In this paper, we develop an improved fault detection (FD) technique in order to enhance monitoring abilities of nonlinear chemical processes. Kernel principal component analysis (KPCA) is an effective data driven technique for monitoring nonlinear processes. However, it is well known that data collected from complex and multivariate processes are multiscale due to the variety of changes that could occur in process with different localization in time and frequency. Thus, to enhance process monitoring abilities, we propose to combine advantages of KPCA and multiscale representation using wavelets by constructing a multiscale KPCA model and a new detection chart named multiscale kernel generalized likelihood ratio test (MS-KGLRT) is derived for fault detection. The detection performance of the new chart is studied using the Tennessee Eastman process (TEP).