al.  Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms , 2017, Oxidative medicine and cellular longevity.

[35]  T. Bourgeron,et al.  The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper , 2017, Autism research : official journal of the International Society for Autism Research.

[36]  S. Masino,et al.  Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches , 2017, Front. Mol. Neurosci..

[37]  Rob Knight,et al.  Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease , 2016, Cell.

[38]  L. Zolla,et al.  Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism , 2016, Molecular Autism.

[39]  Daniel H. Geschwind,et al.  The Central Nervous System and the Gut Microbiome , 2016, Cell.

[40]  Abigail Dickinson,et al.  Measuring neural excitation and inhibition in autism: Different approaches, different findings and different interpretations , 2016, Brain Research.

[41]  G. Baker,et al.  Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature , 2016, Amino Acids.

[42]  E. Hollander,et al.  Neurodevelopmental Disorders (ASD and ADHD): DSM-5, ICD-10, and ICD-11 , 2016, CNS Spectrums.

[43]  C. Andres,et al.  Metabolomics Study of Urine in Autism Spectrum Disorders Using a Multiplatform Analytical Methodology. , 2015, Journal of proteome research.

[44]  Sonia González,et al.  The relationship between phenolic compounds from diet and microbiota: impact on human health. , 2015, Food & function.

[45]  John F. Cryan,et al.  Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour , 2015, Brain, Behavior, and Immunity.

[46]  G. Pasinetti,et al.  Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization. , 2015, Molecular nutrition & food research.

[47]  D. Macfabe.  Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders , 2015, Microbial ecology in health and disease.

[48]  P. Sroka,et al.  Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review , 2015, European Journal of Nutrition.

[49]  L. Al-Ayadhi,et al.  Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations , 2015, Behavioral and Brain Functions.

[50]  L. Al-Ayadhi,et al.  Reduced levels of plasma polyunsaturated fatty acids and serum carnitine in autistic children: relation to gastrointestinal manifestations , 2015, Behavioral and Brain Functions.

[51]  D. Amaral,et al.  Metabolomics as a Tool for Discovery of Biomarkers of Autism Spectrum Disorder in the Blood Plasma of Children , 2014, PloS one.

[52]  L. Barberini,et al.  The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings , 2014, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[53]  M. Markuszewski,et al.  Identification of organic acids as potential biomarkers in the urine of autistic children using gas chromatography/mass spectrometry. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[54]  P. Hof,et al.  Metabolic costs and evolutionary implications of human brain development , 2014, Proceedings of the National Academy of Sciences.

[55]  C. Barthélémy,et al.  Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study , 2014, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[56]  B. Veeresh,et al.  Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice , 2014, Behavioural Brain Research.

[57]  S Baron-Cohen,et al.  Elevated fetal steroidogenic activity in autism , 2014, Molecular Psychiatry.

[58]  C. Andres,et al.  Combined 1H-NMR and 1H-13C HSQC-NMR to improve urinary screening in autism spectrum disorders. , 2014, The Analyst.

[59]  R. Naviaux,et al.  Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy , 2014, Translational Psychiatry.

[60]  F. Boscaino,et al.  Use of solid-phase microextraction coupled to gas chromatography–mass spectrometry for determination of urinary volatile organic compounds in autistic children compared with healthy controls , 2014, Analytical and Bioanalytical Chemistry.

[61]  M. Lobel,et al.  Low maternal progesterone may contribute to both obstetrical complications and autism. , 2014, Medical hypotheses.

[62]  J. Petrosino,et al.  Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders , 2013, Cell.

[63]  N. Rajesh,et al.  Maternal hormonal interventions as a risk factor for Autism Spectrum Disorder: An epidemiological assessment from India , 2013, Journal of Biosciences.

[64]  Marco Gobbetti,et al.  Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified , 2013, PloS one.

[65]  C. Barthélémy,et al.  1H-13C NMR-based urine metabolic profiling in autism spectrum disorders. , 2013, Talanta.

[66]  H. Yamasue,et al.  Altered Metabolites in the Plasma of Autism Spectrum Disorder: A Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study , 2013, PloS one.

[67]  P. Bieńkowski,et al.  Marked elevation of adrenal steroids, especially androgens, in saliva of prepubertal autistic children , 2013, European Child & Adolescent Psychiatry.

[68]  A. Legido,et al.  Mitochondrial dysfunction in autism. , 2013, Seminars in pediatric neurology.

[69]  C. Barthélémy,et al.  GC-MS-based urine metabolic profiling of autism spectrum disorders , 2013, Analytical and Bioanalytical Chemistry.

[70]  R. Frye,et al.  Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder , 2013, Translational Psychiatry.

[71]  S. Baron-Cohen,et al.  Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age , 2012, Molecular Autism.

[72]  A. El-Ansary,et al.  Lipid mediators in plasma of autism spectrum disorders , 2012, Lipids in Health and Disease.

[73]  H. Ripps,et al.  Review: Taurine: A “very essential” amino acid , 2012, Molecular vision.

[74]  Lining Guo,et al.  Metabolic perturbance in autism spectrum disorders: a metabolomics study. , 2012, Journal of proteome research.

[75]  M. Angley,et al.  Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in Children with Autism Spectrum Disorder , 2012, Digestive Diseases and Sciences.

[76]  Y. S. Kim,et al.  Global Prevalence of Autism and Other Pervasive Developmental Disorders , 2012, Autism research : official journal of the International Society for Autism Research.

[77]  C. Huttenhower,et al.  Metagenomic biomarker discovery and explanation , 2011, Genome Biology.

[78]  A. El-Ansary,et al.  Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia , 2011, Lipids in Health and Disease.

[79]  F. Muratori,et al.  Urinary p-cresol is elevated in small children with severe autism spectrum disorder , 2011, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[80]  James B. Adams,et al.  Gastrointestinal flora and gastrointestinal status in children with autism -- comparisons to typical children and correlation with autism severity , 2011, BMC gastroenterology.

[81]  J. Foster,et al.  Reduced anxiety‐like behavior and central neurochemical change in germ‐free mice , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[82]  D. Rossignol,et al.  Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis , 2011, Molecular Psychiatry.

[83]  H. Patisaul,et al.  The pros and cons of phytoestrogens , 2010, Frontiers in Neuroendocrinology.

[84]  J. Virués-Ortega,et al.  Applied behavior analytic intervention for autism in early childhood: meta-analysis, meta-regression and dose-response meta-analysis of multiple outcomes. , 2010, Clinical psychology review.

[85]  John C. Lindon,et al.  Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. , 2010, Journal of proteome research.

[86]  L. Bandini,et al.  Food selectivity and sensory sensitivity in children with autism spectrum disorders. , 2010, Journal of the American Dietetic Association.

[87]  Amy L. Donaldson,et al.  Randomized, Controlled Trial of an Intervention for Toddlers With Autism: The Early Start Denver Model , 2010, Pediatrics.

[88]  Chia-Yu Chang,et al.  Essential fatty acids and human brain. , 2009, Acta neurologica Taiwanica.

[89]  Doug Heath,et al.  Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism. , 2009, Prostaglandins, leukotrienes, and essential fatty acids.

[90]  R. Dantzer,et al.  Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice , 2009, Molecular Psychiatry.

[91]  Irva Hertz-Picciotto,et al.  The CHARGE Study: An Epidemiologic Investigation of Genetic and Environmental Factors Contributing to Autism , 2006, Environmental health perspectives.

[92]  David W Gaylor,et al.  Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. , 2004, The American journal of clinical nutrition.

[93]  Leo Breiman,et al.  Random Forests , 2001, Machine Learning.

[94]  D. Drossman,et al.  The functional gastrointestinal disorders and the Rome III process. , 1999, Gastroenterology.

[95]  J. Lombard.  Autism: a mitochondrial disorder? , 1998, Medical hypotheses.

[96]  W. Shaw,et al.  Increased urinary excretion of analogs of Krebs cycle metabolites and arabinose in two brothers with autistic features. , 1995, Clinical chemistry.

[97]  J. Blass,et al.  Autism and lactic acidosis , 1985, Journal of autism and developmental disorders.

[98]  A. Lis,et al.  Profiles of ultraviolet-absorbing components of urine from autistic children, as obtained by high-resolution ion-exchange chromatography. , 1976, Clinical chemistry.

[99]  J. O'brien,et al.  Lipid composition of the normal human brain: gray matter, white matter, and myelin. , 1965, Journal of lipid research.

[100]  W. J. Johannsen,et al.  A Re‐examination of the Hippuric Acid‐‐Anxiety Relationship , 1962, Psychosomatic medicine.

[101]  T. Grace,et al.  Role of the Gut Microbiome in Autism Spectrum Disorders. , 2019, Advances in experimental medicine and biology.

[102]  J. Willing,et al.  Exposure to the Synthetic Progestin, 17α-Hydroxyprogesterone Caproate During Development Impairs Cognitive Flexibility in Adulthood. , 2016, Endocrinology.

[103]  Changhao Sun,et al.  Potential serum biomarkers from a metabolomics study of autism. , 2016, Journal of psychiatry & neuroscience : JPN.

[104]  Janet K. Kern,et al.  An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders. , 2012, Acta neurobiologiae experimentalis.

[105]  L. Kanner.  Autistic disturbances of affective contact. , 1968, Acta paedopsychiatrica.