Development of a fluorescent sensor for illicit date rape drug GHB.

The first fluorescent sensor (GHB Orange) for date rape drug GHB was developed. It exhibits the fluorescence quenching property for GHB and allows its detection in various drinks. The interaction mechanism was elucidated as intramolecular charge transfer induced by a hydrogen bond. This discovery will help in solving the drug facilitated sexual assault problems.

[1]  Y. Ishida,et al.  Disassembly-driven turn-on fluorescent nanoprobes for selective protein detection. , 2010, Journal of the American Chemical Society.

[2]  W. Kerns,et al.  Gamma hydroxybutyric acid (GHB) intoxication. , 2002, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[3]  R. Speich,et al.  Clinical features of gamma-hydroxybutyrate and gamma-butyrolactone toxicity and concomitant drug and alcohol use. , 2006, Drug and alcohol dependence.

[4]  Itaru Hamachi,et al.  Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging. , 2009, Nature chemistry.

[5]  G. Gessa,et al.  Dose-dependent absorption and elimination of gamma-hydroxybutyric acid in healthy volunteers , 2004, European Journal of Clinical Pharmacology.

[6]  H. Spiller,et al.  Drug‐Facilitated Sexual Assault Using Tetrahydrozoline , 2012, Journal of forensic sciences.

[7]  J. Lakowicz.  Principles of fluorescence spectroscopy , 1983 .

[8]  Marc Vendrell,et al.  Combinatorial strategies in fluorescent probe development. , 2012, Chemical reviews.

[9]  John D. Decatur,et al.  Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. , 2011, Forensic science international.

[10]  Marc Vendrell,et al.  Synthesis of a novel BODIPY library and its application in the discovery of a fructose sensor. , 2012, ACS combinatorial science.

[11]  L. Quang,et al.  Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature. , 2000, Pediatric emergency care.

[12]  R. Day,et al.  Extreme γ-butyrolactone overdose with severe metabolic acidosis requiring hemodialysis. , 2011, Annals of emergency medicine.

[13]  R. Schwartz,et al.  Drug-facilitated sexual assault ('date rape'). , 2000, Southern medical journal.

[14]  B. McCord,et al.  Micellar electrokinetic chromatographic screening method for common sexual assault drugs administered in beverages. , 2004, Forensic science international.

[15]  R. Palmer.  γ-Butyrolactone and 1,4-Butanediol , 2012 .

[16]  H. Sumnall,et al.  Use, function, and subjective experiences of gamma-hydroxybutyrate (GHB). , 2008, Drug and alcohol dependence.

[17]  K. Nicholson,et al.  GHB: a new and novel drug of abuse. , 2001, Drug and alcohol dependence.

[18]  Marc Vendrell,et al.  Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe. , 2009, Journal of the American Chemical Society.

[19]  Z. Demetrovics,et al.  Review: The involvement of gamma-hydroxybutyrate in reported sexual assaults: a systematic review , 2010, Journal of psychopharmacology.

[20]  A. Brailsford,et al.  Pharmacokinetic properties of γ-hydroxybutyrate (GHB) in whole blood, serum, and urine. , 2012, Journal of analytical toxicology.

[21]  Marc Vendrell,et al.  Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library. , 2011, Chemical communications.

[22]  Young‐Tae Chang,et al.  Diversity-oriented fluorescence library approach for the discovery of sensors and probes. , 2009, Molecular bioSystems.

[23]  Young‐Tae Chang,et al.  Diversity-oriented fluorescence library approaches for probe discovery and development. , 2010, Current opinion in chemical biology.

[24]  Itaru Hamachi,et al.  Specific cell surface protein imaging by extended self-assembling fluorescent turn-on nanoprobes. , 2012, Journal of the American Chemical Society.