LOW VITAMIN B6 LEVELS ARE ASSOCIATED WITH WHITE MATTER LESIONS IN ALZHEIMER'S DISEASE

To the Editor: Vitamin B6 is important in the reduction of a potentially toxic excess of homocysteine. Low levels of vitamin B6 are related to cognitive decline, but the underlying mechanism is not known. We hypothesized that vascular lesions in the brain may mediate this and studied the relation between vitamin B6 levels and the presence of white matter lesions (WMLs) on magnetic resonance imaging (MRI) in patients with Alzheimer’s disease (AD).

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