Effect of domoic acid on metabolism of 5-hydroxytryptamine in rat brain

Domoic acid (Dom) is a neurotoxic secondary amino acid that interacts with the glutamate receptors, producing neurological problems. In the present work, we study the effects of Dom on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete rat brain regions. The effects of Dom on the brain metabolism of serotonin are also discussed in this paper. Dom stimulates the rat brain serotoninergic system, increasing differentially the synthesis and the catabolism of 5-HT and the elimination of 5-HIAA.

[1]  R. Zatorre,et al.  Neurological sequelae of domoic acid intoxication. , 1990, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada.

[2]  M. Youdim,et al.  Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity? , 1985, European journal of pharmacology.

[3]  C. Montigny,et al.  Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus. , 1989, Canadian journal of physiology and pharmacology.

[4]  I. Kilpatrick,et al.  A Semiautomated Analysis Method for Catecholamines, Indoleamines, and Some Prominent Metabolites in Microdissected Regions of the Nervous System: An Isocratic HPLC Technique Employing Coulometric Detection and Minimal Sample Preparation , 1986, Journal of neurochemistry.

[5]  G. Debonnel,et al.  Reduced neuroexcitatory effect of domoic acid following mossy fiber denervation of the rat dorsal hippocampus: further evidence that toxicity of domoic acid involves kainate receptor activation. , 1989, Canadian journal of physiology and pharmacology.

[6]  D. Bender.  Regulation of 5-hydroxytryptamine Synthesis , 1978, Proceedings of the Nutrition Society.

[7]  E. Nera,et al.  The toxicology of domoic acid administered systemically to rodents and primates. , 1990, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada.

[8]  T. Kosatsky,et al.  Amnesic shellfish poisoning: a new clinical syndrome due to domoic acid. , 1990, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada.

[9]  T. Tozer,et al.  In vivo measurement of brain serotonin turnover. , 1968, Advances in pharmacology.

[10]  R. H. Evans,et al.  Domoic and quisqualic acids as potent amino acid excitants of frog and rat spinal neurones , 1975, Nature.

[11]  S. Bates,et al.  TRACE·DETERMINATION OF DOMOIC ACID IN SEAWATER AND PHYTOPLANKTON BY HIGH­ PERFORMANCE LIQUID CHROMATOGRAPHY OF THE FLUORENYLMETHOXYCARBONYL (FMOC) DERIVATIVE* , 1990 .