Although the utilizing of renewable energy sources (RESs) in microgrid (MG) offers a recognized solution to meet the increasing demand, it’s performance depend on various meteorological factors of RESs. Again, the functioning of MGs is often affected with certain industrial load dynamics which allowing them to alter the operating region and tracking function of the MGs. The above-mentioned challenges motivate us to design the ancillary voltage control design for enabling the MGs to provide adaptive transient and tracking voltage responses over the changes of various factors like weather, consumer demand, and industrial loads. Firstly, we design an intelligent adaptive control (IAC) framework made by merging with proportional-integral (PI) regulator and artificial neural network (ANN) to sustain the regulated common bus voltage over the mentioned changes. The regulated bus voltage is forwarded to operate the industrial loads via the regulation of inverter-based secondary network (SN). A study on the variation of weather condition and consumer demand is done to show the efficacy of the IAC framework. Secondly, we propose a novel fixed control structure named model reference modified fractional-order PID (MR-F0PID) regulator to maintain the high tracking response of the MG via the control of inverter associated with the SNs. The tracking competency of this fixed control framework is analyzed over the running of a few industrial loads dynamics associated with single-phase inverter based SN and results are compared with the other related existing controllers. Moreover, a mathematical analysis for mapping the stable region is completed here to track down the closed-loop stability area. As a further study, the three-phase inverter based SN associated with several three-phase industrial load is also considered with the same DC bus and analyzed to observe the competency of the proposed fixed MR-FOPID control framework.