Strength of immune selection in tumors varies with sex and age

[1]  G. Mills,et al.  Sex-associated molecular differences for cancer immunotherapy , 2020, Nature Communications.

[2]  D. Lang,et al.  Differences in tumor initiation and progression of melanoma in the BrafCA;Tyr‐CreERT2;Ptenf/f model between male and female mice , 2020, Pigment cell & melanoma research.

[3]  P. Bousso,et al.  The immune system profoundly restricts intratumor genetic heterogeneity , 2018, Science Immunology.

[4]  Hannah Carter,et al.  Evolutionary Pressure against MHC Class II Binding Cancer Mutations , 2018, Cell.

[5]  J. Greenbaum,et al.  Improved methods for predicting peptide binding affinity to MHC class II molecules , 2018, Immunology.

[6]  Huiqun Wu,et al.  Correlation between sex and efficacy of immune checkpoint inhibitors (PD‐1 and CTLA‐4 inhibitors) , 2018, International journal of cancer.

[7]  Stephen M. Douglass,et al.  Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations , 2018, Clinical Cancer Research.

[8]  Jedd D. Wolchok,et al.  Cancer immunotherapy using checkpoint blockade , 2018, Science.

[9]  Michael C. Heinold,et al.  The landscape of genomic alterations across childhood cancers , 2018, Nature.

[10]  Dennis Görlich,et al.  Sex bias in MHC I-associated shaping of the adaptive immune system , 2018, Proceedings of the National Academy of Sciences.

[11]  Junqian Zhang,et al.  Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade , 2018, eLife.

[12]  T. Ideker,et al.  MHC-I Genotype Restricts the Oncogenic Mutational Landscape , 2017, Cell.

[13]  L. Strigari,et al.  The sexist behaviour of immune checkpoint inhibitors in cancer therapy? , 2017, Oncotarget.

[14]  M. Nielsen,et al.  NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data , 2017, The Journal of Immunology.

[15]  R. Yamada,et al.  HLA‐HD: An accurate HLA typing algorithm for next‐generation sequencing data , 2017, Human mutation.

[16]  E. Kirkness,et al.  Fast and accurate HLA typing from short-read next-generation sequence data with xHLA , 2017, Proceedings of the National Academy of Sciences.

[17]  Morten Nielsen,et al.  NetMHCpan 4.0: Improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data , 2017, bioRxiv.

[18]  R. Dummer,et al.  Evaluation of clinicopathological factors in PD-1 response: derivation and validation of a prediction scale for response to PD-1 monotherapy , 2017, British Journal of Cancer.

[19]  S. Hodge,et al.  How Can We Explain Very Low Odds Ratios in GWAS? I. Polygenic Models , 2017, Human Heredity.

[20]  S. Klein,et al.  Sex differences in immune responses , 2016, Nature Reviews Immunology.

[21]  M. Nielsen,et al.  NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets , 2016, Genome Medicine.

[22]  Nicolai J. Birkbak,et al.  Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade , 2016, Science.

[23]  A. McMichael,et al.  Evolution of the immune system in humans from infancy to old age , 2015, Proceedings of the Royal Society B: Biological Sciences.

[24]  M. Stratton,et al.  Clock-like mutational processes in human somatic cells , 2015, Nature Genetics.

[25]  K. Cibulskis,et al.  Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes , 2015, Nature Biotechnology.

[26]  Mary M. Cavanagh,et al.  Naive T Cell Maintenance and Function in Human Aging , 2015, The Journal of Immunology.

[27]  Steven J. M. Jones,et al.  Integrated Genomic Characterization of Papillary Thyroid Carcinoma , 2014, Cell.

[28]  S. Elledge,et al.  Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome , 2013, Cell.

[29]  David T. W. Jones,et al.  Signatures of mutational processes in human cancer , 2013, Nature.

[30]  O. Lund,et al.  NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ , 2013, Immunogenetics.

[31]  Mark M. Davis,et al.  Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination , 2013, Science Translational Medicine.

[32]  M. Stratton,et al.  Deciphering Signatures of Mutational Processes Operative in Human Cancer , 2013, Cell reports.

[33]  M. Abdullah,et al.  Gender effect on in vitro lymphocyte subset levels of healthy individuals. , 2012, Cellular immunology.

[34]  Syed Haider,et al.  International Cancer Genome Consortium Data Portal—a one-stop shop for cancer genomics data , 2011, Database J. Biol. Databases Curation.

[35]  Hannah Carter,et al.  CHASM and SNVBox: toolkit for detecting biologically important single nucleotide mutations in cancer , 2011, Bioinform..

[36]  R. Schreiber,et al.  Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion , 2011, Science.

[37]  Hideaki Sugawara,et al.  The Sequence Read Archive , 2010, Nucleic Acids Res..

[38]  Z. Barta,et al.  Sexual dimorphism in immune function changes during the annual cycle in house sparrows , 2010, Naturwissenschaften.

[39]  A. Clark,et al.  X-Linked Variation in Immune Response in Drosophila melanogaster , 2009, Genetics.

[40]  W. Carr,et al.  Half- vs full-dose trivalent inactivated influenza vaccine (2004-2005): age, dose, and sex effects on immune responses. , 2008, Archives of internal medicine.

[41]  Sudhir Gupta,et al.  Dendritic cells in human aging , 2007, Experimental Gerontology.

[42]  R. Schreiber,et al.  Cancer immunoediting: from immunosurveillance to tumor escape , 2002, Nature Immunology.

[43]  M. Croft,et al.  Functional cooperation between T helper cell determinants. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Hodes,et al.  Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with Age , 2000, The Journal of Immunology.

[45]  U. Rai,et al.  Sexual dimorphism in phagocytic activity of wall lizard's splenic macrophages and its control by sex steroids. , 1999, General and comparative endocrinology.

[46]  S J Gange,et al.  Epidemiology and estimated population burden of selected autoimmune diseases in the United States. , 1997, Clinical immunology and immunopathology.

[47]  G. Danieli,et al.  Genetic control of the CD4/CD8 T-cell ratio in humans , 1995, Nature Medicine.

[48]  J. Forman,et al.  Helper activity is required for the in vivo generation of cytotoxic T lymphocytes , 1982, The Journal of experimental medicine.

[49]  F. Burnet.  The concept of immunological surveillance. , 1970, Progress in experimental tumor research.