Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score

Parkinson's disease (PD) is a highly age‐related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across all common variants may be clinically useful for individual risk stratification. A polygenic hazard score methodology, leveraging a time‐to‐event framework, has recently been successfully applied in other age‐related disorders.