Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.

[1]  Siobhan M. Dolan,et al.  Assessment of cumulative evidence on genetic associations: interim guidelines. , 2008, International journal of epidemiology.

[2]  R. Eastell,et al.  Variation in the secreted frizzled‐related protein‐3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[3]  Monique M. B. Breteler,et al.  The Rotterdam Study: 2016 objectives and design update , 2015, European Journal of Epidemiology.

[4]  A. Hofman,et al.  The Rotterdam Study: objectives and design update , 2007, European Journal of Epidemiology.

[5]  P. Donnelly,et al.  Replicating genotype–phenotype associations , 2007, Nature.

[6]  A. Myers,et al.  Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease , 2007, Proceedings of the National Academy of Sciences.

[7]  D. Kiel,et al.  Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. , 2007, Bone.

[8]  J. Gómez-Reino,et al.  Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis , 2007, Annals of the rheumatic diseases.

[9]  A. Hofman,et al.  Is diabetes mellitus a risk factor for open-angle glaucoma? The Rotterdam Study. , 2006, Ophthalmology.

[10]  Fernando Rivadeneira,et al.  Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin‐Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[11]  T. Spector,et al.  When is a replication not a replication? Or how to spot a good genetic association study. , 2006, Arthritis and rheumatism.

[12]  M. Nevitt,et al.  Frizzled-related protein variants are risk factors for hip osteoarthritis. , 2006, Arthritis and rheumatism.

[13]  Albert Hofman,et al.  Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study , 2006, Circulation.

[14]  A. Hofman,et al.  Common Genetic Variation of the Low‐Density Lipoprotein Receptor‐Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  K. Yates,et al.  Wnt influence on chondrocyte differentiation and cartilage function. , 2005, DNA and cell biology.

[16]  J. Kirwan,et al.  Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: are they a risk factor in osteoarthritis? , 2005, Osteoarthritis and cartilage.

[17]  Yukio Nakamura,et al.  Expression profiles and functional analyses of Wnt-related genes in human joint disorders. , 2005, The American journal of pathology.

[18]  Walter Birchmeier,et al.  Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. , 2005, Developmental cell.

[19]  J. Houwing-Duistermaat,et al.  Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. , 2005, Arthritis and rheumatism.

[20]  P. Dieppe,et al.  Pathogenesis and management of pain in osteoarthritis , 2005, The Lancet.

[21]  J. Westendorf,et al.  Wnt signaling in osteoblasts and bone diseases. , 2004, Gene.

[22]  A. Uitterlinden,et al.  Influence of LRP5 Polymorphisms on Normal Variation in BMD , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  B. Koes,et al.  Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study) , 2004, Annals of the rheumatic diseases.

[24]  A. Uitterlinden,et al.  A new marker for osteoarthritis: cross-sectional and longitudinal approach. , 2004, Arthritis and rheumatism.

[25]  L. Southam,et al.  Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Hofman,et al.  Homocysteine levels and the risk of osteoporotic fracture. , 2004, The New England journal of medicine.

[27]  E. Dermitzakis,et al.  Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. , 2004, American journal of human genetics.

[28]  N. Niikawa,et al.  LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density , 2004, Journal of Human Genetics.

[29]  A. Hofman,et al.  Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: the Rotterdam Study. , 2003, Arthritis and rheumatism.

[30]  C. Marcelle,et al.  Wnt regulation of chondrocyte differentiation , 2002, Journal of Cell Science.

[31]  T. Huh,et al.  Regulation of the chondrocyte phenotype by β-catenin , 2002 .

[32]  Changshan Wu,et al.  The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. , 2002, Developmental biology.

[33]  M. Dougados,et al.  Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. , 2002, Arthritis and rheumatism.

[34]  L. Hofbauer,et al.  High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.

[35]  Richard P Lifton,et al.  High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.

[36]  G. Karsenty,et al.  Regulation of bone formation and vision by LRP5. , 2002, The New England journal of medicine.

[37]  Miikka Vikkula,et al.  LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.

[38]  P. Qvist,et al.  Collagen type II C-telopeptide fragments as an index of cartilage degradation. , 2001, Bone.

[39]  E. Vignon,et al.  Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage , 2001, Annals of the rheumatic diseases.

[40]  T. Spector,et al.  Recommendations for the registration of drugs used in the treatment of osteoarthritis: an update on biochemical markers. , 2001, Osteoarthritis and cartilage.

[41]  Yoichi Kato,et al.  LDL-receptor-related proteins in Wnt signal transduction , 2000, Nature.

[42]  A. Hofman,et al.  Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study , 1998, Annals of the rheumatic diseases.

[43]  F. Luyten,et al.  The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[44]  T. Spector,et al.  The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. , 1994, Annals of the rheumatic diseases.

[45]  T. Spector,et al.  The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. , 1993, The Journal of rheumatology.

[46]  T. Spector,et al.  Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford study. , 1993, Annals of the rheumatic diseases.

[47]  J. Garrow,et al.  A survey of heights and weights of adults in Great Britain, 1980. , 1985, Annals of human biology.

[48]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.

[49]  T. Spector,et al.  Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. , 2007, Arthritis and rheumatism.

[50]  F. Luyten,et al.  Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. , 2006, Rheumatology.

[51]  Paolo Vineis,et al.  A road map for efficient and reliable human genome epidemiology , 2006, Nature Genetics.

[52]  The Atlas of Standard Radiographs of Arthritis. , 2005, Rheumatology.

[53]  T. Spector,et al.  Risk factors for osteoarthritis: genetics. , 2004, Osteoarthritis and cartilage.

[54]  P. Delmas,et al.  Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. , 2002, Arthritis and rheumatism.

[55]  Mark L. Johnson,et al.  A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. , 2002, American journal of human genetics.

[56]  T. Huh,et al.  Regulation of the chondrocyte phenotype by beta-catenin. , 2002, Development.