Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

[1]  J. Carroll,et al.  Pioneer factors in hormone-dependent cancers , 2012, Nature Reviews Cancer.

[2]  R. Chodankar,et al.  Gene-specific patterns of coregulator requirements by estrogen receptor-α in breast cancer cells. , 2012, Molecular endocrinology.

[3]  B. Katzenellenbogen,et al.  Phosphorylation by p38 Mitogen-Activated Protein Kinase Promotes Estrogen Receptor α Turnover and Functional Activity via the SCFSkp2 Proteasomal Complex , 2012, Molecular and Cellular Biology.

[4]  S. Keleş,et al.  Identification of Estrogen Receptor Dimer Selective Ligands Reveals Growth-Inhibitory Effects on Cells That Co-Express ERα and ERβ , 2012, PloS one.

[5]  S. Mandrup,et al.  Transcriptional networks and chromatin remodeling controlling adipogenesis , 2012, Trends in Endocrinology & Metabolism.

[6]  B. Katzenellenbogen,et al.  Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[7]  Marc E. Lenburg,et al.  Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657) , 2011, Breast Cancer Research and Treatment.

[8]  I. Ellis,et al.  Differential oestrogen receptor binding is associated with clinical outcome in breast cancer , 2011, Nature.

[9]  S. Gambhir,et al.  In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation. , 2011, Molecular endocrinology.

[10]  Wing-Kin Sung,et al.  Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state , 2011, Molecular systems biology.

[11]  Clifford A. Meyer,et al.  Cistrome: an integrative platform for transcriptional regulation studies , 2011, Genome Biology.

[12]  Marius C. Jones,et al.  Role of nuclear receptor corepressor RIP140 in metabolic syndrome☆ , 2011, Biochimica et biophysica acta.

[13]  B. Katzenellenbogen,et al.  Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis , 2011, Breast Cancer Research.

[14]  Leighton J. Core,et al.  A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells , 2011, Cell.

[15]  A. Huang,et al.  Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization , 2011, BMC Cancer.

[16]  Mario Cannataro,et al.  Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells. , 2011, Molecular bioSystems.

[17]  Lorenzo Ferraro,et al.  Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation , 2011, BMC Genomics.

[18]  J. Gustafsson,et al.  Estrogen Receptors: Therapies Targeted to Receptor Subtypes , 2011, Clinical pharmacology and therapeutics.

[19]  Tao Ye,et al.  seqMINER: an integrated ChIP-seq data interpretation platform , 2010, Nucleic acids research.

[20]  N. D. Clarke,et al.  Integrative model of genomic factors for determining binding site selection by estrogen receptor-α , 2010, Molecular systems biology.

[21]  F. Stossi,et al.  Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs , 2010, Molecular and Cellular Biology.

[22]  B. Komm,et al.  Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation , 2010, Molecular and Cellular Biology.

[23]  Cory Y. McLean,et al.  GREAT improves functional interpretation of cis-regulatory regions , 2010, Nature Biotechnology.

[24]  J. Darbon,et al.  The Transcriptional Coregulator RIP140 Represses E2F1 Activity and Discriminates Breast Cancer Subtypes , 2010, Clinical Cancer Research.

[25]  A. Malovannaya,et al.  Global characterization of transcriptional impact of the SRC-3 coregulator. , 2010, Molecular endocrinology.

[26]  Bertram Ludäscher,et al.  Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data , 2009, Nucleic acids research.

[27]  E. Liu,et al.  An Oestrogen Receptor α-bound Human Chromatin Interactome , 2009, Nature.

[28]  P. Farnham.  Insights from genomic profiling of transcription factors , 2009, Nature Reviews Genetics.

[29]  B. O’Malley,et al.  Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family , 2009, Nature Reviews Cancer.

[30]  H. Stunnenberg,et al.  ChIP‐Seq of ERα and RNA polymerase II defines genes differentially responding to ligands , 2009, The EMBO journal.

[31]  E. Powell,et al.  Intermolecular interactions identify ligand-selective activity of estrogen receptor α/β dimers , 2008, Proceedings of the National Academy of Sciences.

[32]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[33]  B. Katzenellenbogen,et al.  Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. , 2008, Molecular endocrinology.

[34]  B. Katzenellenbogen,et al.  Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer. , 2008, Cancer research.

[35]  F. Pépin,et al.  Stromal gene expression predicts clinical outcome in breast cancer , 2008, Nature Medicine.

[36]  Clifford A. Meyer,et al.  FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription , 2008, Cell.

[37]  J. Gustafsson,et al.  A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells , 2008, Oncogene.

[38]  Barry Komm,et al.  Estrogen-regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation. , 2007, Molecular endocrinology.

[39]  J. Carroll,et al.  Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state , 2007, Nature Reviews Cancer.

[40]  Jérôme Eeckhoute,et al.  Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor α Expression in Breast Cancer , 2007 .

[41]  F. Stossi,et al.  Whole-Genome Cartography of Estrogen Receptor α Binding Sites , 2007, PLoS genetics.

[42]  J. Bergh,et al.  Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer , 2007, Breast Cancer Research.

[43]  L. Saal,et al.  Estrogen Receptor β Expression Is Associated with Tamoxifen Response in ERα-Negative Breast Carcinoma , 2007, Clinical Cancer Research.

[44]  Clifford A. Meyer,et al.  Genome-wide analysis of estrogen receptor binding sites , 2006, Nature Genetics.

[45]  J. Frasor,et al.  Impact of Estrogen Receptor β on Gene Networks Regulated by Estrogen Receptor α in Breast Cancer Cells , 2006 .

[46]  R. Evans,et al.  Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network , 2006, Cell.

[47]  E. Leygue,et al.  Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours , 2006, British Journal of Cancer.

[48]  Chin-Yo Lin,et al.  Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. , 2006, Cancer research.

[49]  Jun S. Song,et al.  CEAS: cis-regulatory element annotation system , 2006, Nucleic Acids Res..

[50]  P. Balaguer,et al.  Transcriptional Regulation of the Human NRIP1/RIP140 Gene by Estrogen Is Modulated by Dioxin Signalling , 2006, Molecular Pharmacology.

[51]  K. Korach,et al.  Estrogen receptors and human disease. , 2006, The Journal of clinical investigation.

[52]  Masakazu Toi,et al.  Clinical significance of estrogen receptor β in breast cancer , 2005, Cancer Chemotherapy and Pharmacology.

[53]  E. Kiskinis,et al.  RIP140-Targeted Repression of Gene Expression in Adipocytes , 2005, Molecular and Cellular Biology.

[54]  Clifford A. Meyer,et al.  Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1 , 2005, Cell.

[55]  M. Louie,et al.  ACTR/AIB1 Functions as an E2F1 Coactivator To Promote Breast Cancer Cell Proliferation and Antiestrogen Resistance , 2004, Molecular and Cellular Biology.

[56]  Michael A. Beer,et al.  Predicting Gene Expression from Sequence , 2004, Cell.

[57]  V. Speirs,et al.  Oestrogen receptor β: what it means for patients with breast cancer , 2004 .

[58]  J. Hartman,et al.  Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D , 2004 .

[59]  G. Firestone,et al.  Estrogen Receptor β Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest , 2004, Cancer Research.

[60]  Barry Komm,et al.  Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. , 2003, Endocrinology.

[61]  Brad T. Sherman,et al.  DAVID: Database for Annotation, Visualization, and Integrated Discovery , 2003, Genome Biology.

[62]  Van,et al.  A gene-expression signature as a predictor of survival in breast cancer. , 2002, The New England journal of medicine.

[63]  B. Katzenellenbogen,et al.  Defining the "S" in SERMs , 2002, Science.

[64]  Neil J. McKenna,et al.  Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators , 2002, Cell.

[65]  B. Katzenellenbogen,et al.  Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. , 2001, Journal of medicinal chemistry.

[66]  G. Lazennec.  ER Inhibits Proliferation and Invasion of Breast Cancer Cells , 2001 .

[67]  A. Lucas,et al.  ERβ Inhibits Proliferation and Invasion of Breast Cancer Cells. , 2001, Endocrinology.

[68]  B. Katzenellenbogen,et al.  Human estrogen receptor beta-specific monoclonal antibodies: characterization and use in studies of estrogen receptor beta protein expression in reproductive tissues , 2001, Molecular and Cellular Endocrinology.

[69]  J. Thomsen,et al.  Mechanisms of estrogen action. , 2001, Physiological reviews.

[70]  B. Katzenellenbogen,et al.  Estrogen receptors: selective ligands, partners, and distinctive pharmacology. , 2000, Recent progress in hormone research.

[71]  Benita S Katzenellenbogen,et al.  Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta - regulation by selective estrogen receptor modulators and importance in breast cancer , 2000, Breast Cancer Research.

[72]  Simak Ali,et al.  Estrogen Receptor Alpha in Human Breast Cancer: Occurrence and Significance , 2000, Journal of Mammary Gland Biology and Neoplasia.

[73]  J. Font de Mora,et al.  AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor , 2000, Molecular and Cellular Biology.

[74]  C. Deng,et al.  The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[75]  J. Kurebayashi,et al.  Expression Levels of Estrogen Receptor-α, Estrogen Receptor-β, Coactivators, and Corepressors in Breast Cancer , 2000 .

[76]  C. Glass,et al.  The coregulator exchange in transcriptional functions of nuclear receptors. , 2000, Genes & development.

[77]  C. Lyttle,et al.  A Transcriptional Coactivator, Steroid Receptor Coactivator-3, Selectively Augments Steroid Receptor Transcriptional Activity* , 1998, The Journal of Biological Chemistry.

[78]  P. Meltzer,et al.  AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. , 1997, Science.

[79]  P. Kushner,et al.  Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. , 1995, The EMBO journal.

[80]  Y. Benjamini,et al.  More powerful procedures for multiple significance testing. , 1990, Statistics in medicine.

[81]  B. Katzenellenbogen,et al.  Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection. , 2010, Molecular endocrinology.

[82]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[83]  J. Eeckhoute,et al.  Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. , 2007, Cancer research.

[84]  L. Saal,et al.  Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. , 2007, Clinical cancer research : an official journal of the American Association for Cancer Research.

[85]  J. Frasor,et al.  Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. , 2006, Endocrinology.

[86]  H. Harris.  Preclinical characterization of selective estrogen receptor beta agonists: new insights into their therapeutic potential. , 2006, Ernst Schering Foundation symposium proceedings.

[87]  Masakazu Toi,et al.  Clinical significance of estrogen receptor beta in breast cancer. , 2005, Cancer chemotherapy and pharmacology.

[88]  V. Speirs,et al.  Oestrogen receptor beta: what it means for patients with breast cancer. , 2004, The Lancet. Oncology.

[89]  J. Hartman,et al.  Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[90]  G. Firestone,et al.  Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. , 2004, Cancer research.

[91]  A. Lucas,et al.  ER beta inhibits proliferation and invasion of breast cancer cells. , 2001, Endocrinology.

[92]  P. Meltzer,et al.  Association of steroid receptor coactivator AIB1 with estrogen receptor-alpha in breast cancer cells. , 2001, Breast cancer research and treatment.

[93]  K. Tanaka,et al.  Expression levels of estrogen receptor-alpha, estrogen receptor-beta, coactivators, and corepressors in breast cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.