Passage of Molecules Through Capillary Walk

antipyrine derivatives were found to be related to the temperature coefficients of their lipid solubilities rather than to their aqueous diffusion coefficients. These results indicate that lipid-soluble molecules can diffuse through regions in the capillary wall which are relatively impermeable to lipid-insoluble molecules. The permeability characteristics of this additional pathway are similar to those of cell membranes in general. It seems reasonable, therefore, to identify the diffusion pathway for lipid-soluble molecules with the plasma membranes of the capillary endothelia! cells themselves, as opposed to the system of water-filled pores penetrating through or between these cells, which is capable of accounting for the pas- sage of water and lipid-insoluble molecules.

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