Recent Progress on Chemical Composition and Bioactivities of Bacopa monnieri ( Linn . ) a Plant of Ayurveda

Bacopa monnieri (Linn.) is a highly regarded medicinal plant in Indian traditional Ayurvedic medicine for centuries owing to its broad spectrum bioactivities. The biological effects of B. monnieri are documented in traditional as well as scientific literature. The plant possess many important bioactivities like memory enhancing, anti-oxidant, anti-inflammatory, analgesic, antipyretic, hepatoprotective, sedative, antiepileptic and still many more are constantly being discovered. An ample amount of research on B. monnieri and its major constituents has unraveled its tremendous bioactive potential in the treatment of many serious disorders viz. Alzheimer’s disease, cognitive functions, memory impairment, hepatic carcinoma and cigarette smoking-associated diseases. Since 2005, when the last review on B. monnieri was written, many more new bioactivities have been discovered, although they have not been compiled in one publication. In the present article we describe many new useful bioactivities of B. monnieri and its active chemical constituent bacoside and new chemical constituents that have been isolated and characterized. _____________________________________________________________________________________________________________

[1]  V. Vijayan,et al.  Efficacy of Bacopa monniera (L.) Wettst in Alleviating Lysosomal Instability in Adjuvant-Induced Arthritis in Rats , 2011, Inflammation.

[2]  A. Helen,et al.  Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst , 2011, Inflammopharmacology.

[3]  K. Rauf,et al.  Effect of Bacopasides on acquisition and expression of morphine tolerance. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[4]  Jagadish Singh,et al.  Antihyperglycemic Activity of Bacosine, a Triterpene from Bacopa monnieri, in Alloxan-Induced Diabetic Rats , 2010, Planta medica.

[5]  Ganesh Ambigapathy,et al.  Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. , 2011, Journal of ethnopharmacology.

[6]  Navneet Kumar,et al.  Effect of Bacopa monnieri on Cognitive functions in Alzheimer’s disease patients , 2011 .

[7]  Muralidhara,et al.  Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brain. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[8]  V. Gopalakrishnan,et al.  Potential Effect of Bacopa monnieri on Nitrobenzene Induced Liver Damage in Rats , 2010, Indian Journal of Clinical Biochemistry.

[9]  O. Wolkenhauer,et al.  Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans , 2010, Seizure.

[10]  I. Mohanty,et al.  Bacopa monniera protects rat heart against ischaemia–reperfusion injury: role of key apoptotic regulatory proteins and enzymes , 2010, The Journal of pharmacy and pharmacology.

[11]  M. Nandhu,et al.  Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieri. , 2010, Fitoterapia.

[12]  S. Kavitha,et al.  Bacopa monniera (L.) wettst inhibits type ii collagen‐induced arthritis in rats , 2010, Phytotherapy research : PTR.

[13]  S. Kavitha,et al.  Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells. , 2010, International immunopharmacology.

[14]  R. Sharath,et al.  Wound healing and protease inhibition activity of Bacoside‐A, isolated from Bacopa monnieri wettest , 2010, Phytotherapy research : PTR.

[15]  C. S. Paulose,et al.  Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A. , 2010, Journal of ethnopharmacology.

[16]  M. Nandhu,et al.  Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficits. , 2010, Fitoterapia.

[17]  D. Kong,et al.  Antitumor activities of dammarane triterpene saponins from Bacopa monniera , 2010, Phytotherapy research : PTR.

[18]  P. Janani,et al.  Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats , 2010, Journal of Cancer Research and Clinical Oncology.

[19]  A. Anand,et al.  Antiamnesic Effect of B. monniera on L-NNA Induced Amnesia Involves Calmodulin , 2010, Neurochemical Research.

[20]  C. S. Paulose,et al.  Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: Effect of Bacopa monnieri and bacoside A , 2010, Epilepsy & Behavior.

[21]  A. Anand,et al.  Scopolamine Induced Amnesia is Reversed by Bacopa monniera Through Participation of Kinase-CREB Pathway , 2010, Neurochemical Research.

[22]  K. Ingkaninan,et al.  Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. , 2010, Journal of ethnopharmacology.

[23]  K. Mahadik,et al.  Nootropic activity of lipid‐based extract of Bacopa monniera Linn. compared with traditional preparation and extracts , 2009 .

[24]  T. Sumathi,et al.  Effect of Bacopa monniera on liver and kidney toxicity in chronic use of opioids. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[25]  P. Janani,et al.  Hepatoprotective activity of bacoside A against N-nitrosodiethylamine-induced liver toxicity in adult rats , 2009, Cell Biology and Toxicology.

[26]  Neeraj Kumar,et al.  Dammarane triterpenoid saponins from Bacopa monnieri , 2009 .

[27]  D. Kong,et al.  A new triterpenoid saponin from Bacopa monniera , 2009 .

[28]  D. Prasad,et al.  Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment , 2009, Neurobiology of Disease.

[29]  D. Kong,et al.  Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice. , 2009, Planta medica.

[30]  P. Nathan,et al.  Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double‐blind placebo‐controlled randomized trial , 2008, Phytotherapy research : PTR.

[31]  C. Devi,et al.  Bacopa monniera extract Induces apoptosis in murine sarcoma cells (S‐180) , 2008, Phytotherapy research : PTR.

[32]  K. Ingkaninan,et al.  Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. , 2008, Journal of ethnopharmacology.

[33]  T. Sumathi,et al.  Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[34]  A. Anand,et al.  Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral–molecular partitioning , 2008, Neuroscience.

[35]  A. Helen,et al.  Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst. , 2008, Journal of ethnopharmacology.

[36]  M. Pillai,et al.  Effect of Bacopa monniera (Linn.) on lipid peroxidation and lipofuscinogenesis in prostate gland of D-galactose induced aging mice, Mus musculus. , 2008, Indian journal of experimental biology.

[37]  B. Manyam,et al.  Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera , 2007, Phytotherapy research : PTR.

[38]  Pallavi Sethi,et al.  Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain. , 2007, Journal of ethnopharmacology.

[39]  V. Vijayan,et al.  Protective activity of Bacopa monniera Linn. on nicotine‐induced toxicity in mice , 2007, Phytotherapy research : PTR.

[40]  Shabana I. Khan,et al.  Glycosides of 20-deoxy derivatives of jujubogenin and pseudojujubogenin from Bacopa monniera. , 2007, Planta medica.

[41]  K. Anbarasi,et al.  Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A , 2006, Neuroscience.

[42]  P. Dalal,et al.  Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment , 2006, Indian journal of psychiatry.

[43]  D. Knopman Current treatment of mild cognitive impairment and alzheimer’s disease , 2006, Current neurology and neuroscience reports.

[44]  Amar Jyoti,et al.  Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain. , 2006, Neurotoxicology.

[45]  M. Yaqoob,et al.  Anti-inflammatory activity of Bacopa monniera in rodents. , 2006, Journal of ethnopharmacology.

[46]  K. Anbarasi,et al.  Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. , 2006, Life sciences.

[47]  K. Anbarasi,et al.  Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of bacoside A. , 2005, Environmental toxicology and pharmacology.

[48]  K. Kishore,et al.  Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. , 2005, Indian journal of experimental biology.

[49]  F. Borrelli,et al.  Bacopa monniera, a reputed nootropic plant: an overview. , 2005, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[50]  P. Arivazhagan,et al.  Effect of DL-α-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats , 2002, Experimental Gerontology.

[51]  D. Prashanth,et al.  Mast cell stabilising activity of Bacopa monnieri. , 2001, Fitoterapia.

[52]  S. Pal,et al.  Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. , 2000, Journal of ethnopharmacology.

[53]  M. S. Dawre Medicinal plants of India , 1990 .

[54]  K. M. Nadkarni The Indian Materia Medica , 1927, The Indian Medical Gazette.

[55]  Radhika Kapoor,et al.  Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats. , 2009, Environmental toxicology and pharmacology.

[56]  B. Manyam,et al.  Bacopa monniera extract reduces amyloid levels in PSAPP mice. , 2006, Journal of Alzheimer's disease : JAD.

[57]  K. Anbarasi,et al.  Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of Bacoside A. , 2005, Vascular pharmacology.

[58]  A. Amit,et al.  The need for establishing identities of 'bacoside A and B', the putative major bioactive saponins of Indian medicinal plant Bacopa monnieri. , 2004, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[59]  G. Glenner,et al.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.

[60]  R. Chopra Supplement to Glossary of Indian Medicinal Plants , 1969 .