HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

[1]  Xiaoying Wang,et al.  HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation‐induced transendothelial permeability by elevating PPARγ activity in vitro , 2018, Journal of neurochemistry.

[2]  M. Lazar,et al.  Integrative regulation of physiology by histone deacetylase 3 , 2018, Nature Reviews Molecular Cell Biology.

[3]  V. Mohan,et al.  Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes , 2018, Human genomics.

[4]  L. Cai,et al.  HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection. , 2018, American journal of physiology. Endocrinology and metabolism.

[5]  E. Lo,et al.  Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice , 2018, Molecular Neurobiology.

[6]  Xiaofen Xu,et al.  Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses , 2018, Journal of neuroinflammation.

[7]  Jian Xiao,et al.  bFGF Protects Against Oxygen Glucose Deprivation/Reoxygenation-Induced Endothelial Monolayer Permeability via S1PR1-Dependent Mechanisms , 2017, Molecular Neurobiology.

[8]  P. Scheltens,et al.  CSF ApoE predicts clinical progression in nondemented APOEε4 carriers , 2017, Neurobiology of Aging.

[9]  Piul S. Rabbani,et al.  The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus , 2017, Journal of diabetes research.

[10]  L. Cucullo,et al.  Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10? , 2017, Neuroscience Letters.

[11]  Shizhong Zheng,et al.  Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway , 2017, Journal of Neuroinflammation.

[12]  Y. Persidsky,et al.  Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition , 2017, Journal of Neuroimmune Pharmacology.

[13]  B. Ju,et al.  Dexamethasone suppresses JMJD3 gene activation via a putative negative glucocorticoid response element and maintains integrity of tight junctions in brain microvascular endothelial cells , 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  Zengqiang Yuan,et al.  Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia , 2017, Neural plasticity.

[15]  Min Jung Park,et al.  The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats , 2016, Journal of Neuroinflammation.

[16]  Linyin Feng,et al.  Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats , 2016, Front. Mol. Neurosci..

[17]  V. Mohan,et al.  Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes , 2016, Clinical Epigenetics.

[18]  E. Lo,et al.  Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. , 2016, Journal of neurotrauma.

[19]  G. Hardingham,et al.  Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes , 2016, Free radical biology & medicine.

[20]  Tetsuji Yamamoto,et al.  Albumin microvascular leakage in brains with diabetes mellitus , 2016, Microscopy research and technique.

[21]  B. Baban,et al.  Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice , 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  D. Yoo,et al.  Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus , 2016, The Journal of veterinary medical science.

[23]  David R Webb,et al.  Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective , 2015, Postgraduate Medical Journal.

[24]  Zhen Zhao,et al.  Establishment and Dysfunction of the Blood-Brain Barrier , 2015, Cell.

[25]  A. Dinkova-Kostova,et al.  The emerging role of Nrf2 in mitochondrial function , 2015, Free radical biology & medicine.

[26]  S. Poulsen,et al.  Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats , 2015, Diabetes, obesity & metabolism.

[27]  L. Cucullo,et al.  Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro , 2015, PloS one.

[28]  Yu Cao,et al.  Cell-Culture Models of the Blood–Brain Barrier , 2014, Stroke.

[29]  I. Wilhelm,et al.  In vitro models of the blood-brain barrier for the study of drug delivery to the brain. , 2014, Molecular pharmaceutics.

[30]  U. Bayraktutan,et al.  Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C‐β , 2013, Diabetes, obesity & metabolism.

[31]  L. Marton,et al.  Histone Deacetylase Inhibition Overcomes Drug Resistance through a miRNA-Dependent Mechanism , 2013, Molecular Cancer Therapeutics.

[32]  G. Rogge,et al.  HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner , 2013, Proceedings of the National Academy of Sciences.

[33]  G. Natoli,et al.  Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages , 2012, Proceedings of the National Academy of Sciences.

[34]  S. Schreiber,et al.  Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. , 2012, Chemistry & biology.

[35]  M. Mogi,et al.  Peroxisome Proliferator-Activated Receptor-&ggr; Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice , 2012, Hypertension.

[36]  M. Alcaraz,et al.  Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts. , 2012, Biochemical pharmacology.

[37]  M. Modo,et al.  Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke , 2011, The Journal of physiology.

[38]  Masayuki Yamamoto,et al.  Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution , 2011, Genes to cells : devoted to molecular & cellular mechanisms.

[39]  S. Cazaubon,et al.  The blood-brain barrier in brain homeostasis and neurological diseases. , 2009, Biochimica et biophysica acta.

[40]  Eric V Shusta,et al.  In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[41]  C. Vannini,et al.  Structural organization of the tight junctions. , 2008, Biochimica et biophysica acta.

[42]  Jing Zhao,et al.  Enhancing Expression of Nrf2-Driven Genes Protects the Blood–Brain Barrier after Brain Injury , 2007, The Journal of Neuroscience.

[43]  A. R. Kulkarni,et al.  Targeted nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[44]  T. Davis,et al.  The Blood-Brain Barrier/Neurovascular Unit in Health and Disease , 2005, Pharmacological Reviews.

[45]  S. Citi,et al.  Histone deacetylase inhibitors up-regulate the expression of tight junction proteins. , 2004, Molecular cancer research : MCR.

[46]  D. Antonetti,et al.  Regulation of tight junctions and loss of barrier function in pathophysiology. , 2004, The international journal of biochemistry & cell biology.

[47]  A. V. van Kuilenburg,et al.  Histone deacetylases (HDACs): characterization of the classical HDAC family. , 2003, The Biochemical journal.

[48]  C. Allis,et al.  The language of covalent histone modifications , 2000, Nature.

[49]  M. Kaya,et al.  Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase. , 2011, Methods in molecular biology.

[50]  S. Nag.  Morphology and properties of astrocytes. , 2011, Methods in molecular biology.

[51]  F. Bloom,et al.  Distribution of histone deacetylases 1–11 in the rat brain , 2007, Journal of Molecular Neuroscience.