Obesity, Diabetes, and Cardiovascular Diseases Compendium Lipid Use and Misuse by the Heart
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[1] E. Lewandowski,et al. Triacylglycerol turnover in the failing heart. , 2016, Biochimica et biophysica acta.
[2] M. Fischereder,et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. , 2016, The New England journal of medicine.
[3] R. Bellomo,et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). , 2016, JAMA.
[4] J. Stamler,et al. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. , 2015, The Journal of clinical investigation.
[5] Min-Jeong Shin,et al. Alteration in Metabolic Signature and Lipid Metabolism in Patients with Angina Pectoris and Myocardial Infarction , 2015, PloS one.
[6] J. Penninger,et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity , 2015, Diabetes.
[7] Ratnesh K Singh,et al. Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice , 2015, Molecular and Cellular Biology.
[8] R. Tian,et al. Enhancing Cardiac Triacylglycerol Metabolism Improves Recovery From Ischemic Stress , 2015, Diabetes.
[9] Marc Prentki,et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes , 2015, Diabetes.
[10] S. Kato,et al. Impact of diabetes mellitus on myocardial lipid deposition: an autopsy study. , 2014, Pathology, research and practice.
[11] S. Kersten,et al. Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity. , 2014, Biochimica et biophysica acta.
[12] E. Lewandowski,et al. Dietary Fat Supply to Failing Hearts Determines Dynamic Lipid Signaling for Nuclear Receptor Activation and Oxidation of Stored Triglyceride , 2014, Circulation.
[13] Robert V Farese,et al. Cardiomyocyte-specific Loss of Diacylglycerol Acyltransferase 1 (DGAT1) Reproduces the Abnormalities in Lipids Found in Severe Heart Failure* , 2014, The Journal of Biological Chemistry.
[14] T. Haraguchi,et al. Deficiency of a Lipid Droplet Protein, Perilipin 5, Suppresses Myocardial Lipid Accumulation, Thereby Preventing Type 1 Diabetes-Induced Heart Malfunction , 2014, Molecular and Cellular Biology.
[15] A. Turkieh,et al. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. , 2014, The Journal of clinical investigation.
[16] Saptarsi M. Haldar,et al. Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism* , 2014, The Journal of Biological Chemistry.
[17] N. Lundbom,et al. Cardiac steatosis and left ventricular function in men with metabolic syndrome , 2013, Journal of Cardiovascular Magnetic Resonance.
[18] S. Ikuyama,et al. High glucose, insulin and free fatty acid concentrations synergistically enhance perilipin 3 expression and lipid accumulation in macrophages. , 2013, Metabolism: clinical and experimental.
[19] Stephanie J. Reisinger,et al. An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis , 2013, Science Translational Medicine.
[20] A. Hevener,et al. ERα regulates lipid metabolism in bone through ATGL and perilipin , 2013, Journal of cellular biochemistry.
[21] S. Homma,et al. Peroxisome Proliferator–Activated Receptor-&ggr; Activation Prevents Sepsis-Related Cardiac Dysfunction and Mortality In Mice , 2013, Circulation. Heart failure.
[22] N. Abumrad,et al. Perilipin 1 moves between the fat droplet and the endoplasmic reticulum , 2013, Adipocyte.
[23] Anup Mahurkar,et al. Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction1[S] , 2013, Journal of Lipid Research.
[24] D. Brasaemle. Perilipin 5: putting the brakes on lipolysis1 , 2013, Journal of Lipid Research.
[25] P. Schirmacher,et al. Adipophilin/perilipin‐2 as a lipid droplet‐specific marker for metabolically active cells and diseases associated with metabolic dysregulation , 2013, Histopathology.
[26] J. Dyck,et al. Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36 , 2012, Journal of Lipid Research.
[27] P. A. Wood,et al. Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity , 2012, Circulation.
[28] R. Synovec,et al. Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy , 2012, Circulation research.
[29] S. Homma,et al. Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice[S] , 2012, Journal of Lipid Research.
[30] Klitos Konstantinidis,et al. Mechanisms of cell death in heart disease. , 2012, Arteriosclerosis, thrombosis, and vascular biology.
[31] D. Mancini,et al. Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure , 2012, Circulation.
[32] P. Schulze,et al. Lipid metabolism and toxicity in the heart. , 2012, Cell metabolism.
[33] D. Mancini,et al. Adipose Tissue Inflammation and Adiponectin Resistance in Patients With Advanced Heart Failure: Correction After Ventricular Assist Device Implantation , 2012, Circulation. Heart failure.
[34] K. Otsu,et al. Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation*♦ , 2012, The Journal of Biological Chemistry.
[35] C. Sprung,et al. Diastolic dysfunction and mortality in severe sepsis and septic shock. , 2012, European heart journal.
[36] S. Grundy. Pre-diabetes, metabolic syndrome, and cardiovascular risk. , 2012, Journal of the American College of Cardiology.
[37] T. Shiomi,et al. Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor &ggr; Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias , 2011, Circulation.
[38] Petra C. Kienesberger,et al. Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction , 2011, Molecular and Cellular Biology.
[39] Hong Wang,et al. Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria[S] , 2011, Journal of Lipid Research.
[40] Ping Yang,et al. Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response , 2011, International journal of medical sciences.
[41] Petra C. Kienesberger,et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1 , 2011, Nature Medicine.
[42] S. Homma,et al. Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction* , 2011, The Journal of Biological Chemistry.
[43] D. Kelly,et al. Toll-like Receptor-mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated Receptor ␥ Coactivator-1 Signaling Clinical Perspective on P 482 Methods Animal Experiments and Generation Results Lps Stimulation Suppresses Cardiac Mitochondrial , 2022 .
[44] D. Clegg,et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. , 2011, The Journal of clinical investigation.
[45] W. Blaner,et al. DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S] , 2011, Journal of Lipid Research.
[46] W. Koch,et al. Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation. , 2011, American journal of physiology. Endocrinology and metabolism.
[47] K. Ocorr,et al. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. , 2011, Genes & development.
[48] M. Birnbaum,et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin , 2011, Nature Medicine.
[49] H. Watkins,et al. Inherited cardiomyopathies. , 2011, The New England journal of medicine.
[50] F. Thong,et al. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. , 2010, American journal of physiology. Endocrinology and metabolism.
[51] G. Shulman,et al. PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. , 2010, The Journal of clinical investigation.
[52] H. Bøtker,et al. Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function. , 2010, American journal of physiology. Heart and circulatory physiology.
[53] T. Costantino,et al. Current concepts in triglyceride metabolism, pathophysiology, and treatment. , 2010, Metabolism: clinical and experimental.
[54] S. Kersten,et al. Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor &bgr;/&dgr; and Protects Against Fatty Acid–Induced Oxidative Stress , 2010, Circulation research.
[55] J. Knuuti,et al. Metabolic imaging in myocardial ischemia and heart failure. , 2010, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....
[56] H. Taegtmeyer,et al. Return to the fetal gene program , 2010, Annals of the New York Academy of Sciences.
[57] I. Goldberg,et al. Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators , 2010, Circulation.
[58] C. Folmes,et al. Myocardial fatty acid metabolism in health and disease. , 2010, Physiological reviews.
[59] P. Schulze. Myocardial lipid accumulation and lipotoxicity in heart failure1 , 2009, Journal of Lipid Research.
[60] G. Paolisso,et al. Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome[S] , 2009, Journal of Lipid Research.
[61] Yu-gang Dong,et al. Adenosine monophosphate-activated protein kinase inhibits cardiac hypertrophy through reactivating peroxisome proliferator-activated receptor-alpha signaling pathway. , 2009, European journal of pharmacology.
[62] S. Hollenberg,et al. Cardiac dysfunction in severe sepsis and septic shock , 2009, Current opinion in critical care.
[63] J. Schaffer,et al. DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity* , 2009, The Journal of Biological Chemistry.
[64] K. Nair,et al. Paradoxical Coupling of Triglyceride Synthesis and Fatty Acid Oxidation in Skeletal Muscle Overexpressing DGAT1 , 2009, Diabetes.
[65] M. Bakovic,et al. The Development of a Metabolic Disease Phenotype in CTP:Phosphoethanolamine Cytidylyltransferase-deficient Mice* , 2009, The Journal of Biological Chemistry.
[66] T. Funahashi,et al. Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. , 2009, Surgery.
[67] H. Krum,et al. Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy , 2009, Circulation. Heart failure.
[68] J. Zierath,et al. Gain-of-function R225Q Mutation in AMP-activated Protein Kinase γ3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle* , 2008, Journal of Biological Chemistry.
[69] Jeroen J. Bax,et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. , 2008, Journal of the American College of Cardiology.
[70] L. Chan,et al. The PAT family of lipid droplet proteins in heart and vascular cells , 2008, Current hypertension reports.
[71] G. Piraino,et al. Ciglitazone ameliorates lung inflammation by modulating the inhibitor &kgr;B protein kinase/nuclear factor-&kgr;B pathway after hemorrhagic shock , 2008, Critical care medicine.
[72] S. Steinberg. Structural basis of protein kinase C isoform function. , 2008, Physiological reviews.
[73] Hanno Pijl,et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. , 2008, Journal of the American College of Cardiology.
[74] K. Airaksinen,et al. Trimetazidine, a Metabolic Modulator, Has Cardiac and Extracardiac Benefits in Idiopathic Dilated Cardiomyopathy , 2008, Circulation.
[75] H. Lamb,et al. Metabolic MRI of myocardial and hepatic triglyceride content in response to nutritional interventions , 2008, Current opinion in clinical nutrition and metabolic care.
[76] Jeroen J. Bax,et al. Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus. , 2008, American journal of physiology. Endocrinology and metabolism.
[77] V. Dilsizian,et al. Imaging myocardial metabolism and ischemic memory , 2008, Nature Clinical Practice Cardiovascular Medicine.
[78] H. Lamb,et al. Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function , 2008, Diabetes Care.
[79] J. Knuuti,et al. Myocardial fatty acid metabolism and cardiac performance in heart failure , 2008, Current cardiology reports.
[80] M. Isobe,et al. Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis , 2008, Intensive Care Medicine.
[81] E. Lewandowski,et al. The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover. , 2008, Journal of molecular and cellular cardiology.
[82] H. Lamb,et al. Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men. , 2008, The Journal of clinical endocrinology and metabolism.
[83] S. Wakil,et al. Reduced Heart Size and Increased Myocardial Fuel Substrate Oxidation in ACC2 Mutant Mice , 2007, American journal of physiology. Heart and circulatory physiology.
[84] J. Dyck,et al. CD36 Expression Contributes to Age-Induced Cardiomyopathy in Mice , 2007, Circulation.
[85] Jeroen J. Bax,et al. Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. , 2007, Radiology.
[86] Benjamin D. Levine,et al. Cardiac Steatosis in Diabetes Mellitus: A 1H-Magnetic Resonance Spectroscopy Study , 2007, Circulation.
[87] M. Merx,et al. Sepsis and the heart. , 2007, Circulation.
[88] P. D. de Tombe,et al. Augmented Protein Kinase C-α–Induced Myofilament Protein Phosphorylation Contributes to Myofilament Dysfunction in Experimental Congestive Heart Failure , 2007, Circulation research.
[89] E. Abel,et al. Diabetic cardiomyopathy revisited. , 2007, Circulation.
[90] Xianlin Han,et al. CD36 Deficiency Rescues Lipotoxic Cardiomyopathy , 2007, Circulation research.
[91] P. Tappia. Phospholipid-mediated signaling systems as novel targets for treatment of heart disease. , 2007, Canadian journal of physiology and pharmacology.
[92] Stefan Neubauer,et al. The failing heart--an engine out of fuel. , 2007, The New England journal of medicine.
[93] M. Birnbaum,et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. , 2007, Cell metabolism.
[94] S. Homma,et al. Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. , 2007, The Journal of clinical investigation.
[95] Xianlin Han,et al. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. , 2007, The Journal of clinical investigation.
[96] C. Kahn,et al. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. , 2007, The Journal of clinical investigation.
[97] P. Iozzo,et al. Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography , 2007, European Journal of Nuclear Medicine and Molecular Imaging.
[98] L. Peterson. Obesity and insulin resistance: Effects on cardiac structure, function, and substrate metabolism , 2006, Current hypertension reports.
[99] K. Petersen,et al. Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction , 2006, Diabetes.
[100] N. Wolins,et al. OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization , 2006, Diabetes.
[101] P. Rouet,et al. ApoO, a Novel Apolipoprotein, Is an Original Glycoprotein Up-regulated by Diabetes in Human Heart* , 2006, Journal of Biological Chemistry.
[102] K. Airaksinen,et al. Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure , 2006, Circulation.
[103] P. Iozzo,et al. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. , 2006, The Journal of clinical endocrinology and metabolism.
[104] P. Iozzo,et al. Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction. , 2006, Journal of cardiac failure.
[105] P. Ernsberger,et al. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. , 2006, American journal of physiology. Heart and circulatory physiology.
[106] J. Callés-Escandon,et al. Prolonged AMPK Activation Increases the Expression of Fatty Acid Transporters in Cardiac Myocytes and Perfused Hearts , 2006, Molecular and Cellular Biochemistry.
[107] E. Wagner,et al. Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase , 2006, Science.
[108] M. Zou,et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. , 2006, The Journal of clinical investigation.
[109] N. Alpert,et al. Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage. , 2006, American journal of physiology. Endocrinology and metabolism.
[110] J. McGill,et al. Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. , 2006, Journal of the American College of Cardiology.
[111] Min-Seon Kim,et al. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. , 2006, Biochemical and biophysical research communications.
[112] S. Souza,et al. Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin. , 2006, Molecular endocrinology.
[113] D. Severson,et al. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. , 2006, Diabetes.
[114] N. Borradaile,et al. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. , 2005, Molecular biology of the cell.
[115] Ping Wang,et al. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. , 2006, Critical care medicine.
[116] S. Mandrup,et al. Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation. , 2006, Journal of molecular endocrinology.
[117] Andrew N. Carr,et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. , 2006, Circulation.
[118] Jun Ren,et al. A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction? , 2006, Frontiers in bioscience : a journal and virtual library.
[119] B. Rothermel,et al. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. , 2005, Diabetes.
[120] R. Cooksey,et al. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. , 2005, Endocrinology.
[121] K. Clarke,et al. Metabolic Modulation With Perhexiline in Chronic Heart Failure: A Randomized, Controlled Trial of Short-Term Use of a Novel Treatment , 2005, Circulation.
[122] S. Yao,et al. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor γ, reduces pulmonary inflammatory response in a rat model of endotoxemia , 2005, Inflammation Research.
[123] J. Zierath,et al. Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle , 2005, Diabetologia.
[124] N. LeBrasseur,et al. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. , 2005, Biochemical and biophysical research communications.
[125] Yuan Zhang,et al. Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction. , 2005, Journal of molecular and cellular cardiology.
[126] S. Mudaliar,et al. Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists. , 2005, American journal of physiology. Endocrinology and metabolism.
[127] C. R. Wilson,et al. Metabolic Energetics and Genetics in the Heart , 2005, Annals of the New York Academy of Sciences.
[128] S. Summers,et al. Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling* , 2005, Journal of Biological Chemistry.
[129] B. Zingarelli,et al. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ IS A NEW THERAPEUTIC TARGET IN SEPSIS AND INFLAMMATION , 2005, Shock.
[130] A. Bonen,et al. Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats. , 2005, American journal of physiology. Heart and circulatory physiology.
[131] Xianlin Han,et al. Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy , 2005, Circulation research.
[132] J. Holloszy,et al. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. , 2005, Cell metabolism.
[133] J. Zierath,et al. Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. , 2005, Diabetes.
[134] G. Noon,et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[135] Michael D. Schneider,et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy , 2004, Nature Medicine.
[136] R. Cooksey,et al. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. , 2004, Diabetes.
[137] M. D. Turner. Fatty acyl CoA-mediated inhibition of endoplasmic reticulum assembly. , 2004, Biochimica et biophysica acta.
[138] C. Dence,et al. Effect of Obesity and Insulin Resistance on Myocardial Substrate Metabolism and Efficiency in Young Women , 2004, Circulation.
[139] L. Golfman,et al. Linking Gene Expression to Function: Metabolic Flexibility in the Normal and Diseased Heart , 2004, Annals of the New York Academy of Sciences.
[140] K. Feingold,et al. Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. , 2004, American journal of physiology. Endocrinology and metabolism.
[141] Lihong Cheng,et al. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. , 2004, Biochemical and biophysical research communications.
[142] G. Lopaschuk,et al. Energy Metabolism in the Hypertrophied Heart , 2002, Heart Failure Reviews.
[143] J. Sergiel,et al. Trimetazidine increases phosppholipid turnover in ventricular myocyte , 1997, Molecular and Cellular Biochemistry.
[144] S. Stratford. Regulation of insulin action by ceramide : dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase , 2004 .
[145] T. Hewett,et al. PKC-alpha regulates cardiac contractility and propensity toward heart failure. , 2004, Nature medicine.
[146] R. B. Rawson. The SREBP pathway — insights from insigs and insects , 2003, Nature Reviews Molecular Cell Biology.
[147] Kieran Clarke,et al. Abnormal Cardiac and Skeletal Muscle Energy Metabolism in Patients With Type 2 Diabetes , 2003, Circulation.
[148] N. Dhalla,et al. Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction. , 2003, American journal of physiology. Heart and circulatory physiology.
[149] Robert V Farese,et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[150] G. Metzger,et al. Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging , 2003, Magnetic resonance in medicine.
[151] I. Miyamori,et al. Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction. , 2003, Experimental and clinical cardiology.
[152] B. Strauer,et al. Alterations of left ventricular function in women with insulin-dependent diabetes mellitus during pregnancy , 2003, Diabetologia.
[153] D. Sawyer,et al. &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Cardiac Myocytes Is Mediated by Reactive Oxygen Species/c-Jun NH2-Terminal Kinase–Dependent Activation of the Mitochondrial Pathway , 2003, Circulation research.
[154] T. Jalili,et al. Increased translocation of cardiac protein kinase C beta2 accompanies mild cardiac hypertrophy in rats fed saturated fat. , 2003, The Journal of nutrition.
[155] S. Homma,et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. , 2003, The Journal of clinical investigation.
[156] Xianlin Han,et al. A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[157] R. Smolenski,et al. Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart. , 2003, Cellular & molecular biology letters.
[158] U. Smith,et al. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. , 2003, Biochemical and biophysical research communications.
[159] D. Levy,et al. Obesity and the risk of heart failure. , 2003, The New England journal of medicine.
[160] G. Shulman,et al. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.
[161] G. Shulman,et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[162] E. Herrera,et al. Increased reactive oxygen species production down-regulates peroxisome proliferator-activated a pathway in C2C12 skeletal muscle cells , 2002 .
[163] P. Iozzo,et al. Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. , 2002, Diabetes.
[164] Anand Kumar,et al. Clinical review: Myocardial depression in sepsis and septic shock , 2002, Critical care.
[165] B. Strauer,et al. Left Ventricular Diastolic Dysfunction as an Early Manifestation of Diabetic Cardiomyopathy , 2002, Cardiology.
[166] P. Razeghi,et al. Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. , 2002, Diabetes.
[167] J. Peters,et al. Pretreatment with troglitazone decreases lethality during endotoxemia in mice , 2002, Journal of endotoxin research.
[168] Alfred H. Merrill,et al. De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway* , 2002, The Journal of Biological Chemistry.
[169] Robert V Farese,et al. DGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption or Chylomicron Synthesis* , 2002, The Journal of Biological Chemistry.
[170] P. Kang,et al. Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes* , 2002, The Journal of Biological Chemistry.
[171] C. Kahn,et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. , 2002, The Journal of clinical investigation.
[172] Lee-Ming Chuang,et al. Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. , 2002, Diabetes care.
[173] L. Buja,et al. Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS. , 2002, American journal of physiology. Heart and circulatory physiology.
[174] Xianlin Han,et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. , 2002, The Journal of clinical investigation.
[175] M. Lorenzo,et al. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. , 2001, Diabetes.
[176] P. Young,et al. Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. , 2001, The Biochemical journal.
[177] Robert V Farese,et al. Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members* , 2001, The Journal of Biological Chemistry.
[178] P. Razeghi,et al. Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. , 2001, Biochemical and biophysical research communications.
[179] S. Eguchi,et al. Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells. , 2001, Cellular and molecular biology.
[180] Daniel S. Ory,et al. Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway* , 2001, The Journal of Biological Chemistry.
[181] M. Alpert. Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. , 2001, The American journal of the medical sciences.
[182] B. Monia,et al. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. , 2001, Molecular pharmacology.
[183] P. Herrero,et al. A novel mouse model of lipotoxic cardiomyopathy. , 2001, The Journal of clinical investigation.
[184] G. Shipley,et al. Uncoupling protein 3 transcription is regulated by peroxisome proliferator‐activated receptor α in the adult rodent heart , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[185] I. Batty,et al. Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells , 2001, Diabetologia.
[186] Y. Terauchi,et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. , 2001, The Journal of biological chemistry.
[187] J. McGarry,et al. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. , 2001, Diabetes.
[188] M. Bristow. Etomoxir: a new approach to treatment of chronic heart failure , 2000, The Lancet.
[189] D. Severson,et al. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice. , 2000, American journal of physiology. Endocrinology and metabolism.
[190] L. Buja,et al. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis. , 2000, American journal of physiology. Heart and circulatory physiology.
[191] Robert V Farese,et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat , 2000, Nature Genetics.
[192] L. Buja,et al. Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes. , 2000, Journal of molecular and cellular cardiology.
[193] G. Dohm,et al. Protein kinase C modulates insulin action in human skeletal muscle. , 2000, American journal of physiology. Endocrinology and metabolism.
[194] Rick B. Vega,et al. The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes , 2000, Molecular and Cellular Biology.
[195] L. Orci,et al. Lipotoxic heart disease in obese rats: implications for human obesity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[196] N. Yahagi,et al. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[197] D. Inthorn,et al. Hemofiltrate from patients with severe sepsis and depressed left ventricular contractility contains cardiotoxic compounds. , 1999, Shock.
[198] K. Feingold,et al. Down-regulation of liver and heart specific fatty acid binding proteins by endotoxin and cytokines in vivo. , 1999, Biochimica et biophysica acta.
[199] G. Lopaschuk,et al. Fatty acid oxidation in the reperfused ischemic heart. , 1999, The American journal of the medical sciences.
[200] R. Zechner,et al. Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[201] C. Newgard,et al. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. , 1998, The Journal of biological chemistry.
[202] Honglin Zhou,et al. Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide , 1998, Molecular and Cellular Biology.
[203] A. Newton,et al. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules. , 1998, Biochimica et biophysica acta.
[204] K. Feingold,et al. In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines. , 1998, American journal of physiology. Endocrinology and metabolism.
[205] P. Narayan,et al. Adenosine A1 receptor stimulation antagonizes the negative inotropic effects of the PKC activator dioctanoylglycerol. , 1998, Journal of molecular and cellular cardiology.
[206] R. Kolesnick,et al. Regulation of ceramide production and apoptosis. , 1998, Annual review of physiology.
[207] A. Ullrich,et al. Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). , 1998, Diabetologia.
[208] L. Ferrari,et al. Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes. , 1997, Biochemical pharmacology.
[209] W. Stoffel,et al. Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. , 1997, European journal of biochemistry.
[210] G. King,et al. Targeted overexpression of protein kinase C beta2 isoform in myocardium causes cardiomyopathy. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[211] G. Lopaschuk,et al. Upregulation of 5'-AMP-activated protein kinase is responsible for the increase in myocardial fatty acid oxidation rates following birth in the newborn rabbit. , 1997, Circulation research.
[212] J. Parrillo,et al. Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum , 1996, The Journal of experimental medicine.
[213] Y. Nishizuka. Protein kinase C and lipid signaling for sustained cellular responses , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[214] A. Haimovitz-Friedman,et al. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis , 1994, The Journal of experimental medicine.
[215] B. Spiegelman,et al. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. , 1994, Cell.
[216] D. Levy,et al. The epidemiology of heart failure: the Framingham Study. , 1993, Journal of the American College of Cardiology.
[217] G. King,et al. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[218] Y. Nishizuka. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. , 1992, Science.
[219] R. Jacob,et al. Metabolically-modulated growth and phenotype of the rat heart. , 1992, European heart journal.
[220] I. Goldberg,et al. Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV. , 1990, The Journal of biological chemistry.
[221] C. Natanson,et al. Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock , 1989, The Journal of experimental medicine.
[222] D. Janero,et al. Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists. , 1988, Biochemical pharmacology.
[223] M. Bennett,et al. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria. , 1987, Journal of lipid research.
[224] J. Kjekshus,et al. Importance of free fatty acids as a determinant of myocardial oxygen consumption and myocardial ischemic injury during norepinephrine infusion in dogs. , 1974, The Journal of clinical investigation.
[225] J. Hirvonen,et al. Triglycerides, cholesterol, and phospholipids in normal heart papillary muscle and in patients suffering from diabetes, cholelithiasis, hypertension, and coronary atheroma , 1973, Journal of clinical pathology.
[226] W. Kannel,et al. The natural history of congestive heart failure: the Framingham study. , 1971, The New England journal of medicine.
[227] E. C. Slater,et al. Uncoupling activity of long-chain fatty acids. , 1962, Biochimica et biophysica acta.
[228] H. M. Carpenter,et al. Myocardial fat infiltration. , 1962, American heart journal.
[229] P. Borst,et al. The oxidation of glutamate by rat-heart sarcosomes. , 1960, Biochimica et biophysica acta.
[230] R. Bing,et al. Myocardial metabolism of fatty acids. , 1960, The Journal of clinical investigation.
[231] R. Bing,et al. Metabolism of the Heart in Failure , 1960, Circulation.