Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.

[1]  W. Helfrich,et al.  Therapeutic potential of Galectin‐9 in human disease , 2013, Medicinal research reviews.

[2]  L. Kane,et al.  Galectin-9 regulates T helper cell function independently of Tim-3. , 2011, Glycobiology.

[3]  T. Niki,et al.  Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages. , 2011, American journal of respiratory and critical care medicine.

[4]  Ke Wu,et al.  IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer , 2011, The Journal of Immunology.

[5]  坂井 利規 Galectin-9 ameliorates acute GVH disease through the induction of T-cell apoptosis , 2011 .

[6]  V. Kuchroo,et al.  TIM-3 and its regulatory role in immune responses. , 2011, Current topics in microbiology and immunology.

[7]  V. Kuchroo,et al.  Tim3 binding to galectin-9 stimulates antimicrobial immunity , 2010, The Journal of experimental medicine.

[8]  David H. Lee,et al.  Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells , 2010, The Journal of Immunology.

[9]  A. Yamauchi,et al.  Galectin‐9 expands immunosuppressive macrophages to ameliorate T‐cell‐mediated lung inflammation , 2010, European journal of immunology.

[10]  G. Rabinovich,et al.  Galectins: regulators of acute and chronic inflammation , 2010, Annals of the New York Academy of Sciences.

[11]  T. Niki,et al.  Galectin-9 Significantly Prolongs the Survival of Fully Mismatched Cardiac Allografts in Mice , 2009, Transplantation.

[12]  T. Niki,et al.  Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation , 2009, The Journal of Biological Chemistry.

[13]  D. Littman,et al.  Identification of IL-17-producing FOXP3+ regulatory T cells in humans , 2009, Proceedings of the National Academy of Sciences.

[14]  T. Niki,et al.  Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice. , 2009, Clinical immunology.

[15]  A. Weinmann,et al.  Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T‐box, GATA and ROR families , 2009, Immunology.

[16]  T. Niki,et al.  Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions1 , 2008, The Journal of Immunology.

[17]  T. Niki,et al.  Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices. , 2008, Glycobiology.

[18]  T. Niki,et al.  Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. , 2008, Clinical immunology.

[19]  David E. Anderson,et al.  Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells , 2007, Science.

[20]  A. Yamauchi,et al.  Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a mirine model of allergic asthma , 2007, American journal of respiratory and critical care medicine.

[21]  A. Yamauchi,et al.  Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. , 2007, Clinical immunology.

[22]  Terry B. Strom,et al.  IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells , 2007, Nature.

[23]  D. Levy,et al.  176 IL-6 Programs TH-17 Cell Differentiation by Promoting the Sequential Engagement of the IL-21 and IL-23 Pathways , 2007 .

[24]  A. D. Panopoulos,et al.  112 Essential Autocrine Regulation by IL-21 in the Generation of Inflammatory T Cells , 2007 .

[25]  S. Galli,et al.  Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL‐17 , 2007, Journal of leukocyte biology.

[26]  L. Hennighausen,et al.  Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. , 2007, Immunity.

[27]  A. Yamauchi,et al.  Characterization of galectin-9-induced death of Jurkat T cells. , 2006, Journal of biochemistry.

[28]  J. Ritz,et al.  IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. , 2006, Blood.

[29]  V. Kuchroo,et al.  The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity , 2005, Nature Immunology.

[30]  Ying Wang,et al.  A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 , 2005, Nature Immunology.

[31]  A. Yamauchi,et al.  Galectin-9 Induces Maturation of Human Monocyte-Derived Dendritic Cells , 2005, The Journal of Immunology.

[32]  M. Hirashima,et al.  Development of highly stable galectins: Truncation of the linker peptide confers protease‐resistance on tandem‐repeat type galectins , 2005, FEBS letters.

[33]  M. J. Abedin,et al.  Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway1 , 2003, The Journal of Immunology.

[34]  M. Hirashima,et al.  Human Ecalectin, a Variant of Human Galectin-9, Is a Novel Eosinophil Chemoattractant Produced by T Lymphocytes* , 1998, The Journal of Biological Chemistry.

[35]  Y. Kanwar,et al.  Identification and Characterization of Galectin-9, a Novel β-Galactoside-binding Mammalian Lectin* , 1997, The Journal of Biological Chemistry.