Multivalent foldamer-based affinity assay for selective recognition of Aβ oligomers.

[1]  Arti Vashist,et al.  Nano-biosensors to detect beta-amyloid for Alzheimer's disease management. , 2016, Biosensors & bioelectronics.

[2]  L. Tan,et al.  The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease , 2016, Molecular Neurobiology.

[3]  B. Sutton,et al.  Antibody mimetics: promising complementary agents to animal-sourced antibodies , 2016, Critical reviews in biotechnology.

[4]  Lin Liu,et al.  Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling , 2015 .

[5]  D. Manahan‐Vaughan,et al.  Acute intracerebral treatment with amyloid-beta (1–42) alters the profile of neuronal oscillations that accompany LTP induction and results in impaired LTP in freely behaving rats , 2015, Front. Behav. Neurosci..

[6]  K. Blennow,et al.  Amyloid biomarkers in Alzheimer's disease. , 2015, Trends in pharmacological sciences.

[7]  A. Saghatelian,et al.  A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo , 2014, Journal of the American Chemical Society.

[8]  N. Hooper,et al.  A label-free electrical impedimetric biosensor for the specific detection of Alzheimer's amyloid-beta oligomers. , 2014, Biosensors & bioelectronics.

[9]  S. Gellman,et al.  Backbone modification of a polypeptide drug alters duration of action in vivo , 2014, Nature Biotechnology.

[10]  Nan Li,et al.  Electrochemical immunosensors for effective evaluation of amyloid-beta modulators on oligomeric and fibrillar aggregation processes. , 2014, Analytical chemistry.

[11]  G. Juhász,et al.  A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers , 2012, PloS one.

[12]  D. Eisenberg,et al.  Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity , 2012, Nature Chemistry.

[13]  S. Gellman,et al.  Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling. , 2012, Journal of the American Chemical Society.

[14]  F. Fülöp,et al.  Peptidic foldamers: ramping up diversity. , 2012, Chemical Society reviews.

[15]  K. Blennow,et al.  Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease , 2010, PloS one.

[16]  P. Magistretti,et al.  Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species* , 2010, The Journal of Biological Chemistry.

[17]  Dag Sehlin,et al.  Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease , 2010, BMC Neuroscience.

[18]  T. Tokuda,et al.  High-molecular weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients , 2010, Alzheimer's & Dementia.

[19]  Ernest Giralt,et al.  Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange. , 2010, Accounts of chemical research.

[20]  Christian Bailly,et al.  Strategies and challenges for the next generation of therapeutic antibodies , 2010, Nature Reviews Immunology.

[21]  Arjel D. Bautista,et al.  Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells. , 2009, Bioorganic & medicinal chemistry letters.

[22]  Erinna F. Lee,et al.  High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. , 2009, Angewandte Chemie.

[23]  T. Iwatsubo,et al.  Inhibition of gamma-secretase activity by helical beta-peptide foldamers. , 2009, Journal of the American Chemical Society.

[24]  H. Fukuyama,et al.  Peripheral Aβ subspecies as risk biomarkers of Alzheimer's disease , 2008, Proceedings of the National Academy of Sciences.

[25]  D. Riesner,et al.  An ultrasensitive assay for diagnosis of Alzheimer's disease. , 2008, Rejuvenation research.

[26]  W Seth Horne,et al.  Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains. , 2008, Angewandte Chemie.

[27]  D. Riesner,et al.  Single particle detection of Abeta aggregates associated with Alzheimer's disease. , 2007, Biochemical and biophysical research communications.

[28]  Dag Sehlin,et al.  Sensitive ELISA detection of amyloid‐β protofibrils in biological samples , 2007 .

[29]  A. Hamilton,et al.  Foldamer‐based Molecular Recognition , 2007 .

[30]  Scott J. Shandler,et al.  Foldamers as versatile frameworks for the design and evolution of function. , 2007, Nature chemical biology.

[31]  P. Lewczuk,et al.  Immune complexes of auto-antibodies against Aβ1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients , 2007, Molecular Psychiatry.

[32]  P. Hudson,et al.  Engineered antibody fragments and the rise of single domains , 2005, Nature Biotechnology.

[33]  C. Mirkin,et al.  Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  R. V. Van Duyne,et al.  Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. , 2005, Journal of the American Chemical Society.

[35]  Joshua A. Kritzer,et al.  Helical β-Peptide Inhibitors of the p53-hDM2 Interaction , 2004 .

[36]  D. Hoyer,et al.  Synthesis and Biological Evaluation of a Cyclo-β-tetrapeptide as a Somatostatin Analogue. , 1999, Angewandte Chemie.

[37]  D. Riesner,et al.  Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy , 1998, Nature Medicine.

[38]  A. Besmehn,et al.  The amyloid-β oligomer count in cerebrospinal fluid is a biomarker for Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.

[39]  K. Blennow,et al.  Amyloid-β oligomers in cerebrospinal fluid are associated with cognitive decline in patients with Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.

[40]  D. Eisenberg,et al.  Amyloid -sheet mimics that antagonize protein aggregation and reduce amyloid toxicity , 2012 .

[41]  Ivan Huc,et al.  Synthetic foldamers. , 2011, Chemical communications.

[42]  P. Magistretti,et al.  A42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete , 2011 .

[43]  K. Blennow,et al.  A beta 40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer ' s Disease , 2010 .

[44]  L. Lannfelt,et al.  Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. , 2007, Journal of neurochemistry.

[45]  H. Wiśniewski,et al.  Plasma and cerebrospinal fluid Levels of amyloid β proteins 1-40 and 1-42 in Alzheimer disease , 2000 .