Weak immunohistochemical expression of galectin‐3 near blisters in Hailey‐Hailey disease

Hailey‐Hailey disease (HHD) is an uncommon hereditary and benign skin condition characterized by blisters and erosions on intertriginous areas. It is related to a mutation of the ATP2C1 gene, which encodes a Ca2+ pump. It is characterized by multiple foci of skin acantholysis in the epidermis, with dyskeratosis and suprabasilar clefting. Galectin‐3 is a beta‐galactoside‐binding protein that has an essential role in cell‐to‐cell and cell‐to‐matrix adhesion. We assessed galectin‐3 immunohistochemical expression in HHD to explore its impact on the pathogenesis of this hereditary blistering disorder.

[1]  B. Smoller,et al.  Immunohistochemical Expression of Galectin-3 in Pemphigus Vulgaris , 2021, The American Journal of dermatopathology.

[2]  B. Smoller,et al.  Diminished Expression of Galectin-3 Around Blisters in Bullous Pemphigoid: An Immunohistochemistry Study , 2020, Dermatology practical & conceptual.

[3]  D. Hamilton,et al.  Galectin-3 regulation of wound healing and fibrotic processes: insights for chronic skin wound therapeutics , 2018, Journal of Cell Communication and Signaling.

[4]  M. Mizawa,et al.  A novel deletion mutation of the ATP2C1 gene in a family with Hailey-Hailey disease , 2016, European Journal of Dermatology.

[5]  S. Andreadis,et al.  CDH2 and CDH11 act as regulators of stem cell fate decisions. , 2015, Stem cell research.

[6]  Y. Uchino,et al.  Galectin-3 as a regulator of the epithelial junction: Implications to wound repair and cancer , 2015, Tissue barriers.

[7]  Ming Xin,et al.  Role of the interaction between galectin-3 and cell adhesion molecules in cancer metastasis. , 2015, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  S. Stowell,et al.  Galectin-3 Regulates Desmoglein-2 and Intestinal Epithelial Intercellular Adhesion* , 2014, The Journal of Biological Chemistry.

[9]  H. Bikker,et al.  Mechanistic Basis of Desmosome-Targeted Diseases , 2013, Journal of molecular biology.

[10]  T. Cropley,et al.  What's in a name?: Hailey-Hailey disease. , 2013, JAMA dermatology.

[11]  D. Hsu,et al.  Galectins and cutaneous immunity , 2012 .

[12]  Fu-Tong Liu,et al.  Galectin-3 and the skin. , 2011, Journal of dermatological science.

[13]  S. Peltonen,et al.  Tight junctions in Hailey-Hailey and Darier's diseases , 2009, Dermatology reports.

[14]  A. Kowalczyk,et al.  The desmosome. , 2009, Cold Spring Harbor perspectives in biology.

[15]  W. Dong,et al.  Li-cadherin is Inversely Correlated with Galectin-3 Expression in Gastric Cancer , 2008, Digestive Diseases and Sciences.

[16]  L. Gan,et al.  [Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer]. , 2007, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[17]  L. Godsel,et al.  Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. , 2007, Journal of dermatological science.

[18]  Mirna Flögel,et al.  Galectin-3: an open-ended story. , 2006, Biochimica et biophysica acta.

[19]  J. Hunyadi,et al.  Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases. , 2004, Acta dermato-venereologica.

[20]  S. Hirohashi,et al.  Expression of liver‐intestine cadherin and its possible interaction with galectin‐3 in ductal adenocarcinoma of the pancreas , 2003, Cancer science.

[21]  A. Merritt,et al.  Desmosomal cadherins. , 2002, Current opinion in cell biology.

[22]  M. Akiyama,et al.  Upregulation of P‐cadherin expression in the lesional skin of pemphigus, Hailey‐Hailey disease and Darier’s disease , 2001, Journal of cutaneous pathology.

[23]  M. Akiyama,et al.  Dissociation of intra‐ and extracellular domainsof desmosomal cadherins and E‐cadherin inHailey–Hailey disease and Darier’s disease , 2000, The British journal of dermatology.

[24]  K. Toda,et al.  Roles of E‐ and P‐cadherin in the human skin , 1997, Microscopy research and technique.