SOME ASPECTS OF THE MODE OF ACTION OF POLYENE ANTIFUNGAL ANTIBIOTICS

Since the discovery of nystatin in 1951 by Hazen and Brown: a new class of antifungal agents has been described in recent years; most of these are products of variousStreptomycesfermentations. These agents, characterized by a chromophore group formed by conjugating double bonds, are grouped under the name of polyene antibiotics f9 they exhibit characteristic ultraviolet absorption spectra and are of low solubility in water, but dissolve more readily in aqueous solutions of the lower alcohols or pyridine. They inhibit the growth of a wide range of fungi, including yeasts and filamentous fungi, pathogenic or nonpathogenic, but are ineffective against bacteria, actinomycetes, and viruses or animal cells; they are not toxic when given by mouth, but show some toxic side effects, such as hyperthermia, when injected into animals and humans.13 f56

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