CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse

[1]  L. Hendershot,et al.  CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. , 2010, Molecular immunology.

[2]  C. Stehouwer,et al.  Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? , 2009, Apoptosis.

[3]  C. Godson,et al.  Diabetes mellitus and apoptosis: inflammatory cells , 2009, Apoptosis.

[4]  H. Thomas,et al.  Beta cell apoptosis in diabetes , 2009, Apoptosis.

[5]  M. Mori,et al.  The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis. , 2008, Metabolism: clinical and experimental.

[6]  D. R. Laybutt,et al.  Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling , 2008, Diabetes.

[7]  Subramaniam Pennathur,et al.  Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. , 2008, The Journal of clinical investigation.

[8]  R. Rizza,et al.  High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes , 2007, Diabetes.

[9]  P. Walter,et al.  Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.

[10]  J. Kench,et al.  Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes , 2007, Diabetologia.

[11]  R. Rizza,et al.  Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans , 2006, Diabetologia.

[12]  A. Volchuk,et al.  Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. , 2006, Endocrinology.

[13]  R. Kaufman,et al.  From acute ER stress to physiological roles of the Unfolded Protein Response , 2006, Cell Death and Differentiation.

[14]  Nils Welsh,et al.  Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. , 2005, Diabetes.

[15]  R. Rizza,et al.  Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? , 2005, Diabetologia.

[16]  J. Chae,et al.  Involvement of GADD153 and Cardiac Ankyrin Repeat Protein in Hypoxia-induced Apoptosis of H9c2 Cells* , 2005, Journal of Biological Chemistry.

[17]  D. Neuberg,et al.  Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  F. Ortis,et al.  Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. , 2005, Diabetes.

[19]  Christopher J. Rhodes,et al.  Type 2 Diabetes-a Matter of ß-Cell Life and Death? , 2005, Science.

[20]  C. Rhodes Type 2 diabetes-a matter of beta-cell life and death? , 2005, Science.

[21]  M. Cnop,et al.  Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress , 2004 .

[22]  U. Boggi,et al.  Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. , 2004, The Journal of clinical endocrinology and metabolism.

[23]  L. Glimcher,et al.  Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.

[24]  I. Chang,et al.  Death effectors of β-cell apoptosis in type 1 diabetes , 2004 .

[25]  M. Czech,et al.  An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. , 2004, Genes & development.

[26]  S. Oyadomari,et al.  Roles of CHOP/GADD153 in endoplasmic reticulum stress , 2004, Cell Death and Differentiation.

[27]  W. Suarez-Pinzon,et al.  Role of Cytokines in the Pathogenesis of Autoimmune Diabetes Mellitus , 2003, Reviews in Endocrine and Metabolic Disorders.

[28]  E. Araki,et al.  Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells , 2002, Apoptosis.

[29]  N. Welsh,et al.  The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells , 1996, Diabetologia.

[30]  Y. Matsuzawa,et al.  Cytokine-induced apoptotic cell death in a mouse pancreatic beta-cell line: inhibition by Bcl-2 , 1996, Diabetologia.

[31]  I. Chang,et al.  Death effectors of beta-cell apoptosis in type 1 diabetes. , 2004, Molecular genetics and metabolism.

[32]  D. Eizirik,et al.  Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. , 2004, Endocrinology.

[33]  P. Butler,et al.  Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. , 2003, Diabetes.

[34]  K. Rajewsky,et al.  Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 , 2003, Nature Immunology.

[35]  D. Newmeyer,et al.  Mitochondria Releasing Power for Life and Unleashing the Machineries of Death , 2003, Cell.

[36]  Robert A. Rizza,et al.  β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes , 2003, Diabetes.

[37]  Robert A Rizza,et al.  Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. , 2003, Diabetes.

[38]  Michael Karin,et al.  A central role for JNK in obesity and insulin resistance , 2002, Nature.

[39]  Kiyoshi Inoue,et al.  ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. , 2002, Genes & development.

[40]  T. Okura,et al.  Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. , 2002, Biochemical and biophysical research communications.

[41]  J. Corbett,et al.  Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production , 2002 .

[42]  J. Corbett,et al.  Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. , 2002, Diabetes.

[43]  E. Araki,et al.  Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. , 2002, Apoptosis : an international journal on programmed cell death.

[44]  T. Mandrup-Poulsen,et al.  A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis , 2001, Diabetologia.

[45]  Masataka Mori,et al.  Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[46]  M. Atkinson,et al.  Type 1 diabetes: new perspectives on disease pathogenesis and treatment , 2001, The Lancet.

[47]  Neal N. Iwakoshi,et al.  Plasma cell differentiation requires the transcription factor XBP-1 , 2001, Nature.

[48]  M. Tohyama,et al.  Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress* , 2001, The Journal of Biological Chemistry.

[49]  Yoshifumi Watanabe,et al.  WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. , 2001, Human molecular genetics.

[50]  D. Schorderet,et al.  Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. , 2001, Diabetes.

[51]  D. Schorderet,et al.  Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of β-Cell Death , 2001 .

[52]  G. Lathrop,et al.  EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome , 2000, Nature Genetics.

[53]  M. Rewers,et al.  Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[54]  F. Urano,et al.  Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.

[55]  Junying Yuan,et al.  Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β , 2000, Nature.

[56]  A. Strasser,et al.  Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction. , 2000, International immunology.

[57]  G. Korbutt,et al.  Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction. , 1999, Diabetes.

[58]  P. Behn,et al.  A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) , 1998, Nature Genetics.

[59]  W. Suarez-Pinzon,et al.  Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. , 1998, Biochemical pharmacology.

[60]  Xiaozhong Wang,et al.  CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.

[61]  R. Zinkernagel,et al.  Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice , 1997, The Journal of experimental medicine.

[62]  C. Janeway,et al.  The Role of Fas in Autoimmune Diabetes , 1997, Cell.

[63]  W. Suarez-Pinzon,et al.  Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets. , 1996, Endocrinology.

[64]  K. Guyton,et al.  Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element. , 1996, The Biochemical journal.

[65]  M. Mcdaniel,et al.  Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. , 1994, The Biochemical journal.

[66]  E. Leiter,et al.  Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors , 1993, Diabetes.

[67]  D. Ron,et al.  CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. , 1992, Genes & development.

[68]  L. Wicker,et al.  Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice , 1986, Diabetes.

[69]  G. Eisenbarth Type I diabetes mellitus. A chronic autoimmune disease. , 1986 .

[70]  M. Löhr,et al.  Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. , 1985, Survey and synthesis of pathology research.