Normalization of transcranial magnetic stimulation points by means of atlas registration

Transcranial magnetic stimulation (TMS) is a well-known technique to study brain function. Location of TMS points can be visualized on the subject's Magnetic Resonance Image (MRI). However inter-subject comparison is possible only after a normalization i.e. a transformation of the stimulation points to a reference atlas image. Here, we propose a generic and automatic image processing pipe-line for normalizing a collection of subjects' MRI and TMS points. The normalization uses a loop of rigid-transform followed by Basis-Splines registration. The used reference atlas is the common Montreal National Institute (MNI) brain atlas [2]. We show preliminary results from 10 subjects. Those normalized points were compared to the SPM normalization and validated by TMS experts.

[1]  Jorge Nocedal,et al.  On the limited memory BFGS method for large scale optimization , 1989, Math. Program..

[2]  Terry M. Peters,et al.  3D statistical neuroanatomical models from 305 MRI volumes , 1993, 1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference.

[3]  Karl J. Friston,et al.  Spatial registration and normalization of images , 1995 .

[4]  Max A. Viergever,et al.  A survey of medical image registration , 1998, Medical Image Anal..

[5]  David R. Haynor,et al.  Nonrigid multimodality image registration , 2001, SPIE Medical Imaging.

[6]  M. Davare,et al.  Behavioral / Systems / Cognitive Dissociating the Role of Ventral and Dorsal Premotor Cortex in Precision Grasping , 2018 .

[7]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[8]  M. Hallett.  Transcranial magnetic stimulation and the human brain , 2000, Nature.

[9]  Luis Ibáñez,et al.  The ITK Software Guide , 2005 .

[10]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[11]  Benoit M. Macq,et al.  Registration and real-time visualization of transcranial magnetic stimulation with 3-D MR images , 2004, IEEE Transactions on Biomedical Engineering.

[12]  J. Spall.  Multivariate stochastic approximation using a simultaneous perturbation gradient approximation , 1992 .