Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma
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G. O'Neill | K. McDonald | T. Johns | D. Gough | B. Stringer | C. Mitchell | B. Day | Y. Lim | S. Greenall | A. Wilding | K. S. Ensbey | Kathleen S. Ensbey | Alexander L. Wilding | Camilla B. Mitchell
[1] G. O'Neill,et al. Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification , 2017, Cell adhesion & migration.
[2] Maribel Vazquez,et al. In vitro formation of neuroclusters in microfluidic devices and cell migration as a function of stromal-derived growth factor 1 gradients , 2017, Cell adhesion & migration.
[3] Matthew Grist,et al. Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity , 2016, Clinical Cancer Research.
[4] M. Ramachandra,et al. Abstract 3070: Potent and selective inhibition of CDK7 by novel covalent inhibitors , 2016 .
[5] Ming-Rong Wang,et al. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma , 2016, Gut.
[6] Kedar S Vaidya,et al. ABT-414, an Antibody–Drug Conjugate Targeting a Tumor-Selective EGFR Epitope , 2016, Molecular Cancer Therapeutics.
[7] In-Hee Lee,et al. Spatiotemporal Evolution of the Primary Glioblastoma Genome. , 2015, Cancer cell.
[8] R. Young,et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer , 2015, Cell.
[9] J. Donoghue,et al. EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications , 2015, Oncogene.
[10] Gary D Bader,et al. Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity , 2015, Proceedings of the National Academy of Sciences.
[11] J. Bradner,et al. Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor. , 2014, Cancer cell.
[12] Howard Y. Chang,et al. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing , 2014, Nature.
[13] A. Sandelin,et al. Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes , 2014, Genes & development.
[14] Bandana Sharma,et al. CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer , 2014, Cell.
[15] T. Albert,et al. Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells , 2014, Molecular and Cellular Biology.
[16] Gary D Bader,et al. SINGLE CELL DERIVED CLONAL ANALYSIS OF HUMAN GLIOBLASTOMA LINKS FUNCTIONAL AND GENOMIC HETEROGENEITY , 2014, Neuro-Oncology.
[17] J. C. Love,et al. EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing. , 2014, Cancer discovery.
[18] Sridhar Ramaswamy,et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor , 2014, Nature.
[19] Shawn M. Gillespie,et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma , 2014, Science.
[20] N. Gottardo,et al. Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo. , 2014, Oncogene.
[21] Amaia Agirre,et al. A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. , 2014, Neuro-oncology.
[22] D. Haussler,et al. The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.
[23] P. Mischel,et al. De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients. , 2013, Cancer discovery.
[24] V. P. Collins,et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics , 2013, Proceedings of the National Academy of Sciences.
[25] Chao Zhang,et al. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II , 2012, Nature Structural &Molecular Biology.
[26] N. Watkins,et al. Nucleolar disruption leads to the spatial separation of key 18S rRNA processing factors , 2012, RNA biology.
[27] Rebecca A Betensky,et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. , 2011, Cancer cell.
[28] A. Scott,et al. Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation , 2011, Cancers.
[29] R. Russell,et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. , 2009, Cell stem cell.
[30] G. Morris,et al. The Cajal body. , 2008, Biochimica et biophysica acta.
[31] S. Leenstra,et al. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids , 2008, Oncogene.
[32] M. Hagiwara,et al. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA , 2007, Nature Chemical Biology.
[33] R. Terns,et al. Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs , 2007, Nature Reviews Molecular Cell Biology.
[34] P. Caroni,et al. Preparation of organotypic hippocampal slice cultures for long-term live imaging , 2006, Nature Protocols.
[35] Yuri Kotliarov,et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. , 2006, Cancer cell.
[36] Tamás Kiss,et al. Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm , 2003, The EMBO journal.
[37] Ruedi Aebersold,et al. Molecular characterization of mitochondrial apoptosis-inducing factor , 1999, Nature.
[38] D C Ward,et al. Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains. , 1996, Experimental cell research.
[39] R. Kobayashi,et al. Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. , 1995, Cancer research.
[40] David O. Morgan,et al. A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase , 1994, Cell.
[41] Gordon K Smyth,et al. Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .