Evaluation of the sensitivity of red blood cell markers to detect photodynamic membrane damage

BACKGROUND: Photodynamic dyes have been used to investigate pathogen reduction methods in RBC suspen‐sions, but treatment with sensitizers and light can produce unwanted membrane damage during routine blood bank storage. This study compares the relative sensitivity of three assays for detecting RBC membrane damage.

[1]  A. Verhoeven,et al.  Composition of the additive solution affects red blood cell integrity after photodynamic treatment , 2003, Vox sanguinis.

[2]  S. Wagner,et al.  Quinacrine Enhances Vesicular Stomatitis Virus Inactivation and Diminishes Hemolysis of Dimethylmethylene Blue–phototreated Red Cells¶ , 2002, Photochemistry and photobiology.

[3]  J. Hess,et al.  Storage of red blood cells: new approaches. , 2002, Transfusion medicine reviews.

[4]  S. Wagner,et al.  Use of a flow‐cell system to investigate virucidal dimethylmethylene blue phototreatment in two RBC additive solutions , 2002, Transfusion.

[5]  W. Buurman,et al.  Prestorage leucocyte reduction of red cell components prevents release of bactericidal permeability increasing protein and defensins , 2002, Vox sanguinis.

[6]  H. Mohr Methylene blue and thionine in pathogen inactivation of plasma and platelet concentrates. , 2001, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[7]  G. Willems,et al.  Binding of annexin V to membrane products of lipid peroxidation. , 2001, Biochemistry.

[8]  D. Meruelo,et al.  Strategies for Evaluation of Enveloped Virus Inactivation in Red Cell Concentrates Using Hypericin , 2000, Photochemistry and photobiology.

[9]  G.,et al.  Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis , 2000 .

[10]  J. Bonnefoy,et al.  Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. , 1999, Cytometry.

[11]  L. Cincotta,et al.  Factors Affecting Virus Photoinactivation by a Series of Phenothiazine Dyes , 1998, Photochemistry and photobiology.

[12]  F. Kuypers,et al.  Oxidative damage does not alter membrane phospholipid asymmetry in human erythrocytes. , 1997, Biochemistry.

[13]  A. Moor,et al.  Shelf‐life of photodynamically sterilized red cell concentrates with various numbers of white cells , 1997, Transfusion.

[14]  C Haanen,et al.  A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. , 1995, Journal of immunological methods.

[15]  N. Geacintov,et al.  Virus inactivation in red cell concentrates by photosensitization with phthalocyanines: protection of red cells but not of vesicular stomatitis virus with a water‐soluble analogue of vitamin E , 1995, Transfusion.

[16]  C. Högman,et al.  Half‐Strength Citrate CPD Combined with a New Additive Solution for Improved Storage of Red Blood Cells Suitable for Clinical Use , 1993, Vox sanguinis.

[17]  R. Stromberg,et al.  Red cell alterations associated with virucidal methylene blue phototreatment , 1993, Transfusion.

[18]  N. Geacintov,et al.  Inactivation of viruses in red cell and platelet concentrates with aluminum phthalocyanine (AIPc) sulfonates. , 1992, Blood cells.

[19]  D. Gaffney,et al.  Evaluation of merocyanine 540-sensitized photoirradiation as a means to inactivate enveloped viruses in blood products. , 1990, The Journal of laboratory and clinical medicine.

[20]  J. Levy,et al.  Development of a model to demonstrate photosensitizer‐mediated viral inactivation in blood , 1990, Transfusion.

[21]  T. Dubbelman,et al.  Enhancement of transbilayer mobility of a membrane lipid probe accompanies formation of membrane leaks during photodynamic treatment of erythrocytes. , 1989, Biochimica et biophysica acta.

[22]  J. Pooler The kinetics of colloid osmotic hemolysis. I. Nystatin-induced lysis. , 1985, Biochimica et biophysica acta.

[23]  J. Pooler The kinetics of colloid osmotic hemolysis. II. Photohemolysis. , 1985, Biochimica et biophysica acta.

[24]  A. Girotti,et al.  Lysis of resealed erythrocyte ghosts by photoactivated tetrapyrroles: estimation of photolesion dimensions. , 1982, The International journal of biochemistry.

[25]  D. Vanderjagt,et al.  Use of tetramethylbenzidine in plasma hemoglobin assay. , 1977, Clinical chemistry.