Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia

[1]  M. Frosch,et al.  Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain , 2019, Neuron.

[2]  Publisher'sNote , 2019, Management Accounting Research.

[3]  Alejandro F. Frangi,et al.  Quantitative histomorphometry of capillary microstructure in deep white matter , 2019, NeuroImage: Clinical.

[4]  R. Kalaria,et al.  White matter capillaries in vascular and neurodegenerative dementias , 2019, Acta Neuropathologica Communications.

[5]  Alejandro F Frangi,et al.  Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions , 2019, PloS one.

[6]  R. Carare,et al.  Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain , 2019, Front. Aging Neurosci..

[7]  Yao Yao Basement membrane and stroke , 2018, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  R. Milner,et al.  Chronic mild hypoxia increases expression of laminins 111 and 411 and the laminin receptor α6β1 integrin at the blood-brain barrier , 2018, Brain Research.

[9]  Roxana O. Carare,et al.  Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways , 2018, Acta Neuropathologica.

[10]  Seth Love,et al.  Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. , 2016, Clinical science.

[11]  R. Milner,et al.  Chronic mild hypoxia promotes profound vascular remodeling in spinal cord blood vessels, preferentially in white matter, via an α5β1 integrin-mediated mechanism , 2018, Angiogenesis.

[12]  Alexandra K. Diem,et al.  Arterial Pulsations cannot Drive Intramural Periarterial Drainage: Significance for Aβ Drainage , 2017, Front. Neurosci..

[13]  Alan J. Thomas,et al.  PARIETAL WHITE MATTER LESIONS IN ALZHEIMER’S DISEASE ARE ASSOCIATED WITH CORTICAL NEURODEGENERATIVE PATHOLOGY AND NOT WITH SMALL-VESSEL DISEASE , 2017, Alzheimer's & Dementia.

[14]  Alan J. Thomas,et al.  Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease , 2017, Acta Neuropathologica.

[15]  J. Frontera,et al.  Acute Cytotoxic and Vasogenic Edema after Subarachnoid Hemorrhage: A Quantitative MRI Study , 2017, American Journal of Neuroradiology.

[16]  B. Engelhardt,et al.  The movers and shapers in immune privilege of the CNS , 2017, Nature Immunology.

[17]  Kevin W. Eliceiri,et al.  ImageJ2: ImageJ for the next generation of scientific image data , 2017, BMC Bioinformatics.

[18]  J. Ghiso,et al.  In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein , 2016, Front. Aging Neurosci..

[19]  Britta Engelhardt,et al.  Vascular, glial, and lymphatic immune gateways of the central nervous system , 2016, Acta Neuropathologica.

[20]  J. Attems,et al.  Edinburgh Research Explorer Deposition of amyloid in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy , 2015 .

[21]  R. Carare,et al.  Vascular basement membranes as pathways for the passage of fluid into and out of the brain Journal Item , 2018 .

[22]  M. Nelson,et al.  Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain? , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[23]  N. Xu,et al.  MMP-2 Is Mainly Expressed in Arterioles and Contributes to Cerebral Vascular Remodeling Associated with TGF-β1 Signaling , 2016, Journal of Molecular Neuroscience.

[24]  N. Xu,et al.  MMP-2 Is Mainly Expressed in Arterioles and Contributes to Cerebral Vascular Remodeling Associated with TGF-β1 Signaling , 2015, Journal of Molecular Neuroscience.

[25]  J. Hardy,et al.  Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau? , 2015, Acta Neuropathologica.

[26]  Carol Brayne,et al.  Age‐Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study , 2015, Brain pathology.

[27]  D. Werring,et al.  White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid , 2015, Brain pathology.

[28]  C. Nicholson,et al.  Clearance systems in the brain-implications for Alzheimer disease. , 2015, Nature reviews. Neurology.

[29]  Joanna M Wardlaw,et al.  What are White Matter Hyperintensities Made of? , 2015, Journal of the American Heart Association.

[30]  R. Carare,et al.  Stroke-induced opposite and age-dependent changes of vessel-associated markers in co-morbid transgenic mice with Alzheimer-like alterations , 2013, Experimental Neurology.

[31]  R O Weller,et al.  Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy , 2013, Neuropathology and applied neurobiology.

[32]  S. Love,et al.  Assessing White Matter Ischemic Damage in Dementia Patients by Measurement of Myelin Proteins , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  R. Carare,et al.  Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid‐β from the mouse brain , 2013, Aging cell.

[34]  K. Ji,et al.  Inflammation modulates expression of laminin in the central nervous system following ischemic injury , 2012, Journal of Neuroinflammation.

[35]  R. Kalaria,et al.  Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts , 2011, Acta Neuropathologica.

[36]  K. Jellinger,et al.  Review: Sporadic cerebral amyloid angiopathy , 2011, Neuropathology and applied neurobiology.

[37]  Reinhard Schliebs,et al.  Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy , 2011, Acta Neuropathologica.

[38]  L. Grinberg,et al.  Vascular pathology in the aged human brain , 2010, Acta Neuropathologica.

[39]  R O Weller,et al.  Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology , 2008, Neuropathology and applied neurobiology.

[40]  R. Carare,et al.  Lymphatic drainage of the brain and the pathophysiology of neurological disease , 2008, Acta Neuropathologica.

[41]  O. Wendler,et al.  Expression and function of laminins in the embryonic and mature vasculature. , 2005, Physiological reviews.

[42]  Jerry Silver,et al.  Astrocyte-Associated Fibronectin Is Critical for Axonal Regeneration in Adult White Matter , 2004, The Journal of Neuroscience.

[43]  J. O'Brien,et al.  Comparison of the pathology of cerebral white matter with post‐mortem magnetic resonance imaging (MRI) in the elderly brain , 2004, Neuropathology and applied neurobiology.

[44]  Carol P. Geer,et al.  Interstitial fluid flow along white matter tracts: A potentially important mechanism for the dissemination of primary brain tumors , 1997, Journal of Neuro-Oncology.

[45]  Tadashi Nagayama,et al.  Microvasculature of the human cerebral white matter: Arteries of the deep white matter , 2003, Neuropathology : official journal of the Japanese Society of Neuropathology.

[46]  M. Akima,et al.  The Microvasculature of the Cerebral White Matter: Arteries of the Subcortical White Matter , 2003, Journal of neuropathology and experimental neurology.

[47]  P. Martin,et al.  Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2. , 2002, Matrix biology : journal of the International Society for Matrix Biology.

[48]  E. Ruoslahti,et al.  The α5β1 Integrin Mediates Elimination of Amyloid-β Peptide and Protects Against Apoptosis , 1998, The Journal of cell biology.

[49]  J. Fike,et al.  Pathology of delayed radiation brain damage: an experimental canine model. , 1987, Radiation research.

[50]  C. Patlak,et al.  Convection of Cerebral Interstitial Fluid and Its Role in Brain Volume Regulation , 1986, Annals of the New York Academy of Sciences.

[51]  C. Patlak,et al.  Drainage of interstitial fluid from different regions of rat brain. , 1984, The American journal of physiology.

[52]  H. Duvernoy,et al.  Cortical blood vessels of the human brain , 1981, Brain Research Bulletin.

[53]  H F Cserr,et al.  Bulk flow of interstitial fluid after intracranial injection of blue dextran 2000. , 1974, Experimental neurology.

[54]  H. Wiśniewski,et al.  EXPERIMENTAL HYDROCEPHALUS IN YOUNG DOGS: HISTOLOGICL AND ULTRASTRUCTURAL STUDY OF THE BRAIN TISSUE DAMAGE , 1971, Journal of neuropathology and experimental neurology.

[55]  H. Wiśniewski,et al.  Histological and ultrastructural changes with experimental hydrocephalus in adult rabbits. , 1969, Brain : a journal of neurology.