Synthesis of Nanogels via Cell Membrane-Templated Polymerization.

The synthesis of biomimetic hydrogel nanoparticles coated with a natural cell membrane is described. Compared to the existing strategy of wrapping cell membranes onto pre-formed nanoparticle substrates, this new approach forms the cell membrane-derived vesicles first, followed by growing nanoparticle cores in situ. It adds significant controllability over the nanoparticle properties and opens unique opportunities for a broad range of biomedical applications.

[1]  Liangfang Zhang,et al.  Engineering red‐blood‐cell‐membrane–coated nanoparticles for broad biomedical applications , 2015 .

[2]  Peter Y. Li,et al.  Structural elucidation of cell membrane-derived nanoparticles using molecular probes. , 2014, Journal of materials chemistry. B.

[3]  Feng Gao,et al.  Erythrocyte membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy. , 2014, ACS nano.

[4]  Sytze J Buwalda,et al.  Hydrogels in a historical perspective: from simple networks to smart materials. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Ronnie H. Fang,et al.  Clearance of pathological antibodies using biomimetic nanoparticles , 2014, Proceedings of the National Academy of Sciences.

[6]  Ronnie H. Fang,et al.  Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery , 2014, Nano letters.

[7]  David L. Marshall,et al.  Photodissociation of TEMPO-modified peptides: new approaches to radical-directed dissociation of biomolecules. , 2014, Physical chemistry chemical physics : PCCP.

[8]  K. Kiick,et al.  Multifunctional lipid-coated polymer nanogels crosslinked by photo-triggered Michael-type addition , 2014 .

[9]  Chaenyung Cha,et al.  25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine , 2014, Advanced materials.

[10]  Loai K. E. A. Abdelmohsen,et al.  Biocompatible macro-initiators controlling radical retention in microfluidic on-chip photo-polymerization of water-in-oil emulsions. , 2014, Chemical communications.

[11]  Ronnie H. Fang,et al.  Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles. , 2013, Nanoscale.

[12]  Ronnie H. Fang,et al.  Nanoparticle-detained toxins for safe and effective vaccination , 2013, Nature nanotechnology.

[13]  Ronnie H. Fang,et al.  Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes , 2013, Advanced materials.

[14]  Ronnie H. Fang,et al.  A biomimetic nanosponge that absorbs pore-forming toxins , 2013, Nature nanotechnology.

[15]  Ronnie H. Fang,et al.  'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach. , 2013, Nanoscale.

[16]  Richard A Flavell,et al.  Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. , 2012, Nature materials.

[17]  D. Seliktar Designing Cell-Compatible Hydrogels for Biomedical Applications , 2012, Science.

[18]  K. Akiyoshi,et al.  Self-assembled Nanogel Engineering for Advanced Biomedical Technology , 2012 .

[19]  K. Akiyoshi,et al.  Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[20]  Ronnie H. Fang,et al.  Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform , 2011, Proceedings of the National Academy of Sciences.

[21]  Robert Langer,et al.  Poly(ethylene glycol) with observable shedding. , 2010, Angewandte Chemie.

[22]  Kristi S Anseth,et al.  Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility. , 2009, Biomaterials.

[23]  Koen Raemdonck,et al.  Advanced nanogel engineering for drug delivery , 2009 .

[24]  M. Gaitan,et al.  Liposome-templated supramolecular assembly of responsive alginate nanogels. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[25]  K. Akiyoshi,et al.  Nanogel‐Templated Mineralization: Polymer‐Calcium Phosphate Hybrid Nanomaterials , 2006 .

[26]  M. Cowman,et al.  Poly(N-isopropylacrylamide-co-1-vinylimidazole) Hydrogel Nanoparticles Prepared and Hydrophobically Modified in Liposome Reactors: Atomic Force Microscopy and Dynamic Light Scattering Study , 2003 .

[27]  Marian Kaholek,et al.  UV-Induced Gelation on Nanometer Scale Using Liposome Reactor , 2002 .

[28]  C. Bolm,et al.  Silica-supported TEMPO catalysts: synthesis and application in the Anelli oxidation of alcohols. , 2001, The Journal of organic chemistry.

[29]  V. Lew,et al.  Mechanism of spontaneous inside-out vesiculation of red cell membranes , 1988, The Journal of cell biology.

[30]  R. Weinstein,et al.  Inside-Out Red Cell Membrane Vesicles: Preparation and Puirification , 1970, Science.

[31]  Anne L. van de Ven,et al.  Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. , 2013, Nature nanotechnology.

[32]  T. Imae,et al.  Nanogel formation consisting of DNA and poly(amido amine) dendrimer studied by static light scattering and atomic force microscopy. , 2004, Biomacromolecules.