Generating different profiles of gradient concentrations inside a gel-filled chamber: design and simulation

[1]  Craig A Simmons,et al.  Macro- and microscale fluid flow systems for endothelial cell biology. , 2010, Lab on a chip.

[2]  J. Gurdon,et al.  Morphogen gradient interpretation , 2001, Nature.

[3]  A. Folch,et al.  A multi-purpose microfluidic perfusion system with combinatorial choice of inputs, mixtures, gradient patterns, and flow rates. , 2009, Lab on a chip.

[4]  Dayu Liu,et al.  Fabrication of a microfluidic chip containing dam, weirs and gradient generator for studying cellular response to chemical modulation , 2009 .

[5]  Chang Mo Hwang,et al.  Simultaneous generation of chemical concentration and mechanical shear stress gradients using microfluidic osmotic flow comparable to interstitial flow. , 2009, Lab on a chip.

[6]  Roger D Kamm,et al.  A high-throughput microfluidic assay to study neurite response to growth factor gradients. , 2011, Lab on a chip.

[7]  Taesung Kim,et al.  Diffusion-based and long-range concentration gradients of multiple chemicals for bacterial chemotaxis assays. , 2010, Analytical chemistry.

[8]  S. Quake,et al.  Microfluidics: Fluid physics at the nanoliter scale , 2005 .

[9]  Steffen Hardt,et al.  Microfluidic Technologies for Miniaturized Analysis Systems , 2007 .

[10]  Roger D Kamm,et al.  In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients. , 2011, Lab on a chip.

[11]  Qingming Luo,et al.  Microfluidic chip: next-generation platform for systems biology. , 2009, Analytica chimica acta.

[12]  Dayu Liu,et al.  Design of parallel microfluidic gradient-generating networks for studying cellular response to chemical stimuli , 2008 .

[13]  Ralph G Nuzzo,et al.  Guiding neuron development with planar surface gradients of substrate cues deposited using microfluidic devices. , 2010, Lab on a chip.

[14]  David J Beebe,et al.  A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. , 2008, Lab on a chip.

[15]  Mingming Wu,et al.  An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies , 2009, Biomedical microdevices.

[16]  Jian-Hua Wang,et al.  A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay. , 2011, Lab on a chip.

[17]  L. Lebrun,et al.  Diffusion of sucrose and dextran through agar gel membranes. , 1993, Enzyme and microbial technology.

[18]  Noo Li Jeon,et al.  Generation of stable complex gradients across two-dimensional surfaces and three-dimensional gels. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[19]  Jong-Hoon Kim,et al.  Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient , 2009, Stem cells.

[20]  N. Jeon,et al.  Biological applications of microfluidic gradient devices. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[21]  Lin‐Yue Lanry Yung,et al.  Controlled microscale diffusion gradients in quiescent extracellular fluid , 2010, Biomedical microdevices.

[22]  M. Maharbiz,et al.  Generating steep, shear-free gradients of small molecules for cell culture , 2009, Biomedical microdevices.

[23]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[24]  A. Folch,et al.  Biomolecular gradients in cell culture systems. , 2008, Lab on a chip.

[25]  Hongkai Wu,et al.  Generation of complex, static solution gradients in microfluidic channels. , 2006, Journal of the American Chemical Society.

[26]  Grace N Li,et al.  Multi-Molecular Gradients of Permissive and Inhibitory Cues Direct Neurite Outgrowth , 2008, Annals of Biomedical Engineering.

[27]  B. Chung,et al.  Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber , 2007, Biomedical microdevices.

[28]  G. Ming,et al.  A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. , 2008, Lab on a chip.

[29]  Albert Folch,et al.  A modular cell culture device for generating arrays of gradients using stacked microfluidic flows. , 2011, Biomicrofluidics.

[30]  Abbas Z. Kouzani,et al.  Gradient Generating Microfluidic Devices for Cell Cultivation , 2012 .

[31]  C. Cannizzaro,et al.  Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. , 2010, Lab on a chip.

[32]  James Briscoe,et al.  The interpretation of morphogen gradients , 2006, Development.

[33]  K. Jensen,et al.  Cells on chips , 2006, Nature.

[34]  M. Chudy,et al.  Evaluation of cytotoxic effect of 5-fluorouracil on human carcinoma cells in microfluidic system , 2011 .

[35]  Axel Scherer,et al.  Experimentally validated quantitative linear model for the device physics of elastomeric microfluidic valves. , 2007, Journal of applied physics.

[36]  Jessica Melin,et al.  Microfluidic large-scale integration: the evolution of design rules for biological automation. , 2007, Annual review of biophysics and biomolecular structure.

[37]  A. Folch,et al.  A neuron-benign microfluidic gradient generator for studying the growth of mammalian neurons towards axon guidance factors , 2009, TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference.

[38]  D. Beebe,et al.  Selective and tunable gradient device for cell culture and chemotaxis study. , 2009, Lab on a chip.

[39]  H. Stone,et al.  Microfluidics: Basic issues, applications, and challenges , 2001 .