The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA

Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across all eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.

[1]  R. Martienssen,et al.  DNA methylation and epigenetic inheritance in plants and filamentous fungi. , 2001, Science.

[2]  M. Roth,et al.  Hcp-4, a Cenp-C–Like Protein inCaenorhabditis elegans, Is Required for Resolution of Sister Centromeres , 2001, The Journal of cell biology.

[3]  K. Oegema,et al.  Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans , 2001, The Journal of cell biology.

[4]  R. Kellum,et al.  Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing. , 2001, Molecular biology of the cell.

[5]  A. Meister,et al.  Chromatin organization and its relation to replication and histone acetylation during the cell cycle in barley , 2001, Chromosoma.

[6]  C. Sapienza,et al.  Nonrandom segregation during meiosis: the unfairness of females , 2001, Mammalian Genome.

[7]  D. Magliano,et al.  A 330 kb CENP‐A binding domain and altered replication timing at a human neocentromere , 2001, The EMBO journal.

[8]  S. Henikoff,et al.  Centromeres Are Specialized Replication Domains in Heterochromatin , 2001, The Journal of cell biology.

[9]  K. Sullivan,et al.  A solid foundation: functional specialization of centromeric chromatin. , 2001, Current opinion in genetics & development.

[10]  D. Magliano,et al.  A novel chromatin immunoprecipitation and array (CIA) analysis identifies a 460-kb CENP-A-binding neocentromere DNA. , 2001, Genome research.

[11]  S. Henikoff,et al.  Adaptive evolution of Cid, a centromere-specific histone in Drosophila. , 2001, Genetics.

[12]  G. Almouzni,et al.  Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases , 2001, Nature Cell Biology.

[13]  E. O'Toole,et al.  The spindle cycle in budding yeast , 2001, Nature Cell Biology.

[14]  C. Tyler-Smith,et al.  Mapping of a human centromere onto the DNA by topoisomerase II cleavage , 2000, EMBO reports.

[15]  K. Sullivan,et al.  Chromatin Assembly at Kinetochores Is Uncoupled from DNA Replication , 2000, The Journal of cell biology.

[16]  W. Brown,et al.  Human mini-chromosomes with minimal centromeres. , 2000, Human molecular genetics.

[17]  J. McIntosh,et al.  CENP-meta, an Essential Kinetochore Kinesin Required for the Maintenance of Metaphase Chromosome Alignment in Drosophila , 2000, Journal of Cell Biology.

[18]  M. Yanagida,et al.  Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast. , 2000, Science.

[19]  K. Yoda,et al.  Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[20]  S. Schwartz,et al.  Molecular cytogenetic analysis of eight inversion duplications of human chromosome 13q that each contain a neocentromere. , 2000, American journal of human genetics.

[21]  J. Abad,et al.  A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation , 2000, Chromosoma.

[22]  R. Allshire,et al.  Distinct protein interaction domains and protein spreading in a complex centromere. , 2000, Genes & development.

[23]  K. Choo,et al.  Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  K. Choo,et al.  Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins. , 2000, Human molecular genetics.

[25]  S. Henikoff,et al.  Heterochromatic deposition of centromeric histone H3-like proteins. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[26]  C. Sapienza,et al.  Transmission ratio distortion in offspring of heterozygous female carriers of Robertsonian translocations , 2000, Human Genetics.

[27]  D. Tautz,et al.  Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism. , 1999, Genetics.

[28]  K. Sullivan,et al.  CENP-A associated complex satellite DNA in the kinetochore of the Indian muntjac , 1999, Chromosoma.

[29]  R. Allshire,et al.  Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation. , 1999, Genetics.

[30]  S. Henikoff,et al.  Cell division: A histone-H3-like protein in C. elegans , 1999, Nature.

[31]  R. Paro,et al.  Chromosomal elements conferring epigenetic inheritance. , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[32]  R. Baker,et al.  Analysis of Primary Structural Determinants That Distinguish the Centromere-Specific Function of Histone Variant Cse4p from Histone H3 , 1999, Molecular and Cellular Biology.

[33]  J. Doebley,et al.  Meiotic drive of chromosomal knobs reshaped the maize genome. , 1999, Genetics.

[34]  H. Willard,et al.  Chromosome engineering: generation of mono- and dicentric isochromosomes in a somatic cell hybrid system , 1999, Chromosoma.

[35]  C. Langley,et al.  Genetic variation in rates of nondisjunction: association of two naturally occurring polymorphisms in the chromokinesin nod with increased rates of nondisjunction in Drosophila melanogaster. , 1999, Genetics.

[36]  B. Sheldon.  Sex allocation: At the females' whim , 1999, Current Biology.

[37]  C. Tyler-Smith,et al.  Transmission of a fully functional human neocentromere through three generations. , 1999, American journal of human genetics.

[38]  O. Stemmann,et al.  A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. , 1999, Genes & development.

[39]  A. Billault,et al.  Genetic and physical analyses of the centromeric and pericentromeric regions of human chromosome 5: recombination across 5cen. , 1999, Genomics.

[40]  W. Earnshaw,et al.  Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression. , 1999, Experimental cell research.

[41]  U. W. Kenkare,et al.  Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. , 1999, Experimental cell research.

[42]  J. Birchler,et al.  Meiotic transmission rates correlate with physical features of rearranged centromeres in maize. , 1998, Genetics.

[43]  R. Quatrano.  Genomics , 1998, Plant Cell.

[44]  H. Willard,et al.  Stable dicentric X chromosomes with two functional centromeres , 1998, Nature Genetics.

[45]  S. Grewal,et al.  Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. , 1998, Genetics.

[46]  D. Koshland,et al.  Cse4p Is a Component of the Core Centromere of Saccharomyces cerevisiae , 1998, Cell.

[47]  J. Carbon,et al.  Structure of the Chromosome VII Centromere Region in Neurospora crassa: Degenerate Transposons and Simple Repeats , 1998, Molecular and Cellular Biology.

[48]  S. Jackson,et al.  Rice (Oryza sativa) centromeric regions consist of complex DNA. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[49]  S Henikoff,et al.  Something from nothing: the evolution and utility of satellite repeats. , 1998, Trends in genetics : TIG.

[50]  H. Masumoto,et al.  Construction of YAC–based mammalian artificial chromosomes , 1998, Nature Biotechnology.

[51]  B. McKee,et al.  Male sterility and meiotic drive associated with sex chromosome rearrangements in Drosophila. Role of X-Y pairing. , 1998, Genetics.

[52]  G. Karpen,et al.  Centromeres Take Flight: Alpha Satellite and the Quest for the Human Centromere , 1998, Cell.

[53]  H. Willard,et al.  Centromeres: the missing link in the development of human artificial chromosomes. , 1998, Current opinion in genetics & development.

[54]  H. A. Orr,et al.  The evolutionary genetics of speciation. , 1998, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[55]  K. Choo,et al.  Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[56]  B. Turner,et al.  Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres , 1997, Cell.

[57]  G. Karpen,et al.  Molecular Structure of a Functional Drosophila Centromere , 1997, Cell.

[58]  G. Karpen,et al.  The case for epigenetic effects on centromere identity and function. , 1997, Trends in genetics : TIG.

[59]  C. Laurie,et al.  Dove The Weaker Sex Is Heterogametic : 75 Years of HALDANE ’ S Rule , 2002 .

[60]  K. Sullivan,et al.  Chromatin containing CENP-A and α-satellite DNA is a major component of the inner kinetochore plate , 1997, Current Biology.

[61]  C. Tyler-Smith,et al.  Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres , 1997, Current Biology.

[62]  T. Richmond,et al.  Crystal structure of the nucleosome core particle at 2.8 Å resolution , 1997, Nature.

[63]  Huntington F. Willard,et al.  Chromosome-specific α-satellite DNA from the centromere of chimpanzee chromosome 4 , 1997, Chromosoma.

[64]  S. Schwartz,et al.  Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA. , 1997, Human molecular genetics.

[65]  H. Willard,et al.  Formation of de novo centromeres and construction of first-generation human artificial microchromosomes , 1997, Nature Genetics.

[66]  K. Sullivan,et al.  Assembly of CENP-A into Centromeric Chromatin Requires a Cooperative Array of Nucleosomal DNA Contact Sites , 1997, The Journal of cell biology.

[67]  R. Dawe,et al.  Induction of centromeric activity in maize by suppressor of meiotic drive 1. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[68]  A. Mccarthy.  Development , 1996, Current Opinion in Neurobiology.

[69]  F. Maytag.  Evolution , 1996, Arch. Mus. Informatics.

[70]  R. Wickner,et al.  [PSI] and [URE3] as yeast prions , 1995, Yeast.

[71]  G. Karpen,et al.  Localization of centromere function in a drosophila minichromosome , 1995, Cell.

[72]  L. Clarke,et al.  A novel epigenetic effect can alter centromere function in fission yeast , 1994, Cell.

[73]  K. Sullivan,et al.  Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere , 1994, The Journal of cell biology.

[74]  Wolfgang Stephan,et al.  The evolutionary dynamics of repetitive DNA in eukaryotes , 1994, Nature.

[75]  G. Dover,et al.  Evolution of genetic redundancy for advanced players. , 1993, Current opinion in genetics & development.

[76]  S. Henikoff,et al.  Somatic instability of a Drosophila chromosome. , 1992, Genetics.

[77]  D L Spector,et al.  Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences , 1992, The Journal of cell biology.

[78]  L. Hurst,et al.  Causes of sex ratio bias may account for unisexual sterility in hybrids: a new explanation of Haldane's rule and related phenomena. , 1991, Genetics.

[79]  R. Margolis,et al.  Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[80]  H. Willard,et al.  Centromeres of mammalian chromosomes. , 1990, Trends in genetics : TIG.

[81]  V. Jackson.  Deposition of newly synthesized histones: hybrid nucleosomes are not tandemly arranged on daughter DNA strands. , 1988, Biochemistry.

[82]  M. Baum,et al.  Structural organization and functional analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe , 1988, Molecular and cellular biology.

[83]  A. Murdoch.  Cloning , 2007, Ethics & Medics.

[84]  J. Erickson.  What Is the Centromere , 1979 .

[85]  B. Bainbridge,et al.  Genetics , 1981, Experientia.

[86]  E. Novitski.  Genetic measures of centromere activity in Drosophila melanogaster. , 1955, Journal of cellular physiology. Supplement.

[87]  M. Rhoades.  Preferential Segregation in Maize. , 1942, Genetics.