Urinary bladder amyloidosis presenting as recurrent cystitis

Urinary bladder amyloidosis is rare. Our patient had a history of repeated lower urinary tract symptoms for the last 2 years, for which she was treated as urinary tract infection. Ultrasonography showed thick urinary bladder wall. She underwent cystoscopy and biopsy was performed. Immunostaining of the biopsy material with Congo red stain showed the presence of amyloid fibrils within the biopsy. Amyloid A (AA) staining was negative. Immunohistochemistry (IHC) showed faint Kappa band positivity along amyloid deposits. Serum-free light chain assay and serum protein electrophoresis report were normal. Thus, we report a rare case of urinary bladder limited amyloidosis who presented with frequent lower urinary tract symptoms.