Development of a general method for obtaining the geometry of microfluidic networks

In the present study, a general method for geometry of fluidic networks is developed with emphasis on pressure-driven flows in the microfluidic applications. The design method is based on general features of network's geometry such as cross-sectional area and length of channels. Also, the method is applicable to various cross-sectional shapes such as circular, rectangular, triangular, and trapezoidal cross sections. Using constructal theory, the flow resistance, energy loss and performance of the network are optimized. Also, by this method, practical design strategies for the fabrication of microfluidic networks can be improved. The design method enables rapid prediction of fluid flow in the complex network of channels and is very useful for improving proper miniaturization and integration of microfluidic networks. Minimization of flow resistance of the network of channels leads to universal constants for consecutive cross-sectional areas and lengths. For a Y-shaped network, the optimal ratios of consecut...

[1]  Bingcheng Lin,et al.  Droplet-based microfluidic system for individual Caenorhabditis elegans assay. , 2008, Lab on a chip.

[2]  Andreas Manz,et al.  Micro total analysis systems: latest achievements. , 2008, Analytical chemistry.

[3]  B L Langille,et al.  Arterial bifurcations in the cardiovascular system of a rat , 1983, The Journal of general physiology.

[4]  Shoji Takeuchi,et al.  A trap-and-release integrated microfluidic system for dynamic microarray applications , 2007, Proceedings of the National Academy of Sciences.

[5]  Chong H. Ahn,et al.  Miniaturization of pinch-type valves and pumps for practical micro total analysis system integration , 2005 .

[6]  B. Kirby Micro- and nanoscale fluid mechanics : transport in microfluidic devices , 2010 .

[7]  Andreas Manz,et al.  Latest developments in micro total analysis systems. , 2010, Analytical chemistry.

[8]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[9]  N. Mortensen,et al.  Reexamination of Hagen-Poiseuille flow: shape dependence of the hydraulic resistance in microchannels. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[10]  Dongshin Kim,et al.  A method for dynamic system characterization using hydraulic series resistance. , 2006, Lab on a chip.

[11]  François Rousset,et al.  Theoretical Biology and Medical Modelling Extension of Murray's Law Using a Non-newtonian Model of Blood Flow , 2022 .

[12]  A. Bejan,et al.  The constructal law and the evolution of design in nature. , 2011, Physics of life reviews.

[13]  A. Manz,et al.  Micro total analysis systems. Latest advancements and trends. , 2006, Analytical chemistry.

[14]  Shuichi Takayama,et al.  Fabrication of microfluidic mixers and artificial vasculatures using a high-brightness diode-pumped Nd:YAG laser direct write method. , 2003, Lab on a chip.

[15]  David R. Emerson,et al.  Optimal design of microfluidic networks using biologically inspired principles , 2008 .

[16]  J. Kang,et al.  A serial dilution microfluidic device using a ladder network generating logarithmic or linear concentrations. , 2008, Lab on a chip.

[17]  C D Murray,et al.  The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. , 1926, Proceedings of the National Academy of Sciences of the United States of America.

[18]  T F Sherman,et al.  On connecting large vessels to small. The meaning of Murray's law , 1981, The Journal of general physiology.

[19]  J. Sperry,et al.  Murray's law, the 'Yarrum' optimum, and the hydraulic architecture of compound leaves. , 2009, The New phytologist.

[20]  Yanwei Jia,et al.  Simple, robust storage of drops and fluids in a microfluidic device. , 2009, Lab on a chip.

[21]  S. Vanapalli,et al.  Behavior of a train of droplets in a fluidic network with hydrodynamic traps. , 2010, Biomicrofluidics.

[22]  R S Trask,et al.  Minimum mass vascular networks in multifunctional materials , 2008, Journal of The Royal Society Interface.

[23]  P. Silberzan,et al.  Microfluidics for biotechnology , 2005 .

[24]  A. Valero,et al.  Optimization of microfluidic single cell trapping for long-term on-chip culture. , 2010, Lab on a chip.

[25]  H. Morgan,et al.  Integrated systems for rapid point of care (PoC) blood cell analysis. , 2011, Lab on a chip.

[26]  J. Sperry,et al.  Water transport in plants obeys Murray's law , 2003, Nature.

[27]  Adrian Bejan,et al.  The constructal unification of biological and geophysical design. , 2009, Physics of life reviews.

[28]  Jung Yeop Lee,et al.  Murray’s law and the bifurcation angle in the arterial micro-circulation system and their application to the design of microfluidics , 2009 .