Optimal experimental design for systems with bivariate failures under a bivariate Weibull function

type="main" xml:id="rssc12083-abs-0001"> In manufacturing industry, it may be important to study the relationship between machine component failures under stress. Examples include the failures of integrated circuits and memory chips in electronic merchandise given various levels of electronic shock. Such studies are important for the development of new products and for the improvement of existing products. We assume two-component systems for simplicity and we assume that the joint probability of failures increases with stress as a cumulative bivariate Weibull function. Optimal designs have been developed for two correlated binary responses by using the Gumbel model, the bivariate binary Cox model and the bivariate probit model. In all these models, the amount of damage ranges from −∞ to ∞. In the Weibull model, the amount of damage is positive, which is natural for experimental factors such as voltage, tension or pressure. We describe locally optimal designs under bivariate Weibull assumptions. Since locally optimal designs with non-linear models depend on predetermined parameter values, misspecified parameter values may lead to inefficient designs. However, we find that optimal designs under the Weibull model are surprisingly efficient over a wide range of misspecified parameter values. To improve the efficiency, we recommend a multistage procedure. We show how using a two-stage procedure can provide a substantial improvement over a design that was optimal for misspecified parameters.

[1]  N. Flournoy,et al.  Information in a two-stage adaptive optimal design , 2014 .

[2]  D. HanagalDavid A Bivariate Weibull Regression Model , 2005 .

[3]  William T. Scherer,et al.  "The desirability function: underlying assumptions and application implications" , 1998, SMC'98 Conference Proceedings. 1998 IEEE International Conference on Systems, Man, and Cybernetics (Cat. No.98CH36218).

[4]  Valerii V. Fedorov,et al.  Adaptive designs for selecting drug combinations based on efficacy–toxicity response , 2008 .

[5]  Optimal Designs for Contingent Response Models , 2004 .

[6]  W. J. Studden,et al.  Theory Of Optimal Experiments , 1972 .

[7]  L. Rüschendorf Construction of multivariate distributions with given marginals , 1985 .

[8]  Vladimir Dragalin,et al.  Two‐stage design for dose‐finding that accounts for both efficacy and safety , 2008, Statistics in medicine.

[9]  E. Gumbel Bivariate Exponential Distributions , 1960 .

[10]  Shaun S. Wang,et al.  “Understanding Relationships Using Copulas,” Edward Frees and Emiliano Valdez, January 1998 , 1999 .

[11]  Anthony C. Atkinson,et al.  Optimum Experimental Designs, with SAS , 2007 .

[12]  I. Olkin,et al.  Families of Multivariate Distributions , 1988 .

[13]  George E. P. Box,et al.  SEQUENTIAL DESIGN OF EXPERIMENTS FOR NONLINEAR MODELS. , 1963 .

[14]  L. White An extension of the General Equivalence Theorem to nonlinear models , 1973 .

[15]  J. Kiefer,et al.  The Equivalence of Two Extremum Problems , 1960, Canadian Journal of Mathematics.

[16]  L. Haines,et al.  Bayesian Optimal Designs for Phase I Clinical Trials , 2003, Biometrics.

[17]  V. Fedorov,et al.  Adaptive designs for dose-finding based on efficacy–toxicity response , 2006 .

[18]  H. Dette,et al.  On the efficiency of two‐stage response‐adaptive designs , 2013, Statistics in medicine.

[19]  J. Kiefer General Equivalence Theory for Optimum Designs (Approximate Theory) , 1974 .

[20]  Rupert G. Miller,et al.  Survival Analysis , 2022, The SAGE Encyclopedia of Research Design.

[21]  T. Ferguson A Course in Large Sample Theory , 1996 .

[22]  R. Nelsen An Introduction to Copulas , 1998 .

[23]  M. Fréchet Sur les tableaux de correlation dont les marges sont donnees , 1951 .

[24]  Steven E. Rigdon,et al.  Model-Oriented Design of Experiments , 1997, Technometrics.

[25]  Huwaida S. Rabie,et al.  Optimal designs for contingent response models with application to toxicity–efficacy studies , 2013 .

[26]  J. E. Freund A Bivariate Extension of the Exponential Distribution , 1961 .

[27]  I. Olkin,et al.  A Multivariate Exponential Distribution , 1967 .

[28]  V. Fedorov,et al.  Invited Discussion Paper Constrained Optimization of Experimental Design , 1995 .

[29]  M. Sklar Fonctions de repartition a n dimensions et leurs marges , 1959 .

[30]  Yuehui Wu,et al.  Dose Finding Designs for Continuous Responses and Binary Utility , 2007, Journal of biopharmaceutical statistics.

[31]  S. Silvey,et al.  A sequentially constructed design for estimating a nonlinear parametric function , 1980 .

[32]  L. Pronzato,et al.  Design of Experiments in Nonlinear Models: Asymptotic Normality, Optimality Criteria and Small-Sample Properties , 2013 .

[33]  Valerii V. Fedorov,et al.  Design of Experiments under Constraints , 1984 .