Biomaterials to gene delivery.

It has been over 40 years since I started biomaterials research. This article is a short summary of past research in my laboratory.

[1]  T. Okano,et al.  Heparin immobilization onto segmented polyurethane-urea surfaces--effect of hydrophilic spacers. , 1988, Journal of biomedical materials research.

[2]  S. W. Kim,et al.  Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity. , 2008, Bioconjugate chemistry.

[3]  Teruo Okano,et al.  PGE1-Heparin conjugate releasing polymers , 1985 .

[4]  S. W. Kim,et al.  Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  S. W. Kim,et al.  Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-L-glycolic acid] [19] , 2000 .

[6]  S. W. Kim,et al.  Folate-PEG-Folate-Graft-Polyethylenimine-Based Gene Delivery , 2001, Journal of drug targeting.

[7]  T. Okano,et al.  A new thermo-sensitive hydrogel: Interpenetrating polymer networks from N-acryloylpyrrolidine and poly(oxyethylene) , 1988 .

[8]  Steven Edward Kern,et al.  Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[9]  S. W. Kim,et al.  The effect of surface modification of adenovirus with an arginine-grafted bioreducible polymer on transduction efficiency and immunogenicity in cancer gene therapy. , 2010, Biomaterials.

[10]  S. W. Kim,et al.  A self-regulating insulin delivery system. II. In vivo characteristics of a synthetic glycosylated insulin , 1989 .

[11]  J. Feijen,et al.  Drug-Coupled Poly(Amino Acids) as Polymeric Prodrugs , 1988 .

[12]  F. Liu,et al.  Polyethylene glycol-grafted poly-L-lysine as polymeric gene carrier. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[13]  T. Park,et al.  Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[14]  S. W. Kim,et al.  A self-regulating insulin delivery system. I. Characterization of a synthetic glycosylated insulin derivative , 1989 .

[15]  F. Liu,et al.  Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine and its complex with plasmid DNA. , 1999, Human gene therapy.

[16]  S. W. Kim,et al.  Self-regulated glycosylated insulin delivery , 1990 .

[17]  S. W. Kim,et al.  Self-regulating insulin delivery systems: III. In vivo studies , 1985 .

[18]  S. W. Kim,et al.  Cardiomyocyte-targeted siRNA delivery by prostaglandin E(2)-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis. , 2008, Biomaterials.

[19]  D. Bull,et al.  Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct , 2009, Gene Therapy.

[20]  A. Maruyama,et al.  A new non-viral DNA delivery vector: the terplex system. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[21]  S. W. Kim,et al.  Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice , 2000, Gene Therapy.

[22]  J. Andrade,et al.  Platelet adhesion to polymer surfaces. , 1974, Transactions - American Society for Artificial Internal Organs.

[23]  S. W. Kim,et al.  An angiogenic, endothelial-cell-targeted polymeric gene carrier. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[24]  S. W. Kim,et al.  Adsorption of proteins onto hydrophobic polymer surfaces: adsorption isotherms and kinetics. , 1974, Journal of biomedical materials research.

[25]  S. W. Kim,et al.  Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium. , 2011, Biomaterials.

[26]  D. Gregonis,et al.  CONTROLLED RELEASE OF PROGESTINS FROM poly(α-AMINO ACID) CARRIERS , 1980 .

[27]  S. W. Kim,et al.  Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium. , 2010, Biomaterials.

[28]  J. Feijen,et al.  Coupling of Naltrexone to Biodegradable Poly(α-Amino Acids) , 1987, Pharmaceutical Research.

[29]  Sung Wan Kim,et al.  Biodegradable block copolymers as injectable drug-delivery systems , 1997, Nature.

[30]  S. W. Kim,et al.  A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[31]  S. W. Kim,et al.  Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[32]  R. Mahato,et al.  Intratumoral delivery of p2CMVmIL-12 using water-soluble lipopolymers. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

[33]  S. W. Kim,et al.  Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[34]  J. Feijen,et al.  Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. I. Synthesis and characterization. , 1988, Journal of biomedical materials research.

[35]  S. W. Kim,et al.  GLP-1 gene delivery for the treatment of type 2 diabetes. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

[36]  Y. Bae,et al.  Electrically credible polymer gel for controlled release of drugs , 1991, Nature.

[37]  J. Feijen,et al.  Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery. , 2006, Bioconjugate chemistry.

[38]  T. Okano,et al.  Thermo-sensitive polymers as on-off switches for drug release , 1987 .