Mitochondrial transcription factor A (TFAM): one actor for different roles

[1]  Y. Yoo,et al.  Mitochondrial genome-maintaining activity of mouse mitochondrial transcription factor A and its transcript isoform in Saccharomyces cerevisiae. , 2011, Gene.

[2]  G. Shadel,et al.  The core human mitochondrial transcription initiation complex , 2011, Transcription.

[3]  H. Yonekawa,et al.  Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system. , 2010, Biochemical and biophysical research communications.

[4]  Yuichi Matsushima,et al.  Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM) , 2010, Proceedings of the National Academy of Sciences.

[5]  V. Bohr,et al.  The mitochondrial transcription factor A functions in mitochondrial base excision repair. , 2010, DNA repair.

[6]  S. Kuroda,et al.  Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice , 2010, Neuropathology : official journal of the Japanese Society of Neuropathology.

[7]  Hiroyuki Tsutsui,et al.  High mitochondrial DNA copy number has detrimental effects in mice. , 2010, Human molecular genetics.

[8]  C. Cameron,et al.  Core human mitochondrial transcription apparatus is a regulated two-component system in vitro , 2010, Proceedings of the National Academy of Sciences.

[9]  C. Gustafsson,et al.  Human Mitochondrial Transcription Revisited , 2010, The Journal of Biological Chemistry.

[10]  D. Temiakov,et al.  TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase , 2009, Cell.

[11]  A. Fersht,et al.  Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53 , 2009, Nucleic acids research.

[12]  Justin L Cotney,et al.  Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness. , 2009, Human molecular genetics.

[13]  I. Holt,et al.  Clinical and molecular aspects of diseases of mitochondrial DNA instability. , 2009, Chang Gung medical journal.

[14]  Yonghong Shi,et al.  Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. , 2009, Cell metabolism.

[15]  E. Shoubridge,et al.  The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes , 2008, Nature Genetics.

[16]  H. Shimokawa,et al.  Spontaneous myocardial infarction and nitric oxide synthase. , 2008, Trends in cardiovascular medicine.

[17]  C. Gustafsson,et al.  Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro , 2008, Proceedings of the National Academy of Sciences.

[18]  R. Scarpulla.  Transcriptional paradigms in mammalian mitochondrial biogenesis and function. , 2008, Physiological reviews.

[19]  D. Rousseau,et al.  The Layered Structure of Human Mitochondrial DNA Nucleoids* , 2008, Journal of Biological Chemistry.

[20]  E. Shoubridge,et al.  The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. , 2007, Molecular biology of the cell.

[21]  C. Gustafsson,et al.  DNA replication and transcription in mammalian mitochondria. , 2007, Annual review of biochemistry.

[22]  C. Newlon,et al.  Roles for the Human ATP-dependent Lon Protease in Mitochondrial DNA Maintenance* , 2007, Journal of Biological Chemistry.

[23]  Justin L Cotney,et al.  Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression , 2007, Nucleic acids research.

[24]  N. Hamasaki,et al.  The C-terminal tail of mitochondrial transcription factor a markedly strengthens its general binding to DNA. , 2007, Journal of biochemistry.

[25]  A. Reyes,et al.  The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization , 2007, The Journal of cell biology.

[26]  D. A. Clayton,et al.  Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. , 2006, Molecular cell.

[27]  R. Lightowlers,et al.  Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene , 2006, Nucleic acids research.

[28]  H. Jacobs,et al.  Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells , 2006, Nucleic acids research.

[29]  Justin L Cotney,et al.  Evidence for an Early Gene Duplication Event in the Evolution of the Mitochondrial Transcription Factor B Family and Maintenance of rRNA Methyltransferase Activity in Human mtTFB1 and mtTFB2 , 2006, Journal of Molecular Evolution.

[30]  D. Bogenhagen,et al.  Human Mitochondrial DNA Nucleoids Are Linked to Protein Folding Machinery and Metabolic Enzymes at the Mitochondrial Inner Membrane* , 2006, Journal of Biological Chemistry.

[31]  H. Tsutsui.  Mitochondrial oxidative stress and heart failure. , 2006, Internal medicine.

[32]  T. Prolla,et al.  Mitochondrial DNA mutations and apoptosis in mammalian aging. , 2006, Cancer research.

[33]  Laura C. Greaves,et al.  Mitochondrial DNA mutations in human disease , 2006, IUBMB life.

[34]  R. Wiesner,et al.  Mitochondrial DNA damage and the aging process–facts and imaginations , 2006, Free radical research.

[35]  J. Griffith,et al.  Termination Factor-Mediated DNA Loop between Termination and Initiation Sites Drives Mitochondrial rRNA Synthesis , 2005, Cell.

[36]  R. Reeves,et al.  Inhibition of Nucleotide Excision Repair by High Mobility Group Protein HMGA1* , 2005, Journal of Biological Chemistry.

[37]  K. Sunagawa,et al.  Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction , 2005, Circulation.

[38]  T. D. Pugh,et al.  Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging , 2005, Science.

[39]  N. Hamasaki,et al.  Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA , 2005, Annals of the New York Academy of Sciences.

[40]  Robert W. Taylor,et al.  Mitochondrial DNA mutations in human disease , 2005, Nature Reviews Genetics.

[41]  Y. Matsushima,et al.  Drosophila Mitochondrial Transcription Factor B1 Modulates Mitochondrial Translation but Not Transcription or DNA Copy Number in Schneider Cells* , 2005, Journal of Biological Chemistry.

[42]  Tomaso Poggio,et al.  Identification and analysis of alternative splicing events conserved in human and mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  B. Kaufman,et al.  Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance , 2005, Science.

[44]  C. Gustafsson,et al.  The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells , 2004, The EMBO journal.

[45]  N. Hamasaki,et al.  Architectural Role of Mitochondrial Transcription Factor A in Maintenance of Human Mitochondrial DNA , 2004, Molecular and Cellular Biology.

[46]  Y. Matsushima,et al.  Drosophila Mitochondrial Transcription Factor B2 Regulates Mitochondrial DNA Copy Number and Transcription in Schneider Cells* , 2004, Journal of Biological Chemistry.

[47]  P. Frachon,et al.  Organization and dynamics of human mitochondrial DNA , 2004, Journal of Cell Science.

[48]  Hiroshi Kimura,et al.  The functional organization of mitochondrial genomes in human cells , 2004, BMC Biology.

[49]  P. Rustin,et al.  Mitochondrial transcription factor A regulates mtDNA copy number in mammals. , 2004, Human molecular genetics.

[50]  Tong Liu,et al.  DNA and RNA Binding by the Mitochondrial Lon Protease Is Regulated by Nucleotide and Protein Substrate* , 2004, Journal of Biological Chemistry.

[51]  H. Itoh,et al.  P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. , 2003, Cancer research.

[52]  A. M. van der Bliek,et al.  Composition and dynamics of human mitochondrial nucleoids. , 2003, Molecular biology of the cell.

[53]  N. Hamasaki,et al.  Human mitochondrial DNA is packaged with TFAM. , 2003, Nucleic acids research.

[54]  Irene Lee,et al.  The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals. , 2003, Gene.

[55]  N. Larsson,et al.  Manipulation of mitochondrial DNA gene expression in the mouse. , 2002, Biochimica et biophysica acta.

[56]  H. Uramoto,et al.  Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA. , 2002, Biochemical and biophysical research communications.

[57]  C. Gustafsson,et al.  Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA , 2002, Nature Genetics.

[58]  A. Reyes,et al.  Human mitochondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes. , 2002, Gene.

[59]  N. Hamasaki,et al.  Regulation of mitochondrial D‐loops by transcription factor A and single‐stranded DNA‐binding protein , 2002, EMBO reports.

[60]  Ellen L. Shen,et al.  Developmentally-regulated packaging of mitochondrial DNA by the HMG-box protein mtTFA during Xenopus oogenesis , 2001, Nucleic Acids Res..

[61]  V. Pesce,et al.  Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle. , 2001, Free radical biology & medicine.

[62]  C. Moraes.  What regulates mitochondrial DNA copy number in animal cells? , 2001, Trends in genetics : TIG.

[63]  C. Graff,et al.  Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes , 2000, Nature Genetics.

[64]  G. Gadaleta,et al.  The 25 kDa protein recognizing the rat curved region upstream of the origin of the L‐strand replication is the rat homologue of the human mitochondrial transcription factor A , 1999, FEBS letters.

[65]  P. Mecocci,et al.  Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[66]  D. Clayton,et al.  Initiation of Mitochondrial DNA Replication by Transcription and R-loop Processing* , 1998, The Journal of Biological Chemistry.

[67]  G. Barsh,et al.  Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice , 1998, Nature Genetics.

[68]  G. Barsh,et al.  Structure and chromosomal localization of the mouse mitochondrial transcription factor a gene (Tfam) , 1997, Mammalian Genome.

[69]  G. Barsh,et al.  Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans. , 1997, Human molecular genetics.

[70]  D. A. Clayton,et al.  A single mouse gene encodes the mitochondrial transcription factor A and a testis–specific nuclear HMG-box protein , 1996, Nature Genetics.

[71]  I. Antoshechkin,et al.  Distinct roles for two purified factors in transcription of Xenopus mitochondrial DNA , 1995, Molecular and cellular biology.

[72]  D. A. Clayton,et al.  Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. , 1995, Journal of molecular biology.

[73]  W. Hauswirth,et al.  In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication , 1994, Molecular and cellular biology.

[74]  S. Lippard,et al.  HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[75]  Y. Kagawa,et al.  Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing. , 1993, Biochemical and biophysical research communications.

[76]  T. Megraw,et al.  Functional complementarity between the HMG1-like yeast mitochondrial histone HM and the bacterial histone-like protein HU. , 1993, The Journal of biological chemistry.

[77]  D. A. Clayton,et al.  A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro , 1993, Molecular and cellular biology.

[78]  F. Foury,et al.  A single‐stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. , 1992, The EMBO journal.

[79]  M. Parisi,et al.  DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. , 1992, The Journal of biological chemistry.

[80]  J. Diffley,et al.  A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[81]  V. Tiranti,et al.  A full-length cDNA encoding a mitochondrial DNA-specific single-stranded DNA binding protein from Xenopus laevis. , 1991, Nucleic acids research.

[82]  D. A. Clayton,et al.  Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. , 1991, Science.

[83]  M. Parisi,et al.  Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. , 1989, Genes & development.

[84]  M. King,et al.  Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. , 1989, Science.

[85]  D. A. Clayton,et al.  Purification and characterization of human mitochondrial transcription factor 1 , 1988, Molecular and cellular biology.

[86]  R. Fisher,et al.  A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. , 1985, The Journal of biological chemistry.

[87]  P. Pavco,et al.  The rat liver mitochondrial DNA-protein complex: displaced single strands of replicative intermediates are protein coated , 1985, The Journal of cell biology.

[88]  M. Rabinowitz,et al.  Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[89]  D. A. Clayton,et al.  Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle , 1977, Cell.

[90]  R. Wiesner,et al.  Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. , 2004, Nucleic acids research.

[91]  Marty C. Brandon,et al.  a human mitochondrial , 2004 .

[92]  G. Shadel,et al.  Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop , 2003, Nature Genetics.

[93]  V. Bohr,et al.  The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair. , 2002, International review of neurobiology.

[94]  Jens C. Brüning,et al.  Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression , 1999, Nature Genetics.

[95]  G. Shadel,et al.  Mitochondrial DNA maintenance in vertebrates. , 1997, Annual review of biochemistry.

[96]  P. Pavco,et al.  The Rat Liver Mitochondrial Dna-protein Complex: Displaced Single Strands of Replicative Intermediates Are Protein Coated , 1981 .