Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice

[1]  A. Palmeri,et al.  F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice , 2013, Hippocampus.

[2]  D. Puzzo,et al.  Role of Cyclic Nucleotide-Gated Channels in the Modulation of Mouse Hippocampal Neurogenesis , 2013, PloS one.

[3]  J. Jordán,et al.  Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. , 2013, Biochimica et biophysica acta.

[4]  M. Halushka,et al.  Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model. , 2013, Acta cirurgica brasileira.

[5]  A. Palmeri,et al.  Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory , 2013, Behavioural Brain Research.

[6]  E. Calabrese,et al.  Hormesis: its impact on medicine and health. , 2013, Human & experimental toxicology.

[7]  E. Fedele,et al.  Cyclic adenosine monophosphate as an endogenous modulator of the amyloid‐β precursor protein metabolism , 2013, IUBMB life.

[8]  H. Atteia,et al.  Sildenafil citrate attenuates the deleterious effects of elevated ammonia , 2013, Toxicology mechanisms and methods.

[9]  G. Musumeci,et al.  β-Defensin-4 (HBD-4) is expressed in chondrocytes derived from normal and osteoarthritic cartilage encapsulated in PEGDA scaffold. , 2012, Acta histochemica.

[10]  E. Y. Kim,et al.  Renoprotective Effects of Sildenafil in DOCA-Salt Hypertensive Rats , 2012, Kidney and Blood Pressure Research.

[11]  C. Tschöpe,et al.  Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo , 2012, Basic Research in Cardiology.

[12]  M. Podda,et al.  Expression of olfactory‐type cyclic nucleotide‐gated channels in rat cortical astrocytes , 2012, Glia.

[13]  A. Palmeri,et al.  Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory , 2012, Neurobiology of Aging.

[14]  S. Cuzzocrea,et al.  Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. , 2012, Biochimica et biophysica acta.

[15]  Denise C. Park,et al.  &bgr;-Amyloid burden in healthy aging: Regional distribution and cognitive consequences , 2012, Neurology.

[16]  N. Uysal,et al.  Age-related changes in apoptosis in rat hippocampus induced by oxidative stress , 2012, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

[17]  K. Tomizawa,et al.  Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation , 2012, Neuroscience.

[18]  Thomas L. Williams,et al.  Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease* , 2011, The Journal of Biological Chemistry.

[19]  R. Franco,et al.  Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease , 2011, British journal of pharmacology.

[20]  L. V. von Segesser,et al.  Phosphodiesterase-5 Inhibition Mimics Intermittent Reoxygenation and Improves Cardioprotection in the Hypoxic Myocardium , 2011, PloS one.

[21]  M. Chopp,et al.  Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice , 2011, Neuroscience.

[22]  J. Elisseeff,et al.  OA cartilage derived chondrocytes encapsulated in poly(ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in vitro model. , 2011, Histology and histopathology.

[23]  F. Ercan,et al.  The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis. , 2011, Life sciences.

[24]  S. Cuzzocrea,et al.  Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. , 2011, Molecular aspects of medicine.

[25]  Zhuo Yang,et al.  Protective Effects of YC-1 Against Glutamate Induced PC12 Cell Apoptosis , 2011, Cellular and Molecular Neurobiology.

[26]  E. Huri,et al.  Phosphodiesterase 5 inhibitors attenuate renal tubular apoptosis after partial unilateral ureteral obstruction: An experimental study , 2011, The Kaohsiung journal of medical sciences.

[27]  M. Mattson,et al.  Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. , 2010, Antioxidants & redox signaling.

[28]  Inna Kuperstein,et al.  Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio , 2010, The EMBO journal.

[29]  I. Ziv,et al.  Editorial: apoptosis in the aging brain , 2010, Apoptosis.

[30]  L. Rashed,et al.  Testosterone and chronic sildenafil/tadalafil anti-apoptotic role in aged diabetic rats , 2010, International Journal of Impotence Research.

[31]  J. Jordán,et al.  Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF , 2010, Neurobiology of Disease.

[32]  Mal-Soon Shin,et al.  Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus , 2010, Experimental Gerontology.

[33]  E. McAuley,et al.  Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume , 2010, The Journal of Neuroscience.

[34]  J. P. Andrade,et al.  Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival. , 2010, Free radical biology & medicine.

[35]  J. Strosznajder,et al.  Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease , 2010, Molecular Neurobiology.

[36]  S. Gulsen,et al.  The effect of the sildenafil citrate on cerebral vasospasm and apoptosis following experimental subarachnoid hemorrhage in rats. , 2010, Journal of neurosurgical sciences.

[37]  Yong Li,et al.  Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus , 2009, Behavioural Brain Research.

[38]  M. Ghasemi,et al.  Sildenafil decreased cardiac cell apoptosis in diabetic mice: reduction of oxidative stress as a possible mechanism. , 2009, Canadian journal of physiology and pharmacology.

[39]  A. Palmeri,et al.  Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-β Load in an Alzheimer's Disease Mouse Model , 2009, The Journal of Neuroscience.

[40]  Q. Li,et al.  Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic amp-response element binding protein signaling cascade , 2009, Neuroscience.

[41]  L. Placanica,et al.  Gender- and Age-Dependent γ-Secretase Activity in Mouse Brain and Its Implication in Sporadic Alzheimer Disease , 2009, PloS one.

[42]  K. Kim,et al.  Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils , 2009, Pharmacology Biochemistry and Behavior.

[43]  A. Palmeri,et al.  Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus , 2008, The Journal of Neuroscience.

[44]  M. Silhol,et al.  New insights into brain BDNF function in normal aging and Alzheimer disease , 2008, Brain Research Reviews.

[45]  D. Bennett,et al.  Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. , 2008, The American journal of pathology.

[46]  M. Guazzi,et al.  Phosphodiesterase-5 Inhibition Abolishes Neuron Apoptosis Induced by Chronic Hypoxia Independently of Hypoxia-Inducible Factor-1α Signaling , 2008, Experimental biology and medicine.

[47]  M. Greenberg,et al.  SnapShot: Ca2+-Dependent Transcription in Neurons , 2008, Cell.

[48]  Giovanni Pennisi,et al.  Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity , 2008, Neurochemical Research.

[49]  S. Chiou,et al.  Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway , 2008, European Neuropsychopharmacology.

[50]  M. Podda,et al.  Functional role of cyclic nucleotide‐gated channels in rat medial vestibular nucleus neurons , 2008, The Journal of physiology.

[51]  O. Arancio,et al.  Neurotrophins, synaptic plasticity and dementia , 2007, Current Opinion in Neurobiology.

[52]  S. Elmore Apoptosis: A Review of Programmed Cell Death , 2007, Toxicologic pathology.

[53]  R. Quirion,et al.  Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease , 2007, Neurobiology of Aging.

[54]  Jing Liu,et al.  Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats , 2006, Brain Research.

[55]  J. Kleinman,et al.  BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. , 2006, Gene expression patterns : GEP.

[56]  K. Yoo,et al.  Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging , 2006, Experimental Neurology.

[57]  Li-Hsin Chen,et al.  Moclobemide upregulated Bcl‐2 expression and induced neural stem cell differentiation into serotoninergic neuron via extracellular‐regulated kinase pathway , 2006, British journal of pharmacology.

[58]  Sheng-Xi Wu,et al.  Changes of apoptosis-related proteins in hippocampus of SAM mouse in development and aging , 2006, Neurobiology of Aging.

[59]  N. Madias,et al.  CREB transcription factor modulates Bcl2 transcription in response to C5a in HL‐60‐derived neutrophils , 2006, European journal of clinical investigation.

[60]  S. Kanba,et al.  Age-related disturbance of memory and CREB phosphorylation in CA1 area of hippocampus of rats , 2005, Brain Research.

[61]  A. Palmeri,et al.  Amyloid-β Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity , 2005, The Journal of Neuroscience.

[62]  P. Fisher,et al.  Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity , 2005, Circulation.

[63]  Anindita Das,et al.  Phosphodiesterase-5 Inhibitor Sildenafil Preconditions Adult Cardiac Myocytes against Necrosis and Apoptosis , 2005, Journal of Biological Chemistry.

[64]  E. Wang,et al.  Senescent fibroblasts resist apoptosis by downregulating caspase-3 , 2004, Mechanisms of Ageing and Development.

[65]  J. Virchow,et al.  The impact of age, weight and gender on BDNF levels in human platelets and plasma , 2004, Neurobiology of Aging.

[66]  K. Ha,et al.  Regulation of programmed cell death in neuronal cells by nitric oxide. , 2004, In vivo.

[67]  F. Gomez-Pinilla,et al.  The interplay between oxidative stress and brain‐derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition , 2004, The European journal of neuroscience.

[68]  J. Dorszewska,et al.  Apoptotic proteins in the course of aging of central nervous system in the rat , 2004, Respiratory Physiology & Neurobiology.

[69]  T. Billiar,et al.  Nitric oxide prevents 6‐hydroxydopamine‐induced apoptosis in PC12 cells through cGMP‐dependent PI3 kinase/Akt activation , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[70]  L. Kaczmarek,et al.  Inducible cAMP Early Repressor, an Endogenous Antagonist of cAMP Responsive Element-Binding Protein, Evokes Neuronal Apoptosis In Vitro , 2003, The Journal of Neuroscience.

[71]  M. Kim,et al.  Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats , 2002, Brain Research.

[72]  D. Selkoe Alzheimer's Disease Is a Synaptic Failure , 2002, Science.

[73]  Bin Yang,et al.  A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. , 2002, Kidney international.

[74]  E. Melamed,et al.  Antioxidant Therapy in Acute Central Nervous System Injury: Current State , 2002, Pharmacological Reviews.

[75]  M. Lynch,et al.  The age‐related increase in IL‐1 type I receptor in rat hippocampus is coupled with an increase in caspase‐3 activation , 2002, The European journal of neuroscience.

[76]  D. Ginty,et al.  CREB family transcription factors inhibit neuronal suicide , 2002, Nature Medicine.

[77]  A. Riccio,et al.  Apoptosis, Axonal Growth Defects, and Degeneration of Peripheral Neurons in Mice Lacking CREB , 2002, Neuron.

[78]  C. Leeuwenburgh,et al.  The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart , 2002, Annals of the New York Academy of Sciences.

[79]  S. Jang,et al.  Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator. , 2002, Journal of biochemistry and molecular biology.

[80]  A. Baba,et al.  Anti-apoptotic Effect of cGMP in Cultured Astrocytes , 2001, The Journal of Biological Chemistry.

[81]  M. Hayashi,et al.  Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey , 2001, Brain Research.

[82]  C. Leeuwenburgh,et al.  Apoptosis and aging: role of the mitochondria. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[83]  R. Fiscus,et al.  Nitric Oxide and Cyclic GMP as Pro‐and Anti‐Apoptotic Agents , 2001, Journal of cardiac surgery.

[84]  R. Balázs,et al.  β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised* , 2001, The Journal of Biological Chemistry.

[85]  P. Bickford,et al.  Oxidative‐stress‐dependent up‐regulation of Bcl‐2 expression in the central nervous system of aged Fisher‐344 rats , 2001, Journal of neurochemistry.

[86]  Mark P. Mattson,et al.  Apoptosis in neurodegenerative disorders , 2000, Nature Reviews Molecular Cell Biology.

[87]  M. Dragunow,et al.  Is CREB a key to neuronal survival? , 2000, Trends in Neurosciences.

[88]  E. Kandel,et al.  Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus , 1999, The Journal of Neuroscience.

[89]  T. Billiar,et al.  Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling , 1999, The Journal of Neuroscience.

[90]  D. Seol,et al.  Nitric Oxide Suppression of Apoptosis Occurs in Association with an Inhibition of Bcl-2 Cleavage and Cytochrome cRelease* , 1998, The Journal of Biological Chemistry.

[91]  S. Shimohama,et al.  Differential expression of rat brain bcl-2 family proteins in development and aging. , 1998, Biochemical and biophysical research communications.

[92]  M. Tohyama,et al.  Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide , 1998, Cell Death and Differentiation.

[93]  M. Chalimoniuk,et al.  Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum. Effects of amyloid beta peptide. , 1998, Molecular and chemical neuropathology.

[94]  I. Takeuchi,et al.  Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3 , 1998, Neuroscience Research.

[95]  B. Pappas,et al.  Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment , 1998, Neuroreport.

[96]  T. Billiar,et al.  Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms* , 1997, The Journal of Biological Chemistry.

[97]  G M Cohen,et al.  Caspases: the executioners of apoptosis. , 1997, The Biochemical journal.

[98]  A. Yamashita,et al.  Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging , 1997, Brain Research.

[99]  M. Asanuma,et al.  Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor. , 1996, Brain research. Molecular brain research.

[100]  L. Greene,et al.  Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[101]  Steven A. Johnson,et al.  BDNF and trkB mRNA expression in the hippocampal formation of aging rats , 1993, Neurobiology of Aging.

[102]  S. Ben‐Sasson,et al.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation , 1992, The Journal of cell biology.

[103]  R. Schmidt-Kastner,et al.  Selective vulnerability of the hippocampus in brain ischemia , 1991, Neuroscience.

[104]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[105]  A. Bacci,et al.  Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease , 2011, Nature Neuroscience.

[106]  A. Ahmadiani,et al.  Apoptosis Inhibition Can Be Threatening in Aβ-Induced Neuroinflammation, Through Promoting Cell Proliferation , 2010, Neurochemical Research.

[107]  C. Berteotti,et al.  Dysregulation of memory‐related proteins in the hippocampus of aged rats and their relation with cognitive impairment , 2005, Hippocampus.

[108]  S. Schmidt,et al.  ELISA Method for Measurement of Amyloid-ß Levels , 2005 .

[109]  Wolfgang Schmid,et al.  Disruption of CREB function in brain leads to neurodegeneration , 2002, Nature Genetics.

[110]  J. Bueller,et al.  Frontiers in Aging Neuroscience Aging Neuroscience Involvement of Bdnf in Age-dependent Alterations in the Hippocampus Brain-derived Neurotrophic Factor (bdnf) , 2022 .